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Omer Bese
978 posts
Omer Bese
@mrbese
Energy Engineer × Operations. Unapologetic Vitalist, Blunt Pragmatist, Annoyingly Curious. 🎓Columbia | 🧑🏼💻 Tech-Founder 📍 LA
Los Angeles, CA Katılım Eylül 2009
2K Takip Edilen379 Takipçiler
@sohohouse your cancellation flow is illegal and requires multiple hoops to jump through. I need to get my membership cancelled ASAP and your team is completely unresponsive
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Please @chamath , It is one thing to capitalize on compliance tech for operational efficiency, but to dress up administrative software as a catalyst for "life-saving drug discovery" is either moral masturbation or pure incompetence. (if not a SPAC)
Even if you reduce the cost of document management to virtually $0, it wouldn’t move the needle on developing the life-saving drugs. The bottleneck isn't document management; it's broken financial incentives.
Life-saving drugs already exist on the shelves. Big Pharma just doesn't have any economic incentive to fund R&D to repurpose existing drugs. The biggest example is the HIV drug Truvada being repurposed as PrEP.
By the time it anecdotally became prominent in the LGBTQ community for prevention, the time left on the patent didn't justify the R&D spend for Gilead. It took public money to fund the trials that ended up saving millions of lives.
The perfect compliance software won't fix it. AI mapping existing drugs to new diseases will. I truly have more hope in @GoogleDeepMind and @AnthropicAI than any pharma company.
This creates a market of "financial orphans." Drugs like Aspirin (pain to heart disease) or Methotrexate (chemo to arthritis) proved that a molecule's best use is not always its first intention.
If a drug is already generic, no private company will spend the $100M+ on trials to prove a new use case. I am not sure if it's even legal as a C-Corp considering fiduciary duties to shareholders, let alone practically possible with CEO's wealth being tied to the stock price anyway.
I don't think faster FDA paperwork for new molecules is the priority problem; we need computational pharmacophenomics. We need agile companies using AI to cross-reference the 4,000+ approved drugs against 18,500+ known diseases.
Tons of data already exists just in side effects reports. But a human researcher is siloed. They don't know that a random side effect in their trial is actually the exact biological mechanism needed to cure a completely different disease. Nor is it the aim of their grant to figure that out.
AI connects those dots. It bypasses the broken pharma incentive structure entirely, and hopefully, Public Benefit Corp structures will do the rest. Kudos to @mcuban for initiating this trend with @costplusdrugs
Chamath Palihapitiya@chamath
Pharma companies are all about life saving drugs. But from the perspective of software, pharmaceutical companies manage and author a series of documents of ever-increasing complexity, accuracy and criticality. Viewed in this way, the operating system for the pharma industry can be reimagined as a content management platform that helps scientists and pharma execs manage pre clinical, clinical and post clinical development of drugs and their go to market. We are building this exact suite for a multi billion dollar pharma company. The result is more money spent on lifesaving drug R&D and a more streamlined interface with regulators because the documents required to move along their process are increasingly pristine and machine verifiable. This doesn’t just apply to pharma. We are doing similar things in manufacturing, finance, aerospace & defense and medical devices. 8090’s practice and our Software Factory platform excels particularly well in regulated environment where vibe coding won’t get the job done. If you want to see if we can help you, please be in touch. Sales@8090.ai
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Banning AI to protect cognitive skills is exactly like banning computers to protect the discipline of the typewriter. Computers encourage revision, while the typewriter punishes it.
AI is just the next evolution and the opposite of what you think; its highest utility is to increase your cognitive workout. It becomes your sparring partner, stress-tests your logic, finds your flaws, and pushes you to continuously iterate further.
Yes, a student copying a first-draft AI output is doing zero thinking. But if the institution fails to differentiate that, the student is not the problem; your grading framework is. So, saying you want students to write the "best possible paper without using AI" rather than raising the ceiling and adopting the operating system of the next decade is nothing but administrative convenience.
