Sarah Hodges

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Sarah Hodges

Sarah Hodges

@hodges

Managing Partner at @Pillar_VC 🚀 ISTJ 🐢

Boston Katılım Şubat 2009
1.6K Takip Edilen9.5K Takipçiler
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Tony Kulesa
Tony Kulesa@kulesatony·
Freedom to Build What Matters The first glimmers of AGI are here. Whatever you can dream of, you can build. The efforts of a single individual have never mattered more. A single person, an idea, and a late night in the lab might be what changes a field. And yet the outputs of such extraordinary power have mostly been disappointing. We are using the most important technology in history to create addictive short-form video, AI girlfriends, and better ad targeting. Now is the time to do the work that will define this era. We can cure disease, feed a continent, or make humanity multi-planetary. What you choose to work on now may be the most consequential decision of your career. We built the Encode: AI for Science Fellowship for people who feel that weight. One year of salary, plenty of compute, and direct access to frontier labs, data, and domain experts across biomaterials, atmospheric science, neuromodulation, robotics, and more. No equity, no strings attached — just the freedom to explore. We've partnered with ARIA and the UK's leading research universities to make it possible. Applications close March 28th.
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jamiegoldstein
jamiegoldstein@jamieagoldstein·
Our founding Pillar CEO Stan Lapidus made the Forbes Innovators 250. The modern Pap test. Cologuard. 37 patents. Countless lives saved. Well deserved, Stan. forbes.com/sites/alexknap…
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Sarah Hodges
Sarah Hodges@hodges·
What will you build when you have the freedom to build what matters? Incredible things are happening in Boston—in labs, warehouses, and basements. The weird and the serious are moving fast. The window is open. We're helping kick off the Massachusetts AI Coalition with a launch event on creativity, cognitive science, and solving hard problems. Speakers from Harvard, MIT, Tufts, Oscillator, Rowan Scientific, Glia AI, and WHOOP. Link to register 👇
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Sarah Hodges
Sarah Hodges@hodges·
Today, @day_ai_app went to general availability. We've been using it internally, and the results are wild: - Asked for candidates for a role → now in active discussions with an exceptional leader we never would have sourced - Asked for an investor Q&A → it captured our actual voice, not corporate boilerplate - Asked for domain experts → surfaced names buried in 6-month-old meeting notes Congrats @ChrisODonnell @michaelpici and team 🎉 This isn't AI as a productivity tool. It's AI as a thinking partner 👇
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Christopher ODonnell
Christopher ODonnell@markitecht·
Today we're announcing Day AI's $20M Series A led by @sequoia, and that we're now generally available. We've spent 18 months building what we believe is the Cursor of CRM. Here's what that means 🧵
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Tony Kulesa
Tony Kulesa@kulesatony·
Science is our calling. It's January 2026 and in some vague but very real sense, the glimmers of AGI are here. You can toss off a goal and an AI agent will happily chug away. We can do anything. But what is worthy of doing? We're not here for the AI romantic companions, the vibes reels, and the marketing outbound. If we can do anything, we're going to do science. Science is how we build the world we actually want. It's how we will solve the problems we'll be proud to tell our children we dedicated ourselves to. We want to hear from the people pushing AI to the limits in pursuit of science. The window is open. The weird and the serious are moving fast. Incredible things are happening in labs, warehouses, and basements. Over the next couple of weeks, we’ll be gathering in three cities—San Francisco, London, and Boston. We’ll have some visionary speakers joining us. Link below.
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Sarah Hodges
Sarah Hodges@hodges·
There’s been a lot of talk about whether Boston is still a great place to build (we're bullish) — but talk doesn’t build companies. We’re moving into 30k+ sq ft this fall. How should we use it to actually help founders? Ideas welcome.
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jamiegoldstein
jamiegoldstein@jamieagoldstein·
10 years ago, we started @pillar_vc with a simple belief: Treat founders the way we would want to be treated and good things will happen. A decade later, the data says it works. 🧵
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Tony Kulesa
Tony Kulesa@kulesatony·
Super excited to announce Edison. I worked with Sam, Andrew, and team from the beginning to help form FutureHouse. When it came time to spinout Edison, I both invested and jumped in to build alongside them. I couldn’t be prouder of the progress we have made. Join us!
Sam Rodriques@SGRodriques

