bruce.moran

@myESMO Recommendations for clinical reporting of genomics - now published in @Annals_Oncology. We're aiming to advance rational, evidence-based use of genomics in patient care and harmonize biomarker interpretation in cancer treatment annalsofoncology.org/article/S0923-…

Here’s the newest and final version: 𝘀𝗻𝗣𝗔𝗧𝗛𝗢-𝘀𝗲𝗾: unlocking the pathology archives A method/protocol that works very well, has been widely accepted and embraced by scientists globally, yet not as much by peer-reviewed journals. biorxiv.org/content/10.110…

@yokofakun Vespula vulgaris, common wasp most likely

@AedinCulhane Agree 100%, would be interested to see data to support 500 vs. 50 gene panels in terms of cost + scaling. Also entirely agree that making clinically generated data accessible to research community is necessary.

All cancer patients should have access to genomics guided therapy #WorldCancerDay But a larger 500+ gene panel is recommended over multiple different 12-gene tests. - speed & economy of scale in the lab. - basket clinical trials for drug repurposing (eg DRUP) - research data

Today, we launch the National Strategy for Accelerating Genetic and Genomic Medicine in Ireland which outlines the approach for developing a patient and family centred #genetic and #genomic service. bit.ly/3FPyYXg

@nilshomer You can't know everything. Draw mental boundaries based on your interests. Use new projects to redraw boundaries by learning something you think will be useful if time permits (IMO it always should).

Experienced Bioinformaticians: Comment below the one thing you'd like to tell junior Bioinformaticians. New Bioinformaticians: Read below for an awesome list of career tips.

📢 📢 📢 📢 📢 📢 📢 📢 1/ Psyched to share our latest in @Cancer_Cell. “Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors”. cell.com/cancer-cell/fu… Accompanying highlight:cell.com/cancer-cell/fu…

@tangming2005 'while read'

What UNIX command tricks you wish to know when you started? Me: less -S to unwrap the lines #unixcommands

Out now in @genomeresearch - our comprehensive analysis of the effects of aneuploidy on protein expression. Changes in gene dosage trigger complex compensatory mechanisms that are conserved from yeast to cancer! Great work led by @DrKlaske. genome.cshlp.org/content/32/7/1…

So disappointing, yet so very very unexpected. I'm sure there were excellent candidates, why did they not take the job..... medicalindependent.ie/in-the-news/la…

$ git log --oneline 47972a3 feature: some awesome complex idea a12a560 first attempt failed, try again 72dbea7 fixed silly typo 4e048f6 fixed 3f5c3b2 fix 59f3d56 fix dd3da66 f f1a8ca6 f 8af6c93 ... 3c72dae fuck

recount3, from @chrisnwilks. @KasperDHansen, @BenLangmead & co, is a resource of 750,000 mouse and human RNA-seq datasets uniformly processed with the same pipeline. It allows rapid queries across the whole dataset, eg cross-species or cross-study genomebiology.biomedcentral.com/articles/10.11…

🆕@CD_AACR Functional STK11 mutations is associated with resistance to ICIs in #lungcancer & is reversed by STAT3 knockdown 🌟 #LCSM cancerdiscovery.aacrjournals.org/content/11/11/…

Announcing the @ClinGenResource Criteria Specification Registry cspec.genome.network, a database for the management of the Criteria Specifications of @TheACMG evidence codes for variant classification from ClinGen Variant Curation Expert Panels #variantclassification

🎉200+ authors came together to deliver the latest issue of @cellgenomics, featuring GA4GH-enabled interop. These papers represent years of tireless effort from a truly global community; we are deeply grateful to each of you. cell.com/cell-genomics/…

Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA sciencedirect.com/science/articl…

Our work developing Repair-seq, a platform for studying #DNArepair processes, and its application to double-strand breaks is out today @CellCellPress. Alongside, we release seq.repair, a portal for exploring many, many DNA repair phenotypes! cell.com/cell/fulltext/…

1/ What are the challenges ahead for multi-modal data integration to improve precision oncology? In this @NatureRevCancer perspective we outline how we might leverage diagnostic cancer data as a substrate for next generation integrative biomarkers. nature.com/articles/s4156…

Next-generation immunotherapy: what's next after anti-PD-1/PD-L1 and anti-CTLA4, how to increase the chance of success of novel immuno-oncology strategies in the clinic, and moving towards personalized immuno-medicine. A great review by @merghout and team! nature.com/articles/s4157…

Clinical challenges in Genomic Medicine for Cancer Care | 15 Oct Register now for this free webinar⬇️ courses.rcpi.ie/product?catalo… #GCchat #genetictesting #genetics #genomics