Jason Kay

@agingroy Human N=1 and case-report evidence shows plaque regression after strict plant-based interventions that would also sharply reduce Neu5Gc exposure. Separately, mouse models directly support Neu5Gc as a causal accelerator of atherosclerosis.

Atherosclerosis kills 20 million people a year. Statins slow plaque growth. Nothing approved today reverses it. Cyclarity just reported the first human evidence that oxidized cholesterol can be selectively removed from the body. Their drug, UDP-003, is an engineered cyclodextrin dimer with roughly 1,000-fold selectivity for 7-ketocholesterol (7KC) over normal cholesterol. In a Phase 1 trial of 72 healthy volunteers at Monash Victorian Heart Institute (NCT06813339), it showed dose-dependent urinary excretion of 7KC, a 3-hour half-life, no serious adverse events across all dose levels, and no bioaccumulation. 7KC is an oxidized form of cholesterol that accumulates in arterial plaque and converts macrophages into foam cells. Foam cells are the building blocks of plaque. In preclinical work, removing 7KC with UDP-003 reversed foam cells back to functioning macrophages in 15 minutes. This program grew out of @aubreydegrey's "damage repair" framework for aging. @vitadao, a decentralized science DAO, was one of 12 investors. The lead investigator, Stephen Nicholls, ran some of the largest cardiovascular imaging trials in the field. This is still Phase 1. Safety, not efficacy. The exact quantities of 7KC excreted weren't disclosed, and plaque regression hasn't been demonstrated yet, not even in animals. An ACS patient cohort with pre/post coronary CT imaging is enrolling now. Phase 2 (plaque regression as primary endpoint) is planned for late 2026. Historically, roughly 8% of Phase 1 drugs reach approval. If it works, this would be the first drug that removes the toxic material inside plaque rather than just slowing its accumulation. That's a different category of medicine.

Please tell me you guys are checking testosterone levels in the morning and not the afternoon/evening… Testosterone has a strong diurnal rhythm, especially in younger men, and late-day labs can look artificially low. Also, “optimal” is not automatically 800–1000 ng/dL. For many men, symptom relief occurs well below that, and pushing levels too high can create its own problems depending on hematocrit, blood pressure, lipids, estradiol response, sleep apnea risk, fertility, etc.

It's the end of an era -- at 45 years old, my 'natty status' is now over. I've always been 100% transparent online, so this will be no different. Yesterday, I took my first shot of TRT. I've never been against test, on the contrary. I've always been pro-whatever makes you feel better and gives you a higher quality of (healthy) living. That includes test, GLP/peptides, HGH, whatever. If it genuinely improves your quality of life and doesn't shorten your estimated life span, live and let live. I've also always had dismal free test numbers, ever since I first had them tested when I was in my early 30's. Every time I test them, they're barely over 300. Even when EVERYTHING is dialed in - 10% body fat, super strong, not drinking, no drugs, no booze, no porn, literally raw dogging life... my test numbers wouldn't budge. At first, I didn't care. I didn't have any symptoms of low test. I had plenty of energy. I got really strong. I build muscle just fine. I had a high libido. Zero issues. But in the last 6 months or so, something has felt... off. I should be thrilled about everything. Great life. Great career. Getting close to financial independence. Awesome/hot wife. 2 great kids who get awesome grades and are respectful. Living the dream, right? But I would still struggle to get out of bed. Be in a bad mood for no reason. Let little things stress me out. See the gym as a chore rather than be excited to go. Had some pretty bad anxiety at times. I've talked to a number of other men who have felt the same, and have gotten a lot of relief from test. So, we're giving it a go. I'll report back. Gonna try to get my levels to the 800-1000 range, somewhere in there. Around 3x what they currently are. I would imagine that will make a difference. So, RIP, natty status. It's been real. Even if nobody believed you were true.

@LeonBrass @nypost Maldives is amazing with some of the best diving in the world.

@nypost Mal Dives

5 dead in 160-foot Maldives scuba dive - worst diving accident nation has ever seen trib.al/CgL7v4Q

@nassyweazy > I independently third party test all my purchases and filter all my vials, and so should you. Can you explain this bit?