Science is too slow. At Edison, we are integrating AI Scientists into the full stack of research, from basic discovery to clinical trials. We want cures for all diseases by mid-century. We have raised a $70M seed to get started. Join us. We need cracked software engineers who want to work on finding cures rather than selling ads and generating slop. If you’re reading this, you’re probably a candidate. We need brilliant AI researchers who want to figure out how AI will accelerate real-world science. We need scientists and researchers with deep expertise in biology, biotech, and pharma who want to figure out how to integrate AI deeply into scientific workflows, from ideation to experimentation, and how to measure success or failure. We need extraordinarily talented generalist operators across BD, sales, product management, and partnerships who can focus on getting our tools into the hands of pharmaceutical companies. If any of these roles sound like you, get in touch. We are also expanding access to our platform. Our goal is to accelerate science writ large. To that end, we will continue to give academics and students 650 credits/mo indefinitely. I can’t promise we’ll keep this up forever, but we will try. Kosmos will still cost 200 credits, and the other agents (Analysis, Literature, etc.) will cost 1 or 2 credits. All paid users will have access to our regular agents, like our Analysis agent, Literature agent, and so on, for free via the UI. API access will still be paid, and users without a paid subscription will continue to get 10 credits per month for those agents. Our $200/mo subscription for 650 credits/mo is staying in place for now, but might be phased out at our next major product update. Along the lines of accelerating science, we’re also doing a major release of PaperQA today, our flagship open source literature agent, as part of our commitment to open science. In the short run, expect major improvements to Kosmos, including the ability to automatically access data, the ability to steer its exploration, and the ability to converse directly with its world model. In the long run, expect exponentially increasing rates of scientific discoveries, in biology and elsewhere. Our round is led by Triatomic Capital, Spark Capital, and a major US institutional biotech investor. We are also joined in this round by existing investors Pillar VC and Susa Ventures, two exceptional early-stage funds who backed us at founding, along with Striker Venture Partners, Hawktail VC, Olive VC, and a host of exceptional angels that includes famous AI researchers, the CEOs of multiple frontier AI labs, and leadership of major biotech and pharma companies.

