@IdoAmitLab @CellCellPress @MVLocquenghien @PascaleZwicky @CuriousKX Brilliant approach to make use of the specific expression of MMPs by TAMs in the TME! Congrats! @MVLocquenghien @PascaleZwicky @CuriousKX @IdoAmitLab
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Maximilian Schaefer
60 posts
Maximilian Schaefer
@m_mschaefer
PhD student @miriammerad @icahnmountsinai | BIF fellow | alumni @eth_en @sallustolab @becherlab @fu_berlin
Zurich, Switzerland Katılım Ağustos 2022
446 Takip Edilen118 Takipçiler
Excited to share our study @CellCellPress introducing a novel class of macrophage-targeted immunocytokines (MiTEs) that engage myeloid, T and NK cells to boost anti-tumor immunity in solid tumors. Led by @MVLocquenghien, @PascaleZwicky & @CuriousKX (1/16)
cell.com/cell/abstract/…
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Maximilian Schaefer retweetledi
#ScienceSaturday
❓ Why do some cancers resist immunotherapy?
➡️ A recent study in Nature found that certain cancers can “trick” the body’s immune system. They do this by changing how cells in the bone marrow develop. These changes cause more immune cells called macrophages to form — but these macrophages actually block the immune system from attacking the tumor.
➡️ Lung cancers cause this change by stressing cells in a way that activates a protein called NRF2. This reprogramming creates macrophages that protect the tumor instead of fighting it.
➡️ The researchers found that blocking NRF2, through drugs or genetic changes, lowered these protective macrophages, boosted immune cell activity and made immunotherapy work better. This suggests a new way to improve treatments for cancers that usually resist immunotherapy.
🌟 Congratulations to senior author Miriam Merad of the Icahn School of Medicine at Mount Sinai, and collaborators at Institut Gustave Roussy, Harvard Medical School and others for advancing this critical work. @MiriamMerad @SinaiImmunol @IcahnMountSinai
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Big congrats, Flo! Fantastic new tool to analyze high-dimensional flow data. @FlorianIngelfi1 @IdoAmitLab @YosefLab
Florian Ingelfinger@FlorianIngelfi1
🚨 New preprint! Generative modeling comes to cytometry. Meet CytoVI — a deep generative model from the @YosefLab & @IdoAmitLab for antibody-based single-cell technologies (flow, mass cytometry, CITE-seq). doi.org/10.1101/2025.0… 🧵👇
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Thrilled our Perspective in @NatureAging is out! With @MatthewD_Park et al., we spotlight how aging reshapes RTMs and skews myelopoiesis–with consequences for healthy aging and cancer @MiriamMerad
Matthew D. Park, Ph.D.@MatthewD_Park
Our new perspective piece in @NatureAging from lab of @MiriamMerad @SinaiImmunol highlights the fundamental role for aging-related changes to resident tissue macs and myelopoiesis in both healthy aging and in cancer: nature.com/articles/s4358…
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New preprint out! 🚀Spearheaded by @ChiaraFalcomata we could show how pancreatic cancer cells evade the immune system by modulating their TME with the extracellular factors Serpine1 (PAI-1) and Serpinb2 (PAI-2)! #PertrubMap #PDAC
Chiara Falcomatà@ChiaraFalcomata
🚨 Our new #preprint is out! doi.org/10.1101/2025.0… We used #PerturbMap spatial functional genomics in pancreatic cancer to track tumor clone dynamics and uncover how extracellular factors like Serpine1 and Serpinb2 drive immune evasion. 🧵 (1/8)
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@LatorreDanielaa @ERC_Research @ArmeniseHarvard @MyUniSR @SanRaffaeleMI Congrats Daniela, fantastic news!
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Exciting times ahead!
@ERC_Research @ArmeniseHarvard
#ERCCoG
@MyUniSR @SanRaffaeleMI
🔗 Found out more here: lnkd.in/dqyBbYQh lnkd.in/diW-s_iH
Stay tuned—opportunities to join our team are coming soon!
