Benjamin Chang

My first PhD paper is out now in @Nature! Very grateful to have worked with the FutureHouse team on this, and a big shoutout to my co-first author @agreeb66 😀

@exnx @MichaelPoli6 @Massastrello @athmsx @RadicalNumerics Congrats Eric, super excited for you all!

Together with my co-founders Michael @MichaelPoli6, Stefano @Massastrello and Armin @athmsx, I am excited to announce @RadicalNumerics is emerging from stealth with a $50M seed round to build general biological intelligence. We’re also sharing an early preview of our new model Omnii, the most powerful genome language model to date. Omnii preview link: radicalnumerics.ai/blog/radical-n… At Radical Numerics, our mission is to master the code of life, and to drive the frontier of biological AI for both design and defense. This is our dual mandate, which comes from something our own team helped make possible. Our founding team trained Evo and Evo 2, the largest biological AI models (40B params) trained on DNA sequences. Trillions of tokens across all of life, from microbes to mammals. It’s fully open source, and created the field now known as generative genomics. Last year, scientists used Evo to generate the world’s first complete genome from scratch using AI. Turns out it was a bacteriophage—a type of virus. It functioned in the real world, and in this case it was harmless. But for us, it was a clear turning point. It showed that AI is no longer just analyzing biology. It is on the cusp of generating functional lifeforms. Eventually, AI will have the power to design and control life itself. That should make all of us incredibly excited, and incredibly uneasy. (Anyone can design DNA with a new function, and have it synthesized and delivered, like something from Amazon Prime). The same technology that will help us cure cancer is the very technology that might create the next global pandemic, or worse, allow the creation of bioweapons that can wipe out populations. We believe these forces are inseparable. If you work on the frontier of biology, you have to build technology to safeguard it from its misuse. Existing biosecurity tools are sorely losing the arms race, relying on outdated “have I seen this exact thing before?” style algorithms. We founded Radical Numerics to turn the tide. And we can’t do that by training on textbooks and natural language. We must understand the language of biology from the raw physical data itself, to reason across every molecule and modality, from DNA to proteins. The next frontier for AI goes far beyond chatbots or video generators to models that can understand and engineer life. Today, we’re previewing Omnii, which is already far surpassing Evo 2, and will continue improving as we scale and add new modalities (training now). 1. For human health, Omnii can read and write whole genomes (more on writing later). It’s state of the art (SOTA) on detecting causal variants for disease, and can rank Alzheimer's mutations zero-shot. We’re partnering with a diagnostics company to use Omnii for early cancer detection (pancreatic and multi-cancer). 2. For defense, Omnii is SOTA at detecting AI-generated pathogens. We benchmarked existing detection tools, and they simply can’t detect the AI-generated ones (“deepfake viruses”). We’re partnering with a US national lab to pilot Omnii for detecting the next pandemic, both natural and AI-generated. We have a data center full of Blackwells in construction now to build the most powerful biological AI models ever. This mission takes a new kind of AI lab that can actually scale on physical, biological data: new alignment research (mid/post training), scaling long context, building out mech interp teams to dissect what these models learn, new architectures and systems designs, all from the ground up. Our team is made up of AI researchers and scientists from top labs and institutions (e.g. Stanford, MIT, Google DeepMind), but more importantly, we all share the belief that this is the most important challenge of our lifetime. If you feel similarly, we are hiring. We aim to bring the brightest minds in AI and science together to save lives. Thanks to our partners on this journey, led by Emergence Capital @emergencecap, with Obvious Ventures @obviousvc, Triatomic @TriatomicCap , and Patrick Collison @patrickc. Our advisors include Eric Horvitz @erichorvitz, CSO of Microsoft, Chris Re @HazyResearch of Stanford, George Church @geochurch of Harvard, and Andrew Weber @AndyWeberNCB, former Assistant Secretary of Defense for Nuclear, Chemical and Biological Defense Programs. Fortune article: fortune.com/2026/06/15/exc… Jobs: radicalnumerics.ai/join-us

@googrish Congrats Girish! Excited for fast RL training loops 🙂

“don’t train your own model” is common ai advice. it's wrong. your token bill's the proof. today, we’re excited to launch castform into open preview. castform is the easiest way for you to train your own model, on your own data. open-weights models are performant and much cheaper. when trained on your task & proprietary data, they beat closed models. the thing standing between you and that was weeks of plumbing & years of ml expertise. with castform, model training is as simple as prompt engineering. @castformai bring your agent traces or raw corpora. castform turns it into training data, picks the right algorithmic recipes, manages gpus, and gives you an ide to watch and chat with your model as it learns. see what you can build with castform👇

Also published back-to-back with Google Co-Scientist 🎉 Big congrats to @vivnat, @_e_d_v_, and team — excited to see what comes next!

My first PhD paper is out now in @Nature! Very grateful to have worked with the FutureHouse team on this, and a big shoutout to my co-first author @agreeb66 😀

@catherinehyeo @evatuecke @GreylockVC @neo @BoxGroup @Liquid2V @JeffDean Congrats Catherine and Eva!!

Introducing Altara: the scientific intelligence platform for the physical world. Today @evatuecke and I are excited to announce our $7M seed led by @GreylockVC, joined by @Neo, @BoxGroup, @Liquid2V, and angel investors including @JeffDean and leadership from OpenAI & AMD. We’re already working with early customers in semiconductors, batteries, and advanced materials. More below.

We used AI to predict the failure of a Phase 3 trial before the results were announced. Today, we're publishing 10 more predictions for the future. Thread 🧵

This is exciting; I expect we are going to see a lot more things like this and it will be one of the most important impacts of AI. Congrats to the Future House team. edisonscientific.com/articles/annou…

This post made me so happy to read! "It is an understatement to say I was impressed...Kosmos is causing me to re-imagine what my career will look like." I've had a few moments like this myself while working on Kosmos and I'm grateful to hear that it's helping scientists already 🙂

Kosmos, our newest AI Scientist, is available to use today on our platform. Watch here as three of our scientists describe what Kosmos is, and how it can accelerate scientific research.

After two years of work, we’ve made an AI Scientist that runs for days and makes genuine discoveries. Working with external collaborators, we report seven externally validated discoveries across multiple fields. It is available right now for anyone to use. 1/5

Today, we’re announcing Kosmos, our newest AI Scientist, available to use now. Users estimate Kosmos does 6 months of work in a single day. One run can read 1,500 papers and write 42,000 lines of code. At least 79% of its findings are reproducible. Kosmos has made 7 discoveries so far, which we are releasing today, in areas ranging from neuroscience to material science and clinical genetics, in collaboration with our academic beta testers. Three of these discoveries reproduced unpublished findings; four are net new, validated contributions to the scientific literature. AI-accelerated science is here. Our core innovation in Kosmos is the use of a structured, continuously-updated world model. As described in our technical report, Kosmos’ world model allows it to process orders of magnitude more information than could fit into the context of even the longest-context language models, allowing it to synthesize more information and pursue coherent goals over longer time horizons than Robin or any of our other prior agents. In this respect, we believe Kosmos is the most compute-intensive language agent released so far in any field, and by far the most capable AI Scientist available today. The use of a persistent world model also enables single Kosmos trajectories to produce highly complex outputs that require multiple significant logical leaps. As with all of our systems, Kosmos is designed with transparency and verifiability in mind: every conclusion in a Kosmos report can be traced through our platform to the specific lines of code or the specific passages in the scientific literature that inspired it, ensuring that Kosmos’ findings are fully auditable at all times. We are also using this opportunity to announce the launch of Edison Scientific, a new commercial spinout of FutureHouse, which will be focused on commercializing our agents and applying them to automate scientific research in drug discovery and beyond. Edison will be taking over management of the FutureHouse platform, where you can access Kosmos alongside our Literature, Molecules, and Precedent agents (previously Crow, Phoenix, and Owl). Edison will continue to offer free tier usage for casual users and academics, while also offering higher rate limits and additional features for users who need them. You can read more about this spinout on our blog, below. A few important notes if you’re going to try Kosmos. Firstly, Kosmos is different from many other AI tools you might have played with, including our other agents. It is more similar to a Deep Research tool than it is to a chatbot: it takes some time to figure out how to prompt it effectively, and we have tried to include guidelines on this to help (see below). It costs $200/run right now (200 credits per run, and $1/credit), with some free tier usage for academics. This is heavily discounted; people who sign up for Founding Subscriptions now can lock in the $1/credit price indefinitely, but the price ultimately will probably be higher. Again, this is less chatbot and more research tool, something you run on high-value targets as needed. Some caveats are also warranted. Firstly, we find that 80% of Kosmos findings are reproducible, which also means 20% are not -- some things it says will be wrong. Also, Kosmos certainly does produce outputs that are the equivalent to several months of human labor, but it also often goes down rabbit holes or chases statistically significant yet scientifically irrelevant findings. We often run Kosmos multiple times on the same objective in order to sample the various research avenues it can take. There are still a bunch of rough edges on the UI and such, which we are working on. Finally, we are aware that the 6 month figure is much greater than estimates by other AI labs, like METR, about the length of tasks that AI Agents can currently perform. You can read discussion about this in our blog post. Huge congratulations to our team that put this together, led by @ludomitch and @michaelathinks: Angela Yiu, @benjamin0chang, @sidn137, Edwin Melville-Green, Albert Bou, @arvissulovari, Oz Wassie, @jonmlaurent. A particular shout out to @m_skarlinski and his team that rebuilt the platform for this launch, especially Andy Cai @notAndyCai, Richard Magness, Remo Storni, Tyler Nadolski @_tnadolski, Mayk Caldas @maykcaldas, Sam Cox @samcox822 and more. This work would not have been possible without significant contributions from academic collaborators @mathieubourdenx, @EricLandsness, @bdanubius, @physicistnevans, Tonio Buonassisi, @BGomes_1905, Shriya Reddy, @marthafoiani, and @RandallBateman3. We also want to thank our numerous supporters, especially @ericschmidt, who has been a tremendous ally. We will have more to say about our supporters soon!

Kosmos is available to use today on the Edison Scientific Platform! I’m very excited to see how you’ll use Kosmos and the science you may discover. A huge shoutout to @ludomitch, @michaelathinks, @andrewwhite01, @SGRodriques, Angela, and the incredible team at Edison for transforming Kosmos from a whiteboard sketch into a real system that scientists can use.

7⃣ Key Limitations 🔨 Kosmos runs require scientists to specify a research objective, and the output strongly depends on the quality of the objective, which is arguably the hardest part of research! 🔍 It is quite difficult to know what makes a good discovery — even the best scientists often disagree. Therefore, identifying truly valuable discoveries from a Kosmos run is time intensive and usually requires lots of expert feedback.

💡 Excited to introduce Kosmos, an AI scientist system for data-driven discovery! Kosmos is a multi-agent system designed around a central “world model” to coordinate information across hundreds of scientific agent instances. Given an open-ended objective and dataset, Kosmos can perform up to 12 hours of research to explore, analyze, and complete the objective. We present 7 expert-validated discoveries that Kosmos generated or reproduced across scientific disciplines, including: 🧠 A novel mechanism of ENT neuron vulnerability with aging 🔥 Identifying a critical determinant for perovskite performance 📊 Evidence that high SOD2 levels may causally reduce myocardial fibrosis 📄 Technical report: arxiv.org/abs/2511.02824