Andres M Bran

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Andres M Bran

Andres M Bran

@drecmb

CTO b12 Labs | YC S25 | https://t.co/u3rprn2qhQ Prev PhD @EPFL | @mpiMathSci. Building Crows for Chemists, Automating Synthesis 🐦‍⬛🚀

San Francisco, CA Katılım Nisan 2016
616 Takip Edilen748 Takipçiler
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Andres M Bran
Andres M Bran@drecmb·
New version of ChemCrow out 🔥🔥 arxiv.org/abs/2304.05376 The LLM-powered chemistry assistant got major updates 💪 What's new? Robots synthesizing stuff, human/crow collaboration, novel molecules, safety, new evaluations + open source release! 🤩 See more 👇 1/8 #compchem
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Andres M Bran
Andres M Bran@drecmb·
@michellearning It's not the main bottleneck - just as coding was never really the bottleneck. Yet coding agents are quite useful and enable to build many more things on the same components. Do agree there's much more to it than NL, but it does enable part of your last point
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Andres M Bran
Andres M Bran@drecmb·
@Dorialexander Fair enough - maybe less about the data than abt the physical deployment of intelligence and the loops created out of that
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Alexander Doria
Alexander Doria@Dorialexander·
@drecmb They will (not completely but enough to displace where the skills should go)
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Alexander Doria
Alexander Doria@Dorialexander·
That might surprise people following me for a while but I’d register the reverse prediction: data will matter less.
will depue@willdepue

