Matija Čupić

@garrytan What’s the ballpark estimate of how many tokens are you using per week / month? I don’t want to try GBrain because I might like it but not be able to afford the tokens 😭

The AI psychosis is spreading guys 👀

We’re bringing Jensen Huang to Startup School for a fireside chat with @garrytan! From co-founding @nvidia in 1993 to building the backbone of the AI era, Jensen helped turn GPUs into the engine of modern computing. Apply to attend: events.ycombinator.com/startup-school…

@ritwikpavan What benefit does this have over existing FotoFinder systems? I’m not familiar with how Swan works, but it seems more expensive, more complex, and less comprehensive than current gen FotoFinder systems. 🤔

JUST IN: Skin exams are getting automated. SquareMind just raised $18M to build a robotic system that scans your entire body and tracks every mole over time. • Swan robot captures full-body dermoscopic images in minutes • Tracks new and changing spots across visits • Replaces spot-check exams with total skin coverage • Creates a time-series record for earlier melanoma detection • Plugs directly into dermatology clinics Robotics is going to reshape healthcare.

@forgebitz How did you end up deciding to use Cursor as your go to AI agent harness?

promptwatch devs are the top 1% cursor users apparently (we are hiring)

@andruyeung Yes! Lovable's not even close to making their product seamless for non-technical users. This is a huge gap in the market. Bring AI to the masses!

Only 0.3% of the world pays for an AI service. There is a massive opportunity to build AI for ‘normies’ — the everyday person who is not plugged into Silicon Valley but can still benefit from what AI has to offer. And I think in-person experiences are the best way to do it.

@garrytan Food production is one of the most undisrupted markets, IMHO. The disruptions that did happen, all had a net negative effect on the health of humans…

Everybody eats. Improving our food supply and safer more efficient agriculture is one of tue most direct ways for AI to help people

@forgebitz See, I thought the same thing about code review. AI review was mostly a gimmick. Until Claude launched Ultrareview / hosted GitHub reviews. It’s, on average, nuanced as much as a human review is. It’s only a matter of time…

custom support is solved by ai until you have to speak to ai customer support and realize is completely useless and a very hard problem to solve

@Mow_exe @1realFormula There’s no cheese in that image 😅

@1realFormula Bro thinks American cheese is healthy

What’s this logic 😭?

@bryan_johnson What did you biopsy if there are no polyps or suspicious lesions?

I got put under and had probes inspect my gastrointestinal tract. Down my throat and up the anus. It was my first bidirectional endoscopy. Right before the anesthesiologist injected, I thought "This is the end. This is how I die. What could make the internet happier?" Then it was lights out. This was important to do because colon cancer is now the #1 cancer killer under 50, and rising fast. Early onset colorectal cancer incidence has more than doubled since 1994, climbing roughly by 3% per year in 20 to 49 year olds and 8% in 20 to 29 year olds. Even though I routinely do all sorts of painful things to my body and mind for this project, this procedure had been weighing on me. I didn't want to go under and, you know, didn't love the idea of the probes being snaked through my body. Glad it's over and it honestly was not as bad as I had anticipated. Here are my results: + doctor gave me a 10/10 score + no polyps + no inflammatory bowel disease + no diverticulosis, a common colon-aging marker + we are awaiting biopsy results Colonoscopy screening can save your life. A meta-analysis of over 4.7 million people found colonoscopy was associated with 52% and 62% reduction in colorectal cancer incidence and mortality. A regular full body MRI (I get one every 6 months) can't reliably detect early colon lesions or polyps. A colonoscopy remains the gold standard for both detection and removal. The recommended screening age has been lowered from 50 to 45 in 2021. Half of early colorectal cancer cases now fall in 45 to 49 year olds. Obesity is a genuine colorectal cancer risk factor. A meta-analysis involving over 66,000 participants found obesity raises early colorectal cancer odds by roughly 50%. Yet it is unlikely to fully explain the under 50 surge. A new study surfaced an unexpected culprit. Across 10 cohorts and 29 lifestyle and environmental signatures, comparing tumor DNA methylation in early-onset (<50) vs late-onset (≥70) colorectal cancer, one signal stood out: the herbicide picloram. Early onset tumors showed ~3 fold higher odds of carrying the picloram methylation signature in the discovery cohort, and 1.77-fold across all 10 pooled cohorts (114 early onset vs 372 late onset). Across 94 US counties over 21 years (1992 to 2012), picloram-use intensity correlated with increase in EOCRC incidence, the most robust signal among 62 pesticides tested. Early onset tumors carried a lower obesity methylation signature than late onset, suggesting that environmental toxins, more than metabolic dysfunction, are the dominant epigenetic driver in young patients. Epigenetic drift drives biological aging and most age-related disease: chemicals assumed safe because they aren't directly genotoxic may still predispose us to cancer and chronic disease over decades through methylation and gene-expression disruption It's time to ring the alarm: every additive chemical in our food, water, and environment needs re-evaluation through a long term, population-based epigenetic and gene expression lens, not just acute genotoxicity assays Epigenetic disruption by environmental toxins is likely a key driver.