Chris Hoofnagle@hoofnagle
Berkeley law has introduced a new, much stricter AI policy law.berkeley.edu/wp-content/upl…
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Fully automated recruitment and matchmaking. I agree to share my data with OpenAI, and companies recruiting sharing the role they want to fill. At the backend, you cross-check and if you see a certain % of match, notify both sides. Each side sets % depending on their desperation; the highest one is the filter. You do not get to filter job position or title or type as long as it is not legally required. Maybe location and salary expectation. Rest is up to the AI; it matches you. AI knows what we would be good at more than we do. Same with matchmaking.
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what problem do you most hope AI will solve in the future?
maybe we can help!
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Banning AI to protect cognitive skills is exactly like banning computers to protect the discipline of the typewriter. Computers encourage revision, while the typewriter punishes it. AI is just the next evolution and the opposite of what you think; its highest utility is to increase your cognitive workout. It becomes your sparring partner, stress-tests your logic, finds your flaws, and pushes you to continuously iterate further.
Yes, a student copying a first-draft AI output is doing zero thinking. But if the institution fails to differentiate that, the student is not the problem; your grading framework is.
So, saying you want students to write the "best possible paper without using AI" rather than raising the ceiling and adopting the operating system of the next decade is nothing but administrative convenience.
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@JohnnyNel_ @openclaw @Tailscale Haha honestly I’m just excited someone replied. Thank you! I built it for myself, paying $3 here, $4 there keeps adding up and I got tired of it. So here it is. Special thanks to @OpenAI 🤣
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@mrbese @openclaw @Tailscale local-first kills the telecom middleman completely... been telling founders the same thing, skip vendors and own your infrastructure
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No more paid voice-agent setups.
Introducing my first @openclaw skill: Call-My-Agent.
No Twilio.
No phone number.
Just a simple private voice line between you and your agent, running locally over @Tailscale
Small step for mankind, one giant leap for me.
xoxo,
@ClawHub: clawhub install call-my-agent
GitHub: github.com/mrbese/call-my…
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@KelseyTuoc @garrytan May I ask if thats the case with humans at night without being cancelled? Hypothetically.
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Are autonomous vehicles (self-driving cars) “less able to detect people of color”? That’s what I read in The Atlantic this weekend, in Xochitl Gonzalez’s “People Who Don’t Like People Are Making All of Our Decisions.”
It appears to be entirely false.
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Omer Bese retweetledi
🇹🇷 Türkiye quietly built one of the world’s fastest-growing missile arsenals in just 25 years.
From almost nothing to a major producer of advanced ballistic & cruise missiles, now rolling out long-range strike weapons like the new “Cenk.”
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@vasuman Come on, to the regular customer it looks like you baked a seamless custom signing system without any 3rd party, all on your own domain!!
And to the eye knows, this is the ULTIMATE flex that you're on top of the latest tech game! Just save the money. 🤗 You will eventually.