A Stargate for Data Labs are on a trajectory towards >$100B/year of data spend by 2030. As we begin the trillion-dollar compute project, we need to think about the equivalent civilizational-scale effort for the other core ingredient: data. At the foundation of the scaling revolution is a simple empirical law: deep neural networks improve smoothly, near magically, as you scale two things in proportion — (1) the size of the model and (2) the amount of data you train on. And despite the scaling laws being brutally diminishing, we’ve successfully bitten the bullet of logarithmic scaling with exponentially larger clusters and datasets, and received incredible new capabilities in return. But this exponential scaling is bound to hit some limits. Oddly enough, compute has compounded fairly smoothly without limit, with trillions flowing into hypercluster buildout. Instead, we’re starting to hit the limits of an exponential demand for data. Gone are the days of being purely in the compute-limited regime, where we had effectively infinite internet data but never enough GPUs, we’re now entering a data-limited regime. Luckily, this limitation is coinciding with staggering improvements in AI capabilities. Incredibly, we seem to have a real line of sight towards automating a majority of knowledge work with the methods we have today. RL + pretraining, and the data for each, will be generally sufficient to achieve most economically valuable tasks, given some minimal algorithmic progress and continued compute scaling. In a data-limited world, economic progress & scientific acceleration will be directly bottlenecked by our coverage in each domain. We need to see data collection as imperative, deserving the same civilizational ambition we’ve given compute. The internet as a one-time subsidy It’s underrated how much all progress in AI owes everything to the blessing of the internet, this one-time civilizational subsidy to deep learning, decades of unintentional accumulation of a perfect dataset: every book, blog post, image, video, paper, discussion, etc. all digitized and freely available. Without the internet, we’d likely see comparably minimal progress in AI today, and in fact, if you notice where systems currently underperform, it’s almost always a domain where web coverage is limited and data is private, expensive, non-digitized, or non-existent. But we’re running out of it. There are only about 300 trillion tokens of useful public human text, and the internet doesn’t produce nearly enough new high-quality data to match what scaling demands — we’re soon to hit the limits of public data for pretraining. And though the advent of RL bought us reprieve — chain-of-thought RL needed a new form of untapped data, gradable math & coding tasks, also available online — we’re quickly running dry of hard tasks for RL as well. Why do we need so much data anyways? Humans learn comparably in far less time, needing just one textbook where language models might need the equivalent of hundreds to learn a new topic. It’s possible we discover methods that are massively more data efficient — synthetic data, data efficient architectures, other exotic algorithms — but fundamental progress is slow and highly unpredictable, and the recipe we have just works today. And, while I’m wary of getting too deep here, even arbitrary data efficiency can’t replace data that just doesn’t exist in the first place. There’s a massive amount of missing information on the web: the dark matter of the internet — tacit knowledge, undocumented processes, etc. — most of which was never published and lives only inside organizations, the physical world, or just in people’s heads. I’ll leave it here and say, for reasons far longer than I can fit in this post [1], it’s best to operate on the assumption that our insatiable desire for data will continue as it has for the last decade. There will be >$100B/year in data spend by 2030 We’re not screwed yet, of course. Only a fraction of useful data in the world is on the public internet, the rest is stored inside private datasets, corporations, personal archives, universities, governments, and otherwise. Labs can and will continue to license these private datasets, or create them from scratch, like Anthropic’s book scanning project. And we’ll increasingly task human experts to manufacture new high-quality data, with a large fraction of hard RL training tasks already being sourced this way. But collecting this data, unlike before, will be expensive. As the free internet dries up and demand for data rises, we should see labs investing equally in data as compute, likely spending a significant fraction of their compute budgets on data. As we see trillions spent on compute, we should also expect hundreds of billions spent on data (human data & collection budgets), given their equivalent importance. And, notably, data spend is already tracking this way: total data spend across vendors, not counting internal lab efforts, is already roughly $7 billion per year. It’s quite reasonable we’ll see >10x by 2030. Data is the moat Data becoming increasingly private will also majorly shift the competitive landscape. While compute is a commodity — everyone buys the same chips and builds the same clusters — data really isn’t. The big reason why frontier models have felt eerily similar to one another, until now, is they were trained on substantially the same internet (pretraining data variability across labs seems pretty low). As labs diverge onto more exclusive, manually collected corpora, I think models will begin to increasingly diverge. OpenAI pulling ahead in mathematics and Anthropic in cybersecurity isn’t an accident. I really think laser-focused collection of high-quality midtraining tokens, custom RL tasks, environments, with dedicated research effort, has driven much of the visible progress in the last year. James Betker has an excellent blog about “the ‘it’ in a model is the dataset”: model architecture and compute buy you efficiency and order-of-magnitude performance, but ultimately, models, of any architecture, are such incredible approximators of their dataset that the core meat of a model boils down to just that, nothing else. Data is a major moat. AGI long, ASI short As I’ve tweeted before, I’m confident that, despite the narrative, the data labeling industry will continue to fuel great businesses and be an excellent AGI long, ASI short. The argument is just: By the time the AGI labs no longer need data, it’s probably over for everything else too [2]. In this frame, the last companies left should be the data companies, as the last speck of economically relevant data is sucked in. And these companies are already among some of the fastest-growing companies in history: Mercor, founded three years ago, is rumored to be doing $2 billion in revenue with something like a few million expert labelers under contract. While these businesses are very non-stationary, what type of data is needed shifts constantly, I don’t think that diminishes their value. The long-tail of the economy is long, and the value isn’t diminishing as you extend farther into more obscure information: as models get more capable, the value of the marginal dataset goes up, not down. Automating a full job means covering its full distribution of tasks, tools, edge-cases, and long-horizon loops. There’s some O-ring logic to it: a dataset that buys a 1% bump can justify a previously unjustifiable collection cost when it’s the difference between a system that does 99% of a job and one that does all of it [3]. The competitive dynamics of the data industry are still evolving but as demand for data is increasingly niche, ultra high-quality, expert-generated, I think we’ll see real consolidation. Again, contra-narrative, we’ll probably see true competitive differentiation built on brand, quality control of data (which, from personal experience, can vary massively), as well as in network effects from the talent networks themselves over time. We’ve already seen rapidly shifting data type demand work in favor of incumbents, benefiting those with early knowledge of where the market is headed. The binding constraint It’s truly remarkable that we seem to have the recipe — pretraining + RL — to absorb most economically valuable work, despite being far from a lot of what we expected from “AGI”. The same way chess engines revealed we never needed general intelligence to solve chess, as we originally thought, we’ll soon realize that software, mathematics, and the vast majority of the economy (including physical, just running ~3 years behind!) are the same. If recursive self-improvement or some other algorithmic breakthrough arrives, that’s wonderful, but we really don’t have to wait for it. The binding constraint between here and an automated economy isn’t that, it’s data coverage: every app, workflow, edge case, process, etc. sitting in private stores or someone’s head. Ultimately, while we make tremendous strides in more efficient model architectures, and clusters like Stargate equip us with zettaflop-scale compute, we really aren’t making rapid progress collecting the data we lack. We’ll soon live in a world where we have the methods & compute to accelerate scientific progress or economic growth, but not the data. And we’re already there today: frontier models would surely be as good at accounting/many medical tasks/legal advice as they are at software engineering if we only had the same pretraining & RL coverage as we did for code. I really want to drill this in: The speed at which we automate the economy is going to be directly rate-limited by our ability to collect data about it. Worth noting that under this assumption, with data as defensible and directly proportional to economic & scientific progress, data should also be considered a national strategic asset like compute. Imagine what we’d do in a world where we had a Manhattan Project-effort for AI and needed to mobilize data collection as a limiting factor. We should be concerned about China, with greater state capacity and authoritarian economic control, being capable of mobilizing data collection at national scale, potentially compounding their economy and scientific output faster than us down the line. A Stargate for data I’m leaving my complete ideas for a future post, as this one is already far too long, so I’d really like to pose the question here. Stargate exists because we organized trillions of dollars, international strategy, gigawatts around compute as a fundamental ingredient. What would equivalent ambition look like for data? Obviously, scaling data collection, a heterogeneous mass of information across the economy, isn’t going to be as clear as scaling compute, as a homogenous infrastructural effort. A core division will be first, coverage — all uncaptured knowledge sitting across the economy/science/physical world and all that simply isn’t recorded — and, secondly, sheer volume in the domains we already train on: more hard math tasks, more high-quality web text, way more coding data, more legal drafts, etc. I have a post coming soon which breaks down my proposals. There’s a lot of room for creativity. Quickly, we’ll probably want to start with a deep census of what we have and what we’re missing, predict what the 2030 model will still be bad at and work backward to what we should be collecting today. You can probably license a large amount, leveraging high lab valuations to buy datasets or companies altogether. There’s an adversarial nature to a lot of this collection with firms, so there’s lots of engineering to do this correctly. We should go convince important companies to turn off deletion policies, even if we’re not buying from them yet. Data flywheels in consumer products will be massive. Confidential training, government legislation for grant-funded research, running companies at a loss for their data, etc. We’re headed towards hundreds of billions in expenditure, national prioritization, and major data limitation on the horizon. We have a great opportunity to think creatively about what a megaproject for data would look like: How do we, deliberately this time, construct the next internet’s worth of data? Footnotes: [1]: I’ll probably soon publish my much longer post explaining my position on data efficiency and why the value of this data is still pretty high in most worlds regardless of new algorithms. [2]: The “AGI freeroll” bet: heads you win, tails ASI flips the world upside down anyways. [3]: We already see a glint of validation of this point, given the data market is strongly tilting towards ultra-high-quality agentic data, rather than unskilled labeling — niche expert workflows, live environments, and evaluations requiring increasingly obscure talent & knowledge — yet shows increasing, not decreasing, revenues.

