Antonino Cassotta

Researchers in @scisignal discovered a signaling mechanism that prevents T helper 17 cells from adopting pathogenic states linked to autoimmunity, potentially informing future efforts to treat autoimmune diseases such as multiple sclerosis. Learn more on #WorldMSDay: scim.ag/4uxwR19

Join our lab at Karolinska Institutet in beautiful Stockholm 🇸🇪! We are recruiting an enthusiastic postdoc to dissect tumor-reactive T cells in cancer patients and help advance immunotherapies, collaborating closely with clinical researchers. Apply here: ki.varbi.com/en/what:job/jo…

Bianchi et al find that the FCRL3 receptor is expressed upon repetitive activation of human memory T lymphocytes & limits their responses via inhibitory pathways. This study identifies FCRL3 as a regulator of highly differentiated memory T cells in humans hubs.la/Q03NJZc10

This year’s medicine laureate Shimon Sakaguchi discovered a new class of T cells. Sakaguchi was swimming against the tide in 1995, when he made a key discovery. At the time, many researchers were convinced that immune tolerance only developed due to potentially harmful immune cells being eliminated in the thymus, through a process called central tolerance. Sakaguchi showed that the immune system is more complex and discovered a previously unknown class of immune cells, which protect the body from autoimmune diseases. #NobelPrize

Researchers have discovered a signaling mechanism that prevents T helper 17 cells from adopting pathogenic states linked to #autoimmunity, potentially informing future efforts to treat autoimmune diseases such as multiple sclerosis. @BRFAA_IIBEAA scim.ag/3W4vCqB

Researchers have discovered a signaling mechanism that prevents T helper 17 cells from adopting pathogenic states linked to #autoimmunity, potentially informing future efforts to treat autoimmune diseases such as multiple sclerosis. @SciSignal scim.ag/3VzX9jA

Epigenetic reprogramming that promotes oxidative metabolism suppresses TH17 cell pathogenicity @scisignal 🇬🇷🇮🇪🇦🇹🇫🇷🇨🇭 science.org/doi/10.1126/sc…

@OdedRechavi Very cool! Is it possible to run it locally to maintain confidentiality over partially formed ideas?

Can AI save the day? check out our new tool for pre-submission review (find your paper's weak spots in time!) it's called q.e.d. (qedscience.com)

Polyfunctional, cytotoxic, TCR-biased CD4 T cells, targeting NY-ESO-1, offer great promise for adoptive cell transfer in patients @ScienceAdvances science.org/doi/10.1126/sc…

The AI Revolution Is Underhyped | Eric Schmidt | TED youtu.be/id4YRO7G0wE?si… via @YouTube

🚨Today in @CellCellPress, we show that RNA splicing factor mutations in myeloid cancers generate splicing-derived public neoantigens targetable by #TCR tx. Amazing collaboration co-led by @AbdelWahablab, @bradleybio, and @KlebanoffLab. #Tcellpower cell.com/cell/fulltext/…

Learning the language of T cell receptors through large-scale screening: Cancer Cell cell.com/cancer-cell/fu…

Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation @NatImmunol nature.com/articles/s4159…

Our latest review in JCI is out - T cells in cardiac health and disease jci.org/articles/view/… @CNIC_CARDIO @CIBER_CV

Elucidating the role of autoreactive T cells and B cells in autoimmune hepatitis @jclinicalinvest jci.org/articles/view/… jci.org/articles/view/…

Excited to share our paper in @NatImmunol Congrats to Xin (Co-first) and all the other authors (@VMallajosyula, @KaranRKathuria and more). Special thanks to Prof Mark Davis for all his mentorship and guidance! @UCPH_health @StanfordMed @lundbeckfonden nature.com/articles/s4159…

Our new #organoid #organchip #coculture review. Congrats @_KamilMoskal, @Yeseul700lee, Luisa Siegert, Nimisha Khurana from @EMIL_DKFZ @DKFZ! Cool experience connecting the dots between in organotypic models and microbiome with @HansClevers and @EranElinav!

A cure for HIV? TCR agents seek to wipe out viral reservoirs nature.com/articles/s4158…

Top 4 misconceptions about science 1. It fills knowledge-gaps (discoveries are unknown unknowns) 2. It proceeds along a straightforward path (discoveries are not predictable) 3. It looks for answers (new questions are crucial) 4. It is only rational (requires night science leaps)

Congrats for this beautiful work!