@elonmusk @afshineemrani @lsanger We might solve the population collapse issue. If we can get along long enough to get there. 🙏
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Modern Engineer
1.6K posts
Modern Engineer
@Modernengineer
Engineer. Lover of science. Ad Astra 💫
Katılım Ocak 2026
820 Takip Edilen1.5K Takipçiler
I'm a cardiologist. Everyone is sharing this study as a skin story. They're burying the part that matters.
Scientists took the aorta of a 75-year-old donor, applied a single engineered enzyme, and stripped away more than 70% of the molecular damage — bringing it down to the levels you'd see in a 30-year-old artery.
Published five days ago in Nature Communications. Revel Pharmaceuticals, with Calico and the University of Colorado.
Here's what they erased.
Sugar reacts with proteins in your body the same way heat browns bread — slowly, over a lifetime. It leaves behind a residue called CML, the most abundant advanced glycation end product in aging tissue. It welds itself onto collagen and elastin in your skin, your eye lens, and your arterial walls.
Two things follow. Your arteries stiffen. And CML latches onto a receptor called RAGE, which drives chronic inflammation — the exact fire I've been writing about for months as the engine of heart disease.
Since the 1980s this damage was considered permanent. Your body has no enzyme to remove it. Every existing approach only slows new damage from forming. Nothing touched what was already there.
So they built an enzyme that doesn't exist in nature. They screened 45,000 protein structures, then ran five rounds of directed evolution across more than 500 million variants until they had CMLase — a molecular lawnmower that oxidizes the CML off the protein and restores the original, healthy lysine underneath.
Not patched. Reversed.
Over 70% cleared from elderly arterial tissue. Over 55% from elderly skin — below the levels found in 31-year-old skin. 45-78% in lens proteins. The CEO said they expected 20% and were floored.
Arterial stiffness drives systolic hypertension, heart failure, and stroke, and I have no drug that reverses it. I can slow the process. I cannot undo it. This paper says undoing it may be possible.
The caveats are real and I won't skip them. This was done on donated tissue in a dish, not in a living person. No functional data yet — we don't know if that artery got measurably more elastic. Delivering a large enzyme deep into human tissue is a hard, unsolved problem. Clinical trials are years away.
But something considered permanent for forty years just came off human tissue.
We spent a century learning to slow aging. Someone finally figured out how to erase it.
Thank you @theallinpod @friedberg @chamath @pesottas
The All-In Podcast@theallinpod
Friedberg: New study shows enzyme reverses skin age from 70+ years to 31 Chamath: That’s a $2T market. Did Scientists Just Discover How to Reverse Skin Aging!? “CML is kind of the predominant molecule that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down. So these scientists set out to try and create an enzyme, an enzyme is a protein that breaks something down, that can break down CML. And so these guys kind of went out and they took the target, which is CML, and tried to figure out, ‘Okay, how do we actually degrade CML, clear that extracellular matrix, and reverse aging?’ They started to test it on the proteins that we would find in our body, casein, collagen, retinal proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97% of the CML, just degrade it away. And then they found several sites where they were able to degrade over 90%. And then they took actual human skin from elderly patients that had donated their skin, and they put this enzyme onto that skin, and they were able to eliminate 55% of the CML on the skin, basically reverse the skin's age down to the age of a 31-year-old, this is from greater than 70-year-old patients, just by putting this enzyme on the skin. And so it's kind of a groundbreaking demonstration of combination of AlphaFold, what's called directed evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins, do high throughput screening, and ultimately make a novel protein that doesn't exist in nature today that can do something pretty profound for human health.” Chamath: “It will be a trillion-dollar market. If you can create a cream…” Friedberg: “I mean, dude, if you could put this enzyme literally on your skin and have it absorb in…” Chamath: “Game over. That alone is $2 trillion.”
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@AndrewCurran_ That's interesting. Where did the story originate?
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Elon says the $52 billion GB300 order is not real, so I deleted the thread.
Elon Musk@elonmusk
@beffjezos This is fake news
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@SawyerMerritt This feels intentionally worded to cause a specific person distress. @farzyness
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Cybercabs with no steering wheels have started arriving in California.
Morgan@MorganHammar
Me checking out @Tesla @robotaxi Cybercabs in San Bernardino CA. @wholemars @farzyness @SawyerMerritt @TeslaBoomerMama I want one! They are amazing up close and personal. No steering wheels. Can’t wait for them to be unleashed.
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@timmerenginerd @FreddyLA7 Good question. According to research, the nitrates appear to have been carried into the cave primarily by groundwater rather than coming directly from bat guano, though guano may have contributed.
Link to the journal: journals.uchicago.edu/doi/abs/10.108…
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@FreddyLA7 @blacktypetb American Pharoah completed horse racing’s first *modern* Grand Slam at Keeneland in 2015, winning the Breeders’ Cup Classic after sweeping the Triple Crown.
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Our second stop in Kentucky. We were told that Kentucky is all about horse racing, so we went to Keeneland Racecourse and visited some of the horses. They sell for insane prices. It’s a sport we didn’t know anything about, but after talking to the people who showed us around and hearing how crazy it gets on race days, we decided we have to come back for a race here.🐎
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Nice little German link up in Nashville with @FreddyLA7 and his boys. So now you all know NO we are not the same person and yes, they’re a great group of lads 👏🏼🇩🇪🇺🇸
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@AJamesMcCarthy @BigImpactHumans The face I make when I see Starship launch. 🚀
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No matter who you are, you can’t make someone love you. You can’t force someone to feel something that simply isn’t there
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Beginning July 20, Claude Fable 5 will be included in all Max and Team Premium plans, at 50% of limits.
Pro and Team Standard users will continue to have access to Fable via usage credits, and will receive a one-time $100 credit.
Demand for Fable has been challenging to predict, which is why we rolled it out to subscription plans in stages, extending access several times as we secured additional capacity.
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@elonmusk @SciGuySpace It really was remarkable engineering. Automatically detecting that the rockets failed to ignite and shutting down the engines to save the vehicle was incredibly impressive.
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I don't invest in space stocks because I cover space companies, or pretend to understand irrational market moves. But the idea that a space company stock would fall after an abort, which actually saved the rocket shows the company's procedures work as intended, is pretty dumb.
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@NolensvilleVFL @NashvilleSC Of course, that‘s the reason we decided to stay for another day haha
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We spent our afternoon in Nashville visiting the Country Music Hall of Fame. As new fans of the genre, it was amazing to learn about the history and all the incredible stories behind it. Before today, we only knew about ten country artists. Now it feels like we know them all.
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JUST IN: NASA is preparing to test “synthetic hibernation” in healthy humans, potentially paving the way for astronauts to hibernate during missions to Mars.
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We've resolved an issue where Fable was not selectable as a model within Claude.ai or Claude Code for a 30 minute period.
You may need to restart Claude Code. If Fable is not your default model afterwards, you should reselect it with /model.
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