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Mgoes (bio/acc 🤖💉)
Mgoes (bio/acc 🤖💉)@m_goes_distance·
hot take: 90% of biotech startups aren't fundable not because the science doesn't work, because they're building a product we're looking for founders building the infrastructure that makes thousands of products possible - autonomous wet labs - peptide quality infrastructure - AI-native biology tooling - biological age diagnostics - clinical trial infrastructure - non-invasive BCIs - and/or adjacent biotech the products get funded easily. the infrastructure underneath them almost never does. that's the gap we're closing let's talk, what are you building?
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owl
owl@owl_posting·
Life update: after an incredible year at Noetik, I’ve joined the OpenAI Foundation (@FoundationOAI) to help create its "Public Data for Health" program. The OpenAI Foundation is a well-capitalized philanthropy, and a meaningful share of its funds will be committed to building and opening up the datasets necessary to massively accelerate biomedical research. Some of our grants will go toward efforts to relieve known data bottlenecks, but others will be more speculative, made on the premise that artificial intelligence is currently reshaping how scientific discovery happens, and that this reshaping will surface fundamentally new data bottlenecks of its own. We have a long to-do list ahead of us, and I’m ecstatic to be joining @JacobTref on this effort! On writing: I’ve spent the last few years covering the intersection of AI with many, many subfields of the life sciences at owlposting.com, and it will continue + remain independent. Many exciting essays and podcasts are planned! Lastly, I remain extremely optimistic on Noetik and am very thankful for my time there. Consider following @Ronalfa and @recursus to stay updated on their efforts!
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Andres M Bran retweetledi
Zlatko Jončev
Zlatko Jončev@ZJoncev·
If you want to get much much better performance in retrosynthsis and reaction optimization then just using LLMs, and actual execution of experiments talk to us we have been building and evaluating agents in this exact space for years. @b12Labs
Anthropic@AnthropicAI

New Anthropic Science Blog: Making Claude a chemist. To manipulate a molecule, chemists first need to understand its structure. Their main tool is NMR spectroscopy. We found Opus 4.7 matches—and on some tasks beats—dedicated NMR software. Read more: anthropic.com/research/makin…

