Munfy
2.3K posts


@topmass @cobalmain @munfy33 @the_no_mind @grok One suggestion, please stop taking it at night, it disturbs your sleep
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High dose vitamin D supplementation might be doing more harm than good.
Stephanie Seneff, MIT researcher:
Vitamin D is a signalling molecule, not a nutrient to megadose.
It mobilizes calcium — but doesn't control where calcium goes.
High dose vitamin D drives calcium into the arteries, leaching it from bones.
A 3-year study comparing 400 IU/day, 4,000 IU/day and 10,000 IU/day found the highest dose group had statistically significantly worse bone mineral density.
A 2006 study found that calcitriol supplementation (the active form of vitamin D) in young adults with kidney disease increased artery calcification — because calcitriol is taken up directly by cells in the artery wall.
Artery calcification is one of the strongest risk factors for cardiovascular disease.
An Indian study compared vitamin D supplementation to 20 minutes of daily sunlight in 100 men with severe deficiency.
Remarkably — the supplement group had a larger increase in serum vitamin D than the sunlight group.
Yet opposite effects on cholesterol:
Sunlight group — cholesterol dropped. Supplement group — cholesterol increased.
Why?
Sunlight and vitamin D supplements take completely different routes through your body.
Vitamin D supplements are fat-soluble. The liver has to synthesize cholesterol and release LDL particles just to transport them through the blood.
Sunlight stimulates cholesterol sulfate synthesis directly in the skin. The sulfate component makes the molecule water-soluble — transported freely in the blood without being packaged inside an LDL particle.
Because cholesterol sulfate is both water-soluble and fat-soluble, it can transfer from skin cell membranes to HDL particles or red blood cells and deliver cholesterol directly to tissues that need it.
No LDL carrier required.
When you get vitamin D from a supplement instead of the sun, you don't get the simultaneous increase in cholesterol sulfate.
The pill doesn't just fail to replicate sunlight.
It uses a completely different biological pathway.
Seneff: "Vitamin D wants to be subtle. Get out in the sun."
"People answer: oh yeah I know, vitamin D is important."
"No. Not vitamin D. The sun.”
Vitamin D is a proxy for sunlight exposure.
The proxy isn't the mechanism.
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@Burban0o @Dr_Biohacker Salt is essential, sure avoid high processed salt, but good healthy salt carries a ton of trace minerals. This guy is an idiot.
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@Dr_Biohacker So if you’re a high endurance athlete who has to consume extra sodium in the form of electrolytes how does that effect the heart?
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@Tybolt333 @ApexisPeptides @shawnmatthews03 @alexaaronlab When I first tried it I got some extreme fatigue, i could barely finish workouts, I added SS-31, and my cardio in the gym became insane, rarely get tired now and I recover super quick. SS-31 repairs your mitochondria so the mots can work correctly.
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@munfy33 @ApexisPeptides @shawnmatthews03 @alexaaronlab How did u figure it was mitochondria fatigue?
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@Tybolt333 @ApexisPeptides @shawnmatthews03 @alexaaronlab If you're on a weight loss path, just stick to Reta for now, add other things once you come off Reta.
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@Tybolt333 @ApexisPeptides @shawnmatthews03 @alexaaronlab I'd recommend SS-31 before trying MOTS-C but that's just my opinion.
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@ApexisPeptides @munfy33 @shawnmatthews03 @alexaaronlab Thx gonna check this stack out... am a fatty just hopped on trt
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@gregogallagher Me and my wife are both on Reta and we still have sex 3-4 a week.
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A lot of people whining about not feeling anything on Reta. Emotions suppressed. Not excited about anything…
Literally a non issue. 2.5mg tirzep and I feel fkn amazing. Life is full and great. Sex amazing
Give it a few weeks. And don’t listen to these hypo placebo responders
Low dose mostly just lowers food noise. Perhaps cheap dopamine hits less enticing.
But life, sex, real achievement and connection is unreal
ALSO.