Università Vita-Salute San Raffaele@MyUniSR
The @ERC_Research Consolidator Grants for 2024 have been assigned. In the Life Sciences field, 4 projects have been funded in Italy, 3 of which were awarded to San Raffaele. Congratulations to our researchers! 🎉
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Maximilian Schaefer retweetledi
So excited to share our new paper out in @Nature led by the fabulous @AnaisElewaut and @guillemxtivill providing mechanistic insights into anti-tumor immunity and why it may fail in so many patients! Sky-torial on @obenaufa.bsky.social rdcu.be/d1F7s
IMP@IMPvienna
#Immunotherapy has transformed #cancer treatment, but some cancers evade immune defenses, causing resistance. @obenaufa's lab has discovered how inflammatory monocytes—a type of immune cell—can reactivate cancer-killing T cells within tumors. Read more: imp.ac.at/news/article/a…
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Maximilian Schaefer retweetledi
Another @preprintclub Journal Club by Zi Yan Chen & @nkg2d1 @ImmunologyUofT discusses @biorxivpreprint by @VillarVesga et al. @BecherLab @SarahMundt5 showing that monocyte-derived cells in CNS produce mitochondrial ROS to promote neuroinflammation
bit.ly/495E7HP
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As science twitter is moving to where the sky is blue: bsky.app/profile/mmscha…
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Fantastic @SinaiImmunol retreat on neuroimmunology–neuron-immune/immune–neuron interactions #CGRP #TRPV1
Thanks for organizing
@itchdoctor @michel_enamorad @MiriamMerad
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@FadiSheban Congrats Fadi!!! Wish you all the best for the future and your postdoc in Switzerland!
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It was hard to say goodbye to the Amitlab family! Forever grateful to everyone, especially Ido, for the friendship, support, and great times. I couldn’t have asked for a better place to help me grow and push boundaries. Excited for the next chapter, and I'll miss you all dearly❤️
IdoAmitLab@IdoAmitLab
Celebrating @FadiSheban 's PhD and moving to a postdoc at @randall_platt The lab has lost its ❤️. Fadi was inspirational in his creativity, energy & passion.
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Maximilian Schaefer retweetledi
Macrophages do a whole lot more. They are a major subunit of basically all tissues. They protect the brain from damage, regulate thermogenesis in adipose tissue, and are electrically coupled to cardiomyocytes in the heart. They are the immune system's ultimate Swiss Army knife!
Science girl@sciencegirl
White blood cells eradicating pathogens
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Maximilian Schaefer retweetledi
Check out our most recent work resolving a longstanding controversy: which phagocyte subset drives oxidative damage in neuroinflammation? Thank you for the support and the mentoring @SarahMundt5. Thanks to Mundtlab, @BecherLab and all coauthors! Link: biorxiv.org/content/10.110…
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@DergunStanislav Stimulating weekend 🤝 looking forward to your next visit!
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Life changing trip. Huge thanks @m_mschaefer for hosting. Wish to see you very soon 🫶🏻 #workinprogress
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Maximilian Schaefer retweetledi
It was a privilege to represent @MiriamMerad lab and share our newest story on cancer and aging at #CICON24. Major thanks to @CancerResearch for this major opportunity!
Read about our study now out @ScienceMagazine : science.org/doi/10.1126/sc…
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@MatthewD_Park and co have come up with another fantastic story: the role of IL1a and DNMT3A in hematopoietic aging and how it affects cancer immunity. Congrats @MatthewD_Park @MiriamMerad @TischCancer @IcahnMountSinai @SinaiImmunol
Matthew D. Park, Ph.D.@MatthewD_Park
Thrilled to share our first study on aging from @MiriamMerad lab @IcahnMountSinai @TischCancer @SinaiImmunol in which we demonstrate how aging promotes cancer. We show that: (1/n) science.org/doi/10.1126/sc…
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Thank you, Ido! I couldn't have asked for better or more supportive mentorship for my PhD journey. I enjoyed every chapter of it, thanks to you and the entire wonderful Amit lab!
IA@IA56830777
@IdoAmitLab @FadiSheban Congratulations Fadi for this amazing journey, it was an honour to mentor and work with you. Your thesis is a unique foundation for tumour macrophage biology
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Check out our most recent article about environmental impacts leading to CNS entry of CXCR3 B cells in MS! Big thanks to everyone for making this possible.
@BecherLab, @MS_TWIN_STUDY, @SarahMundt5, @UlutekinCan, @LukasRindlis
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@FlorianIngelfi1 @BecherLab @MS_TWIN_STUDY @SarahMundt5 @UlutekinCan @LukasRindlis Congrats @FlorianIngelfi1 and @UlutekinCan !!
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Happy to see this story out – brilliant idea and execution! Love the coupling with scRNA-seq. Congrats @victora_lab and collaborators! 💄
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