dalan

@PatrickHeizer What’s a reasonable explanation of how they knew what parts of the dna to fix and what the pairs needed to be fixed _to_?

Sorry to be the downer because this is an impressive story in some senses. But it is ~trivially easy to make a single mRNA vaccine. It's not hard. I cure mice of various cancers with various therapeutics all the time. I've made mice lose more weight in a month than tirzepatide does in a year. What is hard and expensive is proving its BOTH safe AND effective **in a randomized and controlled study in humans** while ALSO manufacturing it at clinical scale and grade. I am happy for this man and his dog. It is impressive. But y'all are overhyping it.

Photographer @mostafabassim1 photographed this boy walking home alone with a snack being "randomly" approached by DHS. "After he was unable to produce documentation proving his citizenship, agents informed him that he was under arrest." He said, "Can I just go home?" Answer: No.

1/ Today @stripepress publishes one of my favorite books to date: Maintenance: Of Everything, Part One by @stewartbrand, about the unglamorous yet civilizationally important work of maintenance and repair.  press.stripe.com/maintenance-pa…

I'm very excited that we now have results from an almost two-year randomized controlled trial that we ran across thousands of businesses on Stripe: those that accepted a loan from @Stripe Capital grew annual revenue around 27% faster. (Two years isn't that long in the scheme of things, but it is when you're waiting for the results of an experiment you're interested in.) We had two kinds of controls: businesses to whom we offered loans but didn't accept them, and a holdout group of businesses to whom we randomly did not offer loans but which were otherwise identical to those to which we did. As such, we feel confident in the causal nature of this conclusion. While this might not sound like news ("capital increases growth"), I think the finding is a good reminder that many businesses are still quite capital-starved (this effect is on top of all of the other sources of capital that businesses have access to), and it is consistent with what we hear directly from businesses in surveys. Beyond Stripe, inefficient capital allocation at economy-wide scale is likely a major bottleneck to growth around the world. We have an ambitious roadmap planned and we're very much looking forward to expanding worldwide access to growth capital.

👀 bfcm.stripe.com

🔥 Today we’re excited to announce new funding for `grep` (at a $1.3B valuation) to continue building the foundation of agent observability and text search infrastructure. grep began as a humble UNIX utility in 1973. Since then, it’s evolved—through recursive innovation and the rise of ripgrep—into a core platform for developers, sysadmins, and agents. Our tools now power engineering and AI teams across @OpenAI, @Anthropic, @Meta, @Cloudflare, @Replit, @NASA, and thousands more. Over the decades we’ve iterated from grep to `egrep` to `ripgrep`. Our goal has always been to figure out what intelligent agents of the future need to see, filter, and extract—and then build the tools that make that possible. While our journey is still just beginning, we also want to take a moment to reflect on how the space (and our role in it) has evolved. You can read our reflections and details on this funding milestone here: gnu.org/software/grep/… We also share more about the funding that will power our future there. Thank you to @IVP, @Benchmark, @Sequoia, @CapitalG, and the open-source community for their belief in the enduring power of regex. What excites us most today is what’s next: grep 5.0 with AI-assisted pattern synthesis ripgrep Cloud, bringing distributed search to agent clusters pgrepGPT, an agent-native process discovery layer And new no-code integrations for autonomous observability pipelines We’re in the midst of a transformation in computation itself. grep and ripgrep will remain at the core—helping humans and agents alike find what matters, faster.

The absolute king

TIL you can just run `networkquality` in your terminal on MacOS

Until ~2015, GitHub Pages hosted over 2 million websites on 2 servers with a multi-million-line nginx.conf, edited and reloaded per deploy. This worked incredibly well, with github.io ranking as the 140th most visited domain on the web at the time.

Out now: press.stripe.com/origins-of-eff… 200 years on from the Industrial Revolution, we still struggle to understand what makes a production process more efficient. The Origins of Efficiency fills in that gap. Examining industries from steel to semiconductors to auto manufacturing, @_brianpotter reveals how production processes work and how they become faster, cheaper, and more reliable over time.

Accidentally said "I think" instead of "I reckon" and they kicked me out of Australia.

This payment is only going over 2048-bit encryption? Ah nvm then.

The tiny Caribbean island of Anguilla now derives almost half of its state budget from the sale of .ai domain names.

@awesomekling @ladybirdbrowser Wow! Huge spike! What caused that?

Hooray! @ladybirdbrowser has passed the 90% threshold on web-platform-tests! 📈🎉 This is the arbitrary limit Apple says we must reach to be considered an eligible alternative browser engine on iOS. (+ other requirements) So proud of the team for getting us this far 💜

@obsdmd Available in iOS?

Introducing Bases, a new core plugin that lets you turn any set of notes into a powerful database. Now available to everyone with Obsidian 1.9!

I don't know who is the product manager at @stripe that was in charge of making the Organization system, but they cooked!! You can create an account and copy all the settings of a previous account in 2 clicks instead of manually adding everything, so good!

@OpenAI desktop should allow me to do the secret incantation to connect to locally running connectors if I really really really am sure I want to do that. Surely in naught-point-two seconds there's going to be a homelab service that will manage and proxy to everything.

I wrote my first MCP server ~completely with Codex. The only thing I could think of that didn't have an MCP built for it already was the @BOM_au.