Don’t starve yourself. Extreme deficit. Extreme exercise.
Balance is key
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@ApexisPeptides @shawnmatthews03 @alexaaronlab That's the exact stack I'm running and I'm absolutely loving it too.
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@JoeRoganRecaps When I went into ketosis I felt like absolute dog shit all day long and constantly fought dizzy waves.
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Joe Rogan spills the truth to comedian Joey Diaz that Zyns are the key to elite focus and why carbs are causing people to have massive brain fog and zero energy:
ROGAN: “I use my brain for a living. Zyns are great. They will make your brain function at a higher level.”
DIAZ: “I used to have an unbelievable memory, and now I can’t remember anything.”
ROGAN: “There’s a lot of people that think nootropics are BS, but I can feel a significant difference between taking them and not taking them.”
DIAZ: “Once I turned 60, I started to forget everything.”
ROGAN: “Ketogenic and carnivore diets are also great for giving you more mental clarity. It’s fact!”
DIAZ: “I need 8 hours of sleep now. 6.5 hours does nothing for me. I’ll throw an hour nap in there too at 2pm.”
ROGAN: “Sleep and creatine are so important too. Carbs also give you a ton of brain fog. My brain works way better if I’m just eating eggs and steak. 100%.”
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I'm a cardiologist. I need to talk to you about peptides — because the regulatory landscape just shifted dramatically, and most people are getting their information from the worst possible sources.
In February 2026, HHS Secretary Robert F. Kennedy Jr. announced that approximately 14 of the 19 peptides restricted under the FDA's Category 2 compounding list would be moved toward reclassification. The FDA's Pharmacy Compounding Advisory Committee is scheduled to formally review them on July 23-24 of this year.
If approved, peptides like BPC-157, TB-500, CJC-1295, Ipamorelin, GHK-Cu, KPV, and MOTS-C could become legally available through licensed compounding pharmacies with physician prescriptions for the first time since restrictions began.
This is a genuine turning point in regenerative medicine. And it's also the moment when misinformation could do the most damage — because demand has been exploding through gray-market channels for years, and people need both halves of the truth.
Here's the cardiologist's version. No hype. No bro-science. What the data actually shows and what you need to know.
The promise is real.
BPC-157 — a peptide derived from human gastric juice — has shown remarkable preclinical results in tissue repair, gut lining restoration, angiogenesis, and anti-inflammatory signaling. Animal models demonstrate accelerated healing of tendons, ligaments, muscles, and intestinal tissue. The anecdotal reports from physicians and patients are compelling — soft tissue injuries resolving faster, chronic gut issues improving, systemic recovery that's difficult to explain by placebo alone.
TB-500 — thymosin beta-4 — promotes cell migration, reduces inflammation, and supports cartilage and tendon repair. When stacked with BPC-157, the combination is the most discussed regenerative protocol in longevity medicine right now.
GHK-Cu — a copper peptide — shows anti-aging, antioxidant, and tissue-remodeling properties in preclinical studies. Skin, hair, and wound healing applications.
Ipamorelin and CJC-1295 — growth hormone secretagogues that stimulate natural GH pulses rather than flooding the system with exogenous hormone. Sleep quality, recovery, body composition, and muscle preservation are the reported benefits.
KPV — an anti-inflammatory peptide showing promise for gut inflammation, immune modulation, and conditions where standard anti-inflammatories have failed.
The preclinical data across these compounds is genuinely fascinating. The biology is elegant — these are signaling molecules that amplify your body's own repair mechanisms rather than introducing foreign pharmacology.
Now the half nobody wants to hear.
There are no large randomized controlled human trials for any of the recovery and longevity uses driving the current demand. Not one. The preclinical data is promising. The anecdotal evidence is compelling. But the gap between "animal models and case reports" and "proven safe and effective in humans at these doses for these indications" has not been bridged.
