Honza
5.1K posts
@agingroy Wow, modern medicine is incredible. Still no cure or non-surgical treatment developed for endometriosis, but thank god scientists are busy ensuring bald men no longer will be forced to wear hats in the winter!
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For 28 years, if you were losing your hair, you had two choices. Minoxidil (a foam, works for about 1 in 3 men). Finasteride (a pill, works better but can cause sexual side effects). That's it. Nothing else since 1997.
Two new drugs just arrived, and they work in completely different ways.
This one (rezpegaldesleukin) is for people whose immune system attacks their own hair follicles. It retrains the immune system to stop.
In the Phase 2b trial, patients grew back scalp hair, and half also regrew their eyebrows and eyelashes. @US_FDA gave it Fast Track.
The other (clascoterone) is a cream for the common baldness men get with age. It blocks the hormone responsible, but only on your scalp.
No pills. No effect on sexual function. Tested in 1,465 people across two Phase 3 trials: more than 5x the hair growth of placebo.
87 million Americans deal with one of these two conditions. After nearly three decades with nothing new, both showed up in the same year.
Samuel Hume@DrSamuelBHume
There are some great case studies from the deck, too This is after 36 weeks with Nektar's Il-2 receptor agonist, Rezpegaldesleukin, in a patient with alopecia areata
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@NealWiser @Pinboard @Simberg_Space We are only slowly realising the devastating gravity of that treacherous mistake.
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@Pinboard @Simberg_Space We’ve done it before. In the 80s, Carl Sagan discovered that a nuclear war would end humanity in a “nuclear winter” which led to cooperation and serious arms control. Don’t get me wrong. What’s going on today is a sad joke, but the precedent was set.
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i wish the ending of project hail mary had shown how much living on erid affected grace like … he was walking with a cane at the end of the book because the gravity on erid is making his bones degenerate faster
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@DefiantLs Why are people SO RESISTANT to driving through the barriers. They are flimsy for a reason! The reason is so you can drive through them!
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is it just me or did I honestly expect a little more fanfare for Artemis II
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@PalmyrPar Some people complaining that the move “left out” too much from the PHM book are missing the fact that the movie studio actually did a pretty good job of story-editing; something that Weir didn’t get when he self-published and then subsequent work suffered for it
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Weir’s writing is atrocious, his dialogue even worse, but it’s undeniable that his genre of sci-fi competence porn with a heavy covering of pop-culture referentia should’ve garnered purely commercial interest from publishers looking to, y’know, make money.
Jon Del Arroz | Pop Culture & Gaming 🎮@jondelarroz
"I couldn't get a literary agent, I couldn't get a publisher interested..." Andy Weir, who has the biggest movie of the year with Project Hail Mary had to self-publish. It's because he's a white male. This is who's being gatekept even now. Do you see the pattern?
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@smellymittens @fandompulse Oblivion is preferable to the demonic necromancy they are doing with Trek.
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@fandompulse Except that now, because of all the whinny little star trek, man-babies, there will be no new trek in production. No movies, no tv shows, No nothing. Maybe everyone will begin to appreciate what they have while they still have it.
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Project Hail Mary writer Andy Weir savages modern Star Trek after they rejected his pitch:
“I pitched a Star Trek show to Paramount and I was in Zoom with the showrunners with all the shows and spent a lot of time talking to [executive producer Alex Kurtzman]. I don’t like a lot of the new Trek. He, as a person, is a really nice guy. But at the same time, those shows are shit. He is a nice guy. But they didn’t accept my pitch so, you know, fuck ’em.”
Should they have hired him instead of green lighting Starfleet Academy?
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@Ackermann_cz S tou normálností bych asi trochu brzdil, ale jinak jo.
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Proč když někdo vyfotí nějakou krajně levicovou skupinu, tak tam jsou 3 typy lidí:
1) muž, ze kterého je i přes obrazovku cítit marihuana
2) nebinární pansexuál
3) normální mladá žena
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@txtarheeldad @AGHamilton29 Get better insults what is that even supposed to mean. Downie eugenics is good and I'm glad I don't have to live around many of them. Most other chromosome errors abort themselves anyway.
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I remember being in complete shock when learning about Iceland’s plan to wipe out Down Syndrome by having a 100% abortion rate for any children who screen for it, which is essentially what they have now.
That’s the same way I feel about Canada’s MAID program.
It’s shocking that this stuff has become normalized in some supposedly civilized countries and there are people who will defend it as morally acceptable.
Tablesalt 🇨🇦🇺🇸@Tablesalt13
🚨NEW - CANADIAN SENIOR OFFERED DEATH FOR MINOR BONE BREAK 84-year-old Miriam Lancaster was admitted to a Vancouver hospital with a broken sacrum (small back bone) Her doctor told her: "We can offer you MAID.’ she refused and recovered in a month, later climbed a volcano.
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@realheinzsauce @fleshsimulator Like the other guy said, he has extremely high T actually. Probably some insensitivity to it.
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@txtarheeldad @AGHamilton29 Not when they get old and still have to be cared for by their elderly parents. Sweetest!? The're supposed to be people not pets.
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@AGHamilton29 Absolutely vile. Down Syndrome kids are the SWEETEST
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@HighwayToTheDZ @AGHamilton29 @Fred_On_X It's an error in the DNA transmission, not anything with the contents of it.
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@AGHamilton29 @Fred_On_X If Down’s syndrome is genetic, then the logical conclusion is to eliminate the parents, no?
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I ate a revolving sushi bar the other day and now I fully understand imperial Japan
If I was eating like this and then saw my Han neighbors eating pig guts, I would absolutely think they’re Asia-goyim
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@TheTriviaJockey @theisabelb And when Ministry propaganda is "there are no rape gangs" and "trans women are women"?
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@theisabelb Having a hard time believing you read the books.
Umbridge tried to force the status quo and would not tolerate any dissent from the Ministry’s propaganda. No tolerance for any other thinking. Demanded adherence to established doctrine.
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Just for the record, anyone who actually understands Harry Potter knows Dolores Umbridge would force you to write down “trans women are women” until it was etched into your skin.
Georgia Coley@artwithinpod
rewatching Harry Potter And The Order of The Phoenix and you kinda have to wonder now: does JK Rowling think the good guys in Harry Potter would be on her side today? does she think Harry, Ron and Hermione would be anti-trans? does she think Dolores Umbridge would be PRO-trans?
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You know, it's been forever since I watched these movies and it didn't strike me as weird at the time, but why the fuck is Dudley wearing an old-timey fancy boy straw hat.
PotterWorldwide@PotterWorldW
Completely different vibe with the Dursleys now compared to the Dursleys back then.
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