40 POUNDS LOST IN 6 WEEKS!! Retatrutide is the ultimate cheat code not just to lose weight, but to lock in and build the healthiest habits. Some data after week 6: • Body Weight: -15.3% • Visceral Fats: -33% • BMI: -5.1 • Body Fats: -36.5% • Strength: ~10/15% heavier weights • Resting Heart Rate: +20 bpm • Lean Mass: -8lbs (also included water from retention) Brain fog is entirely gone, all inflammations, joints, and back pains are gone as well. Mental focus has more than doubled. My protocol (not seeking feedback): • 15,000+ steps a day • 40 mins cardio a day • 1h30-2hr weight lifting a day • 16-18hrs intermittent fasting • Protein-heavy bowl / salad for lunch • Chicken heavy dinner • No alcohol • Tons of water & electrolytes My current peptide stack: • Retatrutide: started at 2mg weekly, but went down to 1.5mg as it was too strong for me • Tesamorelin: 2mg daily fasted on evenings 3 hours after dinner (2 weeks in) • MOTS-C: 5mg 3x a week, fasted, right before morning workout (2 weeks in) • SS-31: 5mg daily on evenings (2 weeks in) Note: I independently third party test all my purchases and filter all my vials, and so should you. To avoid any loose skin, kessa w/ traditional Moroccan hammam technique twice a day. Painful but the goal is to activate mechanotransduction, fibroblasts, keratinocyte turnover, inflammatory cytokines, and collagen repair pathways. Result has been 0 loose skin for me. Tesamorelin is helping a lot when it comes to enhance visceral fat targeting, HGH production, and sleep. It's only been less than 2 weeks on it but I can already feel the benefits. Ultimately, reta is the perfect push that anyone with intense food cravings, noises, or disorders can use to reset entirely. It makes it incredibly easy to lose excessive appetite but also shed fats. I just wish I'd started sooner, this was all I needed as motivation. Peptides are the future and Eli Lilly will print trillions.

Nick is not too young to show soft plaque after seven years of having a cholesterol of 700 mg/dL. His n=1 case report DOES tell us something incredibly important. In 1953, it was shown in 300 autopsies of American soldiers who died in the Korean war with a mean age of 22 that 77% had plaque and 15% had luminal narrowing. Nick is in his 30s so it is expected for him to have some soft plaque even without extremely elevated cholesterol. Causation can either be necessary, sufficient, or necessary and sufficient. Nick’s n=1 case shows all on its own that 700 mg/dL cholesterol and its associated high LDL-C and ApoB is not sufficient to cause atherosclerosis. It may still be necessary to have high LDL-C or ApoB. In fact, Nick could be the only person on the entire planet who is missing one other factor that, once combined with high LDL-C or high ApoB, is sufficient to cause plaque. As such it is possible that Nick’s results do not apply to any other person on the planet, when looking at his case report alone. But that’s totally different from saying we can’t learn a principle from his case report that we know does translate to everyone else. The principle is that high cholesterol is not sufficient to cause heart disease. The reason we don’t know if his report generalizes to other people is not because we don’t know if we can generalize that one principle. It’s because we don’t know how Nick is different from other people and we therefore don’t know if anyone else has the same mix of relevant factors. In other words, it does matter that his n is 1 because for this reason we can’t make a probability statement about the likelihood that someone else can maintain this high cholesterol for the same period of time without showing plaque. But that’s separate from the point that it only takes a single cause of A coexisting with lack of B to show that A is not sufficient to cause B. That’s assuming you measured A and B correctly. Now if we move beyond his case report we can go back to the research showing LDL requires damage to be taken up into plaque and facilitate disease progression. Maybe Nick is lacking that damage. Also, the characterization of the LMHR phenotype is suggestive of a generalizable principle connecting Nick with these other folks. It needs a lot more research. But the point that 700 mg/dL cholesterol for seven years coexists with no plaque is a major demonstration of the insufficiency of high cholesterol or ApoB to cause plaque.

The saddest thing in the world is not poverty; it's loss of dignity

@CoachDanGo just drink San Pellegrino all day long get ur calcium in

Once you're making serious money: - Hire a health coach - Get a house manager - Invest in a high quality mattress - Get someone to prep your meals - Install a reverse osmosis water filter - Buy a stand up desk and under the desk treadmill Invest in your health to level up.

@lobotomy_user Wearing it on the same wrist as my Apple Watch

he’s a 10 but he’s genuinely excited to buy the swatch x royal oak as his first watch

I wish this was fake but residents near Driscoll’s berry farms report a 38% higher incidence of childhood cancer. Santa Cruz County is the heart of California's $3B strawberry industry and home to Driscoll's world headquarters. Coincidentally, it also has the second-highest childhood cancer rate of any county in California. At 22.5 childhood cancers per 100,000 children, the rate is more than 38% above the statewide average of 16.3. Over 5,060 acres of pesticides linked to those same cancers are sprayed in the Pajaro Valley every year to grow 40% of California's strawberries. Worst of all, it’s often next to schools and homes where children spend most of their time. According to the latest data, over 2,000,000 pounds of pesticides were applied just in this school district’s area alone. Driscoll’s is reported to apply two together: 1. 1,3-D: fumigant used to sterilize the soil, officially listed by the state as a carcinogen, causes tumors in multiple animal studies 2. Chloropicrin: originally deployed as a chemical weapon in World War I, so toxic that it kills or disables test animals before scientists can even evaluate its long-term carcinogenicity But yeah it’s probably just a coincidence all the kids are getting cancer? This is why you need to be buying local and seasonal fruit. Do not trust major corporations to do the right thing for our food or health.

@DesolateCS @SOU_BTC Oh you've got an AP? Me too! I have a collection...

@SOU_BTC I'm going to start saying "nice swatch" to every gen AP I see.