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Andres M Bran
Andres M Bran@drecmb·
@AnthropicAI Such an exciting direction! Esp what's next: synth planning and mechnisms. We did just that recently cell.com/matter/fulltex… and claude (Sonnet 3.7) was the first model ever achieve good scores at these tasks! We're continuing to build evals just for this at @b12Labs 🔥
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Anthropic
Anthropic@AnthropicAI·
New Anthropic Science Blog: Making Claude a chemist. To manipulate a molecule, chemists first need to understand its structure. Their main tool is NMR spectroscopy. We found Opus 4.7 matches—and on some tasks beats—dedicated NMR software. Read more: anthropic.com/research/makin…
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Andres M Bran retweetledi
b12 Labs
b12 Labs@b12Labs·
In the quest toward automated synthesis, there's a massive gap between "this reaction looks good in paper" and actually running it. Turns out, someone has to select the conditions: temperature, ligands, additives... the right conditions turn an impossible reaction into real product! Today we’re announcing Palladium, our agentic solution for reaction condition and HTE plate design. Instead of starting with blind optimization, Palladium leverages precedent experiments and substrate-specific reasoning to design a strong first plate. Our beta users in academia and pharma have found conditions as high as 98%, and typically above 90% yield, on the first experiment, often with no follow-up experiments needed. This is how at b12 Labs (YC S25) we accelerate real chemistry. Read more b12-labs.com/blog/palladium… If you’re a chemist trying to accelerate difficult reactions, we’d love to talk.
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Zlatko Jončev
Zlatko Jončev@ZJoncev·
High-throughput platforms have found great application in process chemistry teams, where you need to debug reactions by exploring chemical space with a relatively standardized output to measure. But at the scale of 96-384-1536 wells at a time, even the best chemists struggle to keep all results and hypotheses in mind, and have mostly converged on factorial-based designs. Today, we are announcing Palladium, b12’s plate designer tool, which mimics the way chemists would think, hypothesize, test, analyze, and iterate on HTE conditions, and does so on scale. What I find amazing is that you can go from SMILES strings to complex hypothesis testing in just a few clicks. First results are very promising, stay tuned for experimental validation details soon.
b12 Labs@b12Labs

In the quest toward automated synthesis, there's a massive gap between "this reaction looks good in paper" and actually running it. Turns out, someone has to select the conditions: temperature, ligands, additives... the right conditions turn an impossible reaction into real product! Today we’re announcing Palladium, our agentic solution for reaction condition and HTE plate design. Instead of starting with blind optimization, Palladium leverages precedent experiments and substrate-specific reasoning to design a strong first plate. Our beta users in academia and pharma have found conditions as high as 98%, and typically above 90% yield, on the first experiment, often with no follow-up experiments needed. This is how at b12 Labs (YC S25) we accelerate real chemistry. Read more lnkd.in/ec6jd63E If you’re a chemist trying to accelerate difficult reactions, we’d love to talk.

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b12 Labs
b12 Labs@b12Labs·
The @b12Labs team is joining @FutureLabs_Live next week in Basel! Meet our founders @ZJoncev and @drecmb at Booth S9. At @b12Labs (YC S25) we believe the future of Synthetic Chemistry is Agentic, and we are building that future. If you're around, let's meet and discuss chemistry and AI: we'll be excited to share our latest breakthroughs in retrosynthesis, reaction optimization, and integration with robotic labs! We’d love to connect with partners and chemists who are ready to embrace the agentic future of the lab. Let’s talk about how we can optimize your reactions and automate your workflows. #FutureLabs #AgenticChemistry #AI4Science #Chemistry #Synthesis
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b12 Labs
b12 Labs@b12Labs·
hello world 👀 🤖⚗️
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Zlatko Jončev
Zlatko Jončev@ZJoncev·
Great demos at Launch Live @ycombinator - remote control of robots, reinventing ultra sound, new transformer architectures for non-human tasks, and saving agents from dead-ends. YC events always feel like Im sent several years to the future.
Zlatko Jončev tweet mediaZlatko Jončev tweet mediaZlatko Jončev tweet mediaZlatko Jončev tweet media
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Xuan-Vu Nguyen
Xuan-Vu Nguyen@XuanVuNguyen18·
You don’t like molecular dynamics? We get it. That’s why at this year’s LLM hackathon for Chemistry and Materials Science, we built not one, but ✨two✨ AI agents for molecular dynamics 👇
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Andres M Bran retweetledi
Porter
Porter@porterdotrun·
B-12 (YC S25) brings chemical super-intelligence into your lab, leveraging AI agents to plan and execute complex, multistep syntheses, turning months of R&D into minutes. Co-founders Andres Bran (@drecmb) and Zlatko Jončev (@ZJoncev) use Porter for production-ready infra without any DevOps overhead. Spend less time managing CI pipelines and more time innovating: porter.run/for-seed-stage…
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Y Combinator
Y Combinator@ycombinator·
Synthetic Society tests your product with AI-powered user simulations. Their agents mimic real users to catch bugs, bad UX, and edge cases. Ship faster, kill manual testing, and build with confidence. ycombinator.com/launches/O7g-s… Congrats on the launch, @aaronchewbani and @kavandoc!
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