The gray market is a genuine hazard. Independent testing of research-grade peptides sold online has found that over 40% of samples from hundreds of vendors failed basic purity or dose standards. Wrong peptide content. Bacterial contamination. Heavy metals. Residual solvents from manufacturing. Endotoxins. When you buy a vial labeled "for research use only" from an unregulated website, you have no guarantee that what's inside matches what's on the label.
Kennedy himself acknowledged this directly — the Category 2 restrictions didn't eliminate demand. They pushed patients toward unregulated sources with no pharmaceutical oversight. The reclassification is partly an attempt to bring these compounds back under quality-controlled compounding with physician supervision.
Side effects are real and underreported. Most peptide content online shows the upside only. In practice: nausea, GI disruption, injection-site reactions, headaches, water retention, joint pain flares, mood changes, and hormonal disruption have all been reported. BPC-157's promotion of angiogenesis — new blood vessel formation — is a double-edged mechanism. It accelerates healing. It could also theoretically feed an existing tumor. Anyone with a cancer history should approach BPC-157 with extreme caution. Growth hormone secretagogues can affect insulin sensitivity and blood sugar regulation — directly relevant to the metabolic health I monitor as a cardiologist.
Reclassification does not mean FDA approval. Even if these peptides move to Category 1, they remain unapproved drugs available only through licensed compounding pharmacies under physician supervision. This is not an invitation to self-dose from internet vendors. The regulatory shift creates a legal pathway for quality-controlled access. It does not validate every protocol circulating on Reddit.
What I'd tell my own patients right now:
Wait for the July PCAC review before starting anything new. The regulatory clarity coming in six weeks could change what's legally available and at what quality standard.
If you're already using peptides, demand certificates of analysis with batch-specific mass spectrometry data and endotoxin testing from your source. If your vendor can't provide this, you're injecting an unknown substance.
Never start a peptide protocol without physician oversight and baseline bloodwork — hormones, liver function, kidney function, fasting insulin, inflammatory markers. Monitor throughout.
If you have any history of cancer, approach angiogenesis-promoting peptides like BPC-157 with extreme caution and discuss the theoretical risk explicitly with your oncologist.
Cycle intelligently. These are not meant for indefinite daily use. The biological signaling works best in targeted courses, not chronic administration.
And never let peptides replace the foundation: sleep 7-9 hours, resistance training, real food, stress management, and the metabolic optimization I write about every week on this platform. Peptides amplify a healthy system. They do not rescue a broken one.
The peptide revolution is real. The biology is fascinating. The regulatory landscape is finally catching up to the demand.
But the difference between a clinical tool and an unregulated gamble is physician supervision, pharmaceutical-grade sourcing, and honest assessment of what the evidence does and doesn't yet support.
Both halves. As always.
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@BigDadEnergyX Cardio is a cake walk on it. I could lift heavy for an hour and then do stairs for another hour and I'd barely be breathing heavy, I'd get some crazy highs during workouts as well, insulin resistance also really improved.
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@danielobvt @ClintFiore I got severe shortness of breath the two times I took Ezetimibe.
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@ClintFiore Not a peptide but I, it my total not a doctor opinion, would look at Ezetimibe to stomp that apob/cholesterol down. Cheap, no sides.
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OK joking aside... these have been my long term side effects from 16 months on the peptides.
Just got bloodwork back and body scan done yesterday.
Not perfect. Not done. But way better than I was.

SMB Attorney@SMB_Attorney
I really hope all these peptides and GLPs don’t have long term side effects or we’re in big trouble.
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@ZaZa813767 @AdamLehrerSP @Madnox01 @KChimaev @SStricklandMMA His legs buckled in the second. Go back and watch the fight.
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@Briggsly @EricLDaugh Nothing has a 100% safety. That why in every pharmaceutical commercial it lists the 50 side effects.
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@EricLDaugh Cardiotoxicity of ibogaine is the limiting factor. Medicines need efficacy AND safety.