Audemars Piguet x Swatch、最高に資本主義っぽい。 普通の人には「手が届くロイヤルオーク感」を売り、本物勢には「俺のは本物」という優越感を売る。 無課金勢と廃課金勢を同時に満足させる、本物APおじさんが一番喜ぶコラボ説。

@RogerSeheult Yayyyy tasty high blood pressure

Fruit flavored vapes is a thinly disguised grab at imprisoning junior high in high school students to a life of nicotine slavery.

@WarMonitor3 90s EZ. No Cold War + pre 9-11. People still existed in the real world for the most part.

What time period was the best to live in and why?

@tanpukunokami Some are quite picturesque!

Japan has police boxes everywhere. They're called koban. Tiny ones on street corners, run by a few officers in shifts. About 14,000 across the country if you count the rural ones too. You go there for stuff like asking directions, turning in a wallet you found, or reporting something. Honestly, a lot of people just stop by to say hi. The officers walk around the neighborhood. They know who lives where. Kids wave at them on the way to school. Singapore copied the whole system in 1983. Their crime rates dropped. Brazil and parts of the US have done the same. Japan didn't make policing better. They made it friendlier. 🇯🇵

The Mullas regime is dumping oil into the Gulf! They kill people and now they’re destroying the environment too. This is seriously dangerous!

New Emirates first class interiors are sublime! Arriving home in luxurious comfort 💪🇦🇪

Psyllium lowers LDL by about 13 mg/dL across 28 randomized trials. The mechanism gets misrepresented constantly. It does not absorb cholesterol. It does not scrub the gut. The mechanism is purely mechanical, and understanding it explains why most other "soluble fibers" do not produce the same effect. Psyllium is the seed husk of Plantago ovata. When it hits the small intestine and hydrates, it forms a viscous gel. That gel physically traps bile acids, the cholesterol-derived molecules your liver releases through the bile duct to emulsify dietary fat. Normally about 95% of bile acids are reabsorbed in the ileum and recycled back to the liver. The pool cycles 4 to 12 times per day, losing about 5% per pass. The recycling is efficient because synthesizing new bile acids is expensive. The substrate is cholesterol. When psyllium disrupts that recycling, the liver loses inventory. Loss of FXR-mediated feedback upregulates CYP7A1, the rate-limiting enzyme in bile acid synthesis, which depletes the hepatic cholesterol pool. SREBP-2 activates, LDL receptors get upregulated, and hepatocytes pull LDL from circulation to refill it. Serum LDL drops. This is the same mechanism used by prescription bile acid sequestrants like cholestyramine. Jovanovski et al. (2018, American Journal of Clinical Nutrition) pooled 28 randomized controlled trials covering 1,924 participants. The median dose was about 10.2 grams of psyllium per day. LDL fell by approximately 13 mg/dL. Non-HDL fell by approximately 15 mg/dL. ApoB, a more direct measure of atherogenic particles, fell by 0.05 g/L. The apoB evidence was graded as high quality. Two things matter. First, the mechanism is purely mechanical. Psyllium is not metabolized, does not enter circulation, does not act on a receptor. That is why it has a clean side-effect profile and does not interact with the cytochrome P450 system the way most lipid-lowering drugs do. Second, viscosity is the active property. Inulin is also classified as a soluble fiber under FDA rules, but inulin does not form a viscous gel. It is highly fermentable instead. The label calls them both soluble fiber, but their functional profiles share almost nothing. The honest framing on magnitude. A 13 mg/dL drop is meaningful but modest compared to even the lowest-dose statin, which typically delivers 25 to 50 mg/dL. If your numbers are borderline and you want to avoid medication, psyllium is one of the few interventions with this level of evidence. If a statin is indicated, psyllium is not a replacement. Practical: target around 10 grams of psyllium husk daily, taken with or just before a meal with a full glass of water. That matches the Jovanovski median. Many trials dose 7 grams two or three times per day for a larger effect. Start at 5 grams and titrate up to manage GI side effects. Jovanovski et al., Am J Clin Nutr, 2018 McRorie & McKeown, J Acad Nutr Diet, 2017 Gonzalez, Compr Physiol, 2012

You don’t really understand the love for Dubai and the UAE. Until you experience living here 🇦🇪

@tanpukunokami Not to mention the clean public restrooms at every transit station!

In most countries, you have to buy something to use the bathroom. In Japan, you don't even need to be a customer. 3 AM. A foreigner walks into a 7-Eleven, desperate. "Toilet… please?" The cashier just nods: "Hai, dōzo." Free. Clean. Heated seat. Music in the stalls. No purchase. No questions. And he still bows on the way out. Welcome to Japan. 🇯🇵

It’s simple: stand with the UAE or stand with the evil Iranian regime and the IRGC. No middle ground anymore. No mediators, no silent allies. We’ll defend ourselves and strike back at every terrorist attack !! Choose your bloody side!

@Jaytel Acts like a junior dev adding debug log entries everywhere and trying the same thing over and over while Codex reads the code and one-shots it.

4.7 is completely unusable