Jihoon William Lee

Research from Virchows Archiv reveals that lymphoid proliferations can mimic renal carcinomas. The study emphasizes the importance of considering these conditions in the differential diagnosis of kidney masses to guide appropriate management. bit.ly/4kAyg1T

This is the first reported case of a right-sided splenic heterotopia massive enough to cause symptoms. The mechanism of its formation is unclear and worth exploring further. Thanks to Dr. John L. Gore @uwurology and @Tretiakova_Mar @uwlabmedpath for their guidance. (2/2)

Presenting a woman who presented with urinary symptoms and a remarkably large right renal mass suspicious for renal cell carcinoma. Analysis of the mass revealed it was in fact heterotopic splenic tissue. doi.org/10.1177/106689… (1/2)

This work is the product of many colleagues’ much appreciated efforts. Many thanks to members of the @HutchGreenberg Lab and the Shared Resources facilities at @FredHutch. (5/5)

These TCRs demonstrated enhanced targeting of HLA-A2+, G12V KRAS tumors. Our findings highlight the potential impact of post-translational modifications of tumor antigens on immune recognition and clarifies approaches for therapeutic TCR development. (4/5)

Excited to share a preprint resulting from some of my PhD work in the @HutchGreenberg Lab, addressing therapeutic targeting of post-translationally modified mutant KRAS presented by a common Class I HLA molecule. This work focuses on adoptive cell therapy with TCR-T cells. (1/5)

Happy to share my review on constraint-based #metabolic modeling! It covers #Python packages for these analyses and how they can be applied to #cancer research. Many of these tools are from the @open_cobrapy project. doi.org/10.3389/fonc.2…

The immune cells of individuals with COVID-19 show metabolic changes, according to a @NatureBiotech paper. go.nature.com/3tCimuh

Just published @NatureBiotech A unique single cell multiomic study in ~200 people with Covid-19 and assessment of over 1,000 metabolites nature.com/articles/s4158… @jihoonwlee @UW @MCBSeattle @fredhutch @isbsci @LabHeath @SuYapeng @Swedish

We received funding support from the generous Wilke Family Foundation, @MurdockTrust, @GileadSciences, @Swedish, @parkerici, @Merck, Biomedical Advanced Research and Development Authority, @NIH, @HHSgov, @ASPRgov, @NIAIDnews, @fredhutch, and @UW. (8/8)

This work was also made possible by the support of institutions: @isbsci, @fredhutch, @UW @UW_MSTP @UWMedicine @MCBSeattle @UWBioE, @Stanford @StanfordMed, @Swedish @Providence, @parkerici. (7/8)

Excited to share our new #multiomics work examining heterogeneous cell type-specific #metabolic changes associated with disease severity/survival in the #immune response in #COVID19. Great collaboration with @SuYapeng at @LabHeath and @HutchGreenberg (1/8) nature.com/articles/s4158…

Hope the science we discovered will be inspiring to the cancer field to rethink about drug resistance! The cancer cells are able to reach resistance via many paths. Single-cell resolution view can unearth so much previously unknown but important biology!