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🚨 WOW! Joe Rogan reveals President Trump IMMEDIATELY offered him FDA approval for a psychedelic treatment in a text chain
Because the data was SO CONVINCING and STUNNING
"I wanna tell everybody how this happened. I send President Trump some information."
"With one dose of Ibogaine, more than 80% of people are free of that addiction. With two doses, it's more than 90%. I sent him that information."
"The text message came back, sounds great. Do you want FDA approval? Let's do it. It was literally that quick!"
"For 56 years, we've lived under those terrible conditions. We're free of that now."
"We're free of that now, thanks to all these people that you see next to me, and thanks to President Trump!" — @joerogan
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@DrJesseMorse I smoked weed for almost 15 years of my life all day everyday, my wife got pregnant with my first 3 children when smoked heavily. They're all very healthy children. My wife is now pregnant with out 4th, ive quit smoking for 3 years now, guess we will see if this one is healthier.
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Trying to conceive and smoking weed regularly?
I wouldn’t recommend it…
Andrew D. Huberman, Ph.D.@hubermanlab
Cannabis is detrimental to sperm: even if they can fertilize, there can be DNA damage. Many miscarriages and (in the case of IVF) “day 3 crashes” which is when paternal DNA normally kicks in, are cannabis related. Dr Natalie Crawford on the Huberman Lab podcast out now.
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@y2k192 @TheShreddington White coat syndrome. It's actually a real thing.
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@TheShreddington Ya, it’s good.. it’s just something about walking in that office..
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@topmass @the_no_mind @grok 148 is great, I take around 10,000 iu's as well along with k2 and magnesium and my levels are still only at low 50s from my bloodwork last week, I could honestly take more if I wanted.
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@darkwing751 @ProjectConstitu It's not an explosion, it literally shoots a bullet...
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@ProjectConstitu Explosion would rip his shirt up and his body would be so mangled up if a explosion happened under his shirt. What you are seeing is force of the bullet hitting his body. Blowing him backwards
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🚨 MYSTERY SOLVED: What Really Pulled the Fabric Over His Shoulder. WE NOW HAVE VISUAL PROOF😳
Massive shoutout to Jon Bray for obsessively tracking this down. This new 4K close-up of Charlie’s shirt changes EVERYTHING.
We have said for months this was NOT a gunshot. It was an INTERNAL EXPLOSION detonated under his clothing. And now, the evidence is undeniable.
You can clearly see the explosive path: The blast starts at the left-side mic pack and detonates UNDER the fabric. The object is propelled UPward, creating that signature "pinched" effect on the shirt as it races towards his neck. Then, in the ultimate confirmation, you see the object fall back down under the shirt, tracking diagonally across his chest before coming to rest on the bottom right.
If you watch this clip frame-by-frame, you can literally follow the path of the PETN explosive device propelled by the blast:
1️⃣ It starts at the mic receiver pack on his left belt.
2️⃣ The explosive force drives the object UP under his shirt.
3️⃣ You see the shirt get pinched and yanked violently over his left shoulder as the object is propelled toward the neck wound.
4️⃣ The object then falls, traveling diagonally under the fabric.
5️⃣ You can see the distinct bulge where it tracks all the way down to the lower-right side of his shirt.
It’s over. The 30.06 gunshot narrative is dead. Tyler Robinson is EXONERATED. The real monsters are EXPOSED. 👁️🕵️♂️
This directly implicates the highest levels OF GOV'T. This is the kind of embedded-tech warfare we saw during the pager attacks. Only a state-level intelligence operation—specifically our favorite ally—working with Charlie's own compromised team are capable of this precision hit.
Watch the object move. Stop pretending you don't see it. 👇🍿
Massive Shoutout to @jonaaronbray FOLLOW Him!
Project Constitution@ProjectConstitu
🚨BOMBSHELL: Fragment Foun fIn Charlie's Neck Doesn't Match Gun Found At The Scene x.com/i/broadcasts/1…
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