Some pics from when Jensen delivered the first @Nvidia AI system to @OpenAI

@brightafia That’s cool. Totally viable. But how do you get to 180g-190g of protein, which is a more realistic target for most men that do weights? 2-2.2g / kg bodyweight. That’s almost 8 eggs and 400g of yoghurt a day. Not very viable.

HOW TO HIT 100g PROTEIN WITHOUT SUPPLEMENTS • 4 eggs — 24g • 150g chicken — 45g • 1 cup beans — 15g • 200g yogurt — 20g No powders. No excuses

@shawmakesmagic The impression that I have is that YC mostly judges the people on an application, not the idea itself. Ideas change, most startups pivot, but you still need a rock star team to pull through all of that.

Ironically I applied to YCo once with this idea and they rejected me I would never apply again, just giving Garry your ideas for free so he can vibe code and claim credit out of ignorance for an industry he himself gatekeeps

@michael_chomsky The engineer that wrote it ships it…

Ok how tf do I review this PR?

@hthieblot I built a tool that automatically posts what youre building to X - github.com/matteeyah/port… Shame that X charges for posting, even at a low volume, via the API

The longer I'm on X, the more I realize: Founders with small accounts are the most interesting ones. - too busy building to posture - 0 Ego, they just wanna win - keep posting with 0 likes - the world isn’t rooting for them yet but I will Tell me what you are building

@bstaples @sytses I _love_ GitLab. Use it daily. But it’s sooo behind the curve on AI, it’s not even funny. They should just drop most of what they’re working on and focus exclusively on making AI their bread & butter offering.

For those teams looking for alternatives to the GitHub meltdown, check out this recent customer chat I had with the software team behind Rivian/Volkswagen. They run GitLab dedicated, which means they get all the benefits of SaaS, but with dedicated infrastructure and isolation at enormous scale. One of the keys to our success: you are always in control of how and where you run GitLab. GitLab serves more than half of the fortune 100, and hundreds of thousands of other organizations around the world, why not yours? x.com/bstaples/statu…

@Txp_RBI_Xctuxl @paulg It’s definitely trending the same way BMW is, but it still has flagship models with the classic Mercedes look & feel

@matteeyah @paulg Yeah, about that...

The reason BMW and Mercedes design language has gone from understated class to this cartoonishly gaudy look is because China is one of their biggest markets. It's spiritually 3rd world. It's African dictator tier.

@dr_ericberg Nutrition and cholesterol. It’s the number one cause of death worldwide. It’s not that it’s misunderstood - but the whole world is being on eating wrong for some reason.

Which health issue do you think is misunderstood the most?

@Leooweb3 Not really. I prefer big sedans.

If you had a $5M networth. Would you spend $250k on a Porsche 911?

@LxngevityLab Except not eating from evening to morning doesn’t actually trigger autophagy. It takes at least 24h of fasting to notice autophagy. After 48h it should be more pronounced.

🚨 Eating 3 meals a day is accelerating your aging. David Sinclair exposed it: