Lee Lab

🔬🧠 Our paper on smart microscopy & the issue of interoperability! biorxiv.org/content/10.110… LONG THREAD WARNING: Smart microscopy uses real-time image analysis to automatically guide the acquisition or perturbation (closed feedback-control loop). Many applications exist:

Why would anyone want to be a scientist? Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/13…

Pleased to share that a SLM can achieve multiple FRAP to HILO to TIRF. biorxiv.org/content/10.110… (to appear in Opt Exp opg.optica.org/oe/home.cfm). Great work done by @aviupadhya and Daniel linkedin.com/in/daniel-lim-… from the team.

Now published in @NatureComms! 🥳 👉 rdcu.be/eATn3 We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces and combined soft matter physics with experimental biology. 1/n

Blebbisomes! They do more than in this paper! More coming soon! #CellBiology nature.com/articles/s4155…

Fast, flexible, learning-free organoid quantification and tracking with OrganoSeg2 Cameron J. Wells, Najwa Labban, Shayna L. Showalter, Roza K. Przanowska, Kevin Janes doi.org/10.1101/2025.0…

Hawkins, Fernandez-Gonzalez et al. @UofT introduce ReSCU-Nets, recurrent neural networks for integrated segmentation and tracking of three-dimensional #microscopy images. hubs.la/Q03C7v1_0

📢 PRFluids Editors' suggestion: When coughing or sneezing, mucus forms bag-like structures that break into droplets. Experiments and simulations show that viscoelasticity makes these bags larger and thinner, which reduces the droplet size upon rupture. go.aps.org/3UmUJEs

3D fibrin gel-generated mechanical signalling allows robust expansion of stem-like CAR T cells within 4-5 days. Mechanical signaling via β2 integrin decouples T cell proliferation and differentiation for generating stem cell-like CAR T cells: Immunity cell.com/immunity/fullt…

@focalplane_jcs are looking for ECRs to speak in their mini-symposium, run together with the popular membrane trafficking webinar series organised by @Fran_Bottanelli @felixmendu & @ishier_raote. focalplane.biologists.com/2025/07/14/foc… Apply by 24 August

ROCK inhibitors #Fasudil #Belumosudil suppresses 🐭#SubretinalFibrosis with laser-induced choroidal neovascularization Cool #ImagingMassCytometry 25 antibodies with metal isotopes for single-cell ocular pathology🤠 @researchsquare 2025 researchsquare.com/article/rs-492…

🎉 We are excited to announce the 'Consortium for the Equations of Life and Living-Systems' (CELL), an open collective dedicated to building the rigorous mathematical core that biology needs. The principles are based on #OpenScience. We will publish the blueprint soon. Please follow here for further announcements and logistics: x.com/CellBioSF For every generation, there is a frontier. In the last century, physics gave us the equations for the cosmos. In this century, we will write the equations for life. This is the great scientific challenge of our time. While biological data grows exponentially, our ability to predict the behavior of living systems lags behind. The gap isn't a lack of data; it's a lack of unifying theory. We have published a teaser that introduces the concept of “Mathematical Organisms,” outlines the eight universal operator families, and shows how a rigorous algebra can turn biology’s raw data into predictive equations. We are looking for community leaders, leading experts in mathematical biology, biophysics, computational biology and life sciences to help grow the consortium. If this mission resonates with you, I invite you to read the full post and reach out. Memberships are free for now. We shall meet soon in San Francisco. Read Article: medium.com/mathematical-o… #MathematicalBiology #Biophysics #ComputationalBiology #AI #Innovation

For those interested in the role of cancer-associated fibroblasts in the tumor microenvironment, please check out our review focused on recent discoveries related to CAF biology in the context of immunotherapy, metabolism, and extracellular vesicles: authors.elsevier.com/c/1lR1I_LjpbTT…

Following on from their successful meeting in 2023, @J_Cell_Sci are delighted to announce a second iteration of the Imaging Cell Dynamics meeting to be held in 2026. Find out more and sign up for registration and abstract updates at biologists.com/meetings/jcsim… #JCSimaging

Flow visualization often relies on synthetic particles like glass microbeads, but biodegradable starch particles from plants offer a safer, sustainable, and cost-effective alternative that has been successfully tested with foils, jellyfish, & brine shrimp! go.aps.org/45e0RUA

Organisms often swim through inhomogeneous environments, such as viscoelastic fluids, where gradients in viscosity and elasticity may arise. A new Letter shows that spatial variations in fluid relaxation time induce durotactic behavior in active particles. go.aps.org/4lPBGyI

A simple flow of gas over water may have helped kickstart life on early Earth. Research shows how evaporation and fluid flow in a narrow channel can drive isothermal DNA replication, offering a plausible, low-temp setting for early molecular evolution. elifesciences.org/articles/10015…

4.13/ However, in practice most modes would get very little use if one could not switch effortlessly between them. Indeed, the speed of mode switching in MOSAIC enables correlative imaging of the same specimen across multiple modes during a single dynamic times series, something few other microscopes can boast:

Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out. biorxiv.org/content/10.110… @Eric_Betzig @legant_lab

One month left to apply for a funded early-career researcher place at our Workshop 'Macro to Micro: Quantitative Plant Imaging Across Scales' organised by Mark Fricker, Alexander Johnson, Joseph McKenna and Markéta Šámalová biologists.com/workshops/febr… #BiologistsWorkshops