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Sarah Hodges retweetledi
Sam Rodriques
Sam Rodriques@SGRodriques·
Today, we’re pushing a major update to Edison Analysis, our data analysis agent, which is tuned for scientific research and SOTA across data analysis benchmarks. In contrast to Kosmos, which runs for 6-12 hours and produces tens of thousands of lines of code, Edison Analysis runs for seconds to minutes and is best for specific, well-defined computational tasks. It is available both on our platform under the Analysis tab, and via API, and costs only one credit per run, so it is available to users on both free and paid tiers. Edison Analysis is a modified version of the data analysis agent Kosmos uses in its trajectories. Try it out! One of the most important improvements over our previous data analysis agents has been the addition of a specialized data retrieval tool. Edison Analysis can either use this tool to access data, or can pull data down directly via API. To evaluate this tool, we ranked the most commonly used public data repositories across recent papers from BioRxiv, and created a new benchmark that measures the ability of a language agent system to retrieve raw data from those sources. Edison Analysis gets 71% on this benchmark, and we’ll be working to increase this over time. You can read more about our benchmarks in the our blog post, link below. Some features worth highlighting: 1. Edison Analysis produces a report on the analysis it runs, along with a Jupyter notebook that you can download to reproduce the analysis yourself. Every figure it produces is linked back to the specific lines of code used to produce the figure, to make it easy to reproduce. 2. It works well with both Python and R. 3. One of the best uses for Edison Analysis is to use it to retrieve datasets that you can then analyze with Kosmos. We have a bunch of major improvements to Edison Analysis coming in the next few months that we’re excited to share. In the meantime, congratulations to the team, especially @ludomitch, @jonmlaurent, @cvi94 , @alexjandonian, and many more.
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Sam Rodriques
Sam Rodriques@SGRodriques·
@sama Thanks!! Anyone who is interested can try Kosmos for themselves here: platform.edisonscientific.com All possible in large part due to the amazing work you guys have been doing at OpenAI. Keep it up, and the next few years are going to be awesome.
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Sam Rodriques
Sam Rodriques@SGRodriques·
Today, we’re announcing Kosmos, our newest AI Scientist, available to use now. Users estimate Kosmos does 6 months of work in a single day. One run can read 1,500 papers and write 42,000 lines of code. At least 79% of its findings are reproducible. Kosmos has made 7 discoveries so far, which we are releasing today, in areas ranging from neuroscience to material science and clinical genetics, in collaboration with our academic beta testers. Three of these discoveries reproduced unpublished findings; four are net new, validated contributions to the scientific literature. AI-accelerated science is here. Our core innovation in Kosmos is the use of a structured, continuously-updated world model. As described in our technical report, Kosmos’ world model allows it to process orders of magnitude more information than could fit into the context of even the longest-context language models, allowing it to synthesize more information and pursue coherent goals over longer time horizons than Robin or any of our other prior agents. In this respect, we believe Kosmos is the most compute-intensive language agent released so far in any field, and by far the most capable AI Scientist available today. The use of a persistent world model also enables single Kosmos trajectories to produce highly complex outputs that require multiple significant logical leaps. As with all of our systems, Kosmos is designed with transparency and verifiability in mind: every conclusion in a Kosmos report can be traced through our platform to the specific lines of code or the specific passages in the scientific literature that inspired it, ensuring that Kosmos’ findings are fully auditable at all times. We are also using this opportunity to announce the launch of Edison Scientific, a new commercial spinout of FutureHouse, which will be focused on commercializing our agents and applying them to automate scientific research in drug discovery and beyond. Edison will be taking over management of the FutureHouse platform, where you can access Kosmos alongside our Literature, Molecules, and Precedent agents (previously Crow, Phoenix, and Owl). Edison will continue to offer free tier usage for casual users and academics, while also offering higher rate limits and additional features for users who need them. You can read more about this spinout on our blog, below. A few important notes if you’re going to try Kosmos. Firstly, Kosmos is different from many other AI tools you might have played with, including our other agents. It is more similar to a Deep Research tool than it is to a chatbot: it takes some time to figure out how to prompt it effectively, and we have tried to include guidelines on this to help (see below). It costs $200/run right now (200 credits per run, and $1/credit), with some free tier usage for academics. This is heavily discounted; people who sign up for Founding Subscriptions now can lock in the $1/credit price indefinitely, but the price ultimately will probably be higher. Again, this is less chatbot and more research tool, something you run on high-value targets as needed. Some caveats are also warranted. Firstly, we find that 80% of Kosmos findings are reproducible, which also means 20% are not -- some things it says will be wrong. Also, Kosmos certainly does produce outputs that are the equivalent to several months of human labor, but it also often goes down rabbit holes or chases statistically significant yet scientifically irrelevant findings. We often run Kosmos multiple times on the same objective in order to sample the various research avenues it can take. There are still a bunch of rough edges on the UI and such, which we are working on. Finally, we are aware that the 6 month figure is much greater than estimates by other AI labs, like METR, about the length of tasks that AI Agents can currently perform. You can read discussion about this in our blog post. Huge congratulations to our team that put this together, led by @ludomitch and @michaelathinks: Angela Yiu, @benjamin0chang, @sidn137, Edwin Melville-Green, Albert Bou, @arvissulovari, Oz Wassie, @jonmlaurent. A particular shout out to @m_skarlinski and his team that rebuilt the platform for this launch, especially Andy Cai @notAndyCai, Richard Magness, Remo Storni, Tyler Nadolski @_tnadolski, Mayk Caldas @maykcaldas, Sam Cox @samcox822 and more. This work would not have been possible without significant contributions from academic collaborators @mathieubourdenx, @EricLandsness, @bdanubius, @physicistnevans, Tonio Buonassisi, @BGomes_1905, Shriya Reddy, @marthafoiani, and @RandallBateman3. We also want to thank our numerous supporters, especially @ericschmidt, who has been a tremendous ally. We will have more to say about our supporters soon!
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