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In my experience there’s no better way to destroy your credibility than to use cheap knockoffs of popular software
If you send a client a Docusign link you at least appear to have a real business
If you send them something else they immediately just assume you’re broke
Also if your company has 10 people who need to send the maximum amount of documents, you’re probably making many millions
To the aspiring b2b founders reading this, don’t cheap out on any client facing part of your stack
Anyone telling you otherwise has not played this game seriously before
Nav Toor@heynavtoor
DocuSign Personal: $10 to $15 per month. DocuSign Standard: $25 to $45 per user per month. DocuSign Business Pro: $40 to $65 per user per month. A 10-person team on Business Pro pays $4,800 to $7,800 a year. To put signatures on PDFs. A team of 50 pays $24,000 to $39,000 a year. And there is a 100-envelopes-per-year cap on most plans. Send more contracts and you pay extra. Need SMS delivery? $0.40 per send. Need ID verification? $2.50 per attempt. Need premium support? $5,000 to $50,000 per year add-on. You are rationing digital signatures in 2026. DocuSign is a $10 billion company built entirely on this pricing model. Now meet DocuSeal. A free and open source alternative to DocuSign. Created in 2023 by a Ruby developer named Alex who was simply trying to sign one document and realised every solution online was overpriced or required a subscription. Three weeks later he had a working alternative. He pushed it to GitHub under the AGPL-3.0 license. Today it has 11,800+ stars and over 1,000 forks. Bootstrapped. No VCs. No paywalls. Here is what DocuSeal does: - Upload any PDF and turn it into a fillable, signable form - Drag and drop signature fields, dates, checkboxes, file uploads, and 13 field types - Send to multiple signers with custom signing order - Automated email reminders - Mobile signing on any device - PDF signature verification built in - Audit trail for every document - Bulk send and templates - Full API access - Self-host with one Docker command Here is what DocuSeal costs: Zero. Forever. Unlimited documents. Unlimited signers. Unlimited storage. DocuSign limits envelopes. DocuSeal doesn't. DocuSign charges per SMS. DocuSeal doesn't. DocuSign charges for ID checks. DocuSeal doesn't. DocuSign sees your contracts on their servers. DocuSeal doesn't. Here is the wildest part: The median DocuSign contract per Vendr is $17,250 per year. One Reddit thread has people saying "they want me to pay $4.80 per e-signature." Self-host DocuSeal on a $5 cloud server and a 50-person team can sign as many contracts as they want without paying a single dollar. Your contracts never leave your server. Your client lists. Your NDAs. Your employment agreements. None of it touches a third-party company. For individuals who only sign a few contracts a year, you save $180. For small teams of 10, you save up to $7,800 a year. For a 50-person company, you save up to $39,000 a year. Your documents. Your signatures. Your server. 100% Open Source. (Link in the comments)
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All aggregators had their payouts reduced to 60% this cycle. We will add another 20% deduction in the next cycle.
It became abundantly clear: flooding the timeline with 100 stolen reposts and clickbait everyday crowded-out real creators and hurt new author growth.
The next step is to assign a permanent deduction to habitual bait posters who use “🚨BREAKING”on every post.
X will never infringe on speech or reach—but we will not compensate for manipulation of the program or our users.
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Dom Lucre said he posted 100 times in a week.
Now that the money’s gone, so are the stolen clips every 15 minutes.
Funny how fast “content creators” disappear when the $ do.
Imagine if monetization disappeared entirely—this platform would look very different overnight.
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@andrewchen I would ditch Coachella and work all week in Austin from office @basepowerco @ZachBDell @JLopas . I created my position and wrote an articles what would i do if i got the job. Lets talk!
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noticing a trend of startups replacing standard resumes/interviews with week-long (or at least 3-day weekend) in-office trials. Makes sense in a world of AI-generated resumes and interview responses
Turns out the best signal for whether someone can do a job is watching them actually do the job. took us 100 years of HR to rediscover apprenticeships!!! 😂
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🚨 JUST IN: Apple caved!
the Anything app is back on the App Store
to celebrate vibe coding we are launching a $5k weekend hackathon
reply to get in + 20k credits
Anything@anything
BREAKING: Apple is scared of vibe coding they removed Anything from the App Store so we moved app building to iMessage good luck removing this one, Apple
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If you're interested in chatting with a partner from the a16z @speedrun team, my calendar is open this Thurs and Fri morning!
applications for the next batch open later this month, so come AMA 1:1
first come, first served. drop a comment + like and I'll DM you a calendly link
Troy Kirwin@tkexpress11
i'm opening my calendar for 15 min slots this Friday! a16z speedrun application opening is just weeks away - come AMA 1:1 first come, first served... drop a comment / like and I'll send you a link to schedule! (if there's space remaining)
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@garrytan Easter egg? But make it practical pls.. :) This is the future of recruiting, let me share my claude history and match me with open positions. @ycombinator
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Oh come on @satyanadella You can't teach your sugar baby how to work the legal pole then cry when another daddy starts making it rain. 🙄
Financial Times@FT
Microsoft weighs legal action over $50bn Amazon-OpenAI cloud deal ft.trib.al/6LZe39E
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