D

@AbudBakri Clonidine patch 0.1 mg. Maybe magnesium glycinate

Why not use an ARB like losartan, which will be cheaper than any OTC supplement, cardioprotective (especially if using/abusing androgens), and most importantly…efficacious? In my mind there are no supps or meds. There are only exogenous compounds with different degrees of risk

@NeuroAI_Nexus @AbudBakri

Aging disrupts sympathetic innervation of the thymus cell.com/cell-reports/f… The thymus, essential for lifelong T cell development, is tightly regulated by the sympathetic nervous system. Aging causes degeneration of sympathetic axons: loss of nerve fibers, reduced synapses, and disrupted neurovascular structure leading to impaired thymic function. Sympathomimetic treatment can partially restore this decline, revealing a key neuro-immune axis in aging. #Neuro_Immunology #Neuro_Aging #Thymus #Longevity #Aging

@PaulReynoldsPhD To what extent does 250F temperature smoked meat affect glycation load?

Cooking method matters more than most people think when it comes to dietary AGEs. Boiling and steaming generate far fewer AGEs than excessive grilling, frying, or roasting at high heat — even with the same food. The Maillard reaction that creates that delicious browning? That's glycation happening to your food before you even eat it.

@nothingmark @hasantoxr @mario_gug techpolicy.press/how-to-apply-t…

@ProfFerguson @hasantoxr @mario_gug Do you have any podcasts or lectures? Having trouble finding talks

@hasantoxr @mario_gug

Google has a recording of every search you've ever made. Every place you've ever been. Every YouTube video you've ever watched. Go to myactivity.google.com right now. You'll find searches from 2015. Voice recordings. GPS coordinates. All stored. All linked to your name. Here's how to see it and delete it:

@jwalkermobile @FoodPleaser Excellent searing

@FoodPleaser Love Scallops!

Lemon Garlic Butter Scallops 💛

@olgatuleninova Excellent work

David Lenz (American, b.1962) "Brocken Spectre and Glory: Portrait of Temple Grandin," 2022 Oil on canvas 44 x 58 in National Portrait Gallery, Smithsonian Institution, Washington, DC

@Mollyploofkins @AVARY

Hegseth quotes fake Pulp Fiction Bible verse during Pentagon sermon

@PaulRieckhoff @RealTimers @billmaher @indy_americans @IndyVetsAmerica Thank you for discussing chickenhawks

And…I recorded this right after we finished on @RealTimers with @billmaher. Whew. Let me know what you think after you see it. And if you’re new here, welcome! Please check out @indy_americans and @IndyVetsAmerica for more. America wants fighters. And we’ve got em. Join the movement. And let’s fight back together.🚨🇺🇸 #RealTime #RTOverTime

@amtrusova Beautiful work

acrylic, canvas 40 * 30 cm «Forget-me-not» 2019.

@pietrobaudin What pen is this?

san_arrts are a GOD of pen and ink 🙌

@TarrantIsRed @ifixhearts Excellent

@ifixhearts My triglycerides are 49, HDL is 71. I think that’s really good, right?

@ifixhearts @HemmenJeff

@GarryPNolan @TkMe2UrLeader11 Please have a podcast with @drmichaellevin . Two geniuses in their fields

It could also be that the rare-earth peaks are misassigned diatomic or triatomic ions. These are cases where atoms combine after vaporization, sputtering, or ion formation and then appear at the same nominal mass-to-charge ratio as heavier elemental ions. For example, a silicon dimer composed of two 28Si atoms has an exact mass of 55.9539 u (28Si + 28Si = 27.9769 + 27.9769 = 55.9538 u; more precisely 55.9539 u depending on rounding), so in the singly charged state it appears at m/z 55.9539. That would resemble Iron (56); it is much closer to ions near nominal mass 56. By comparison, 54Fe is 53.9396 u, 56Fe is 55.9349 u, and 56FeH is 56.9427 u. A Si dimer containing one 28Si and one 29Si would appear at 56.9508 u, and 29Si-29Si at 57.9477 u. Thus, dimers can overlap heavier elemental peaks if the instrument lacks sufficient mass resolving power to separate differences at the third or fourth decimal place. Charge state also shifts the observed m/z. A doubly charged ion appears at half its mass-to-charge value. Thus, monatomic 28Si2+ appears at m/z 13.9885, not at 28. Likewise, 28Si22+ appears at m/z 27.9769. This is why multiply-charged ions can be mistaken for lighter singly charged species if the charge state is not recognized. For reference, 14N+ appears at 14.0031, 28Si2+ at 13.9885, and 28Si+ at 27.9769. For instance, Al272+ might be mistaken for iron 54. At nominal mass 54, the main elemental isotopes are: ^54Fe = 53.9396 ^54Cr = 53.9389 ^54Xe = 53.9396 Other possible assignments near m/z 54: ^27Al2^+ = 53.9631 One way to look for this is decimal accuracy. The other is ratios of the expected isotope distribution. If the distribution is off, it doesn't necessarily mean the isotope ratios are "unearthly" —you have to double-check for diatomic or doubly charged ions. There are many cross-checks needed. So, accuracy to the 2nd, or even 4th, decimal place is key. Since the masses are not included in the report, one must be careful, and the data must include nominal controls. There are ways to correct this, especially in SIMS, including isotope-pattern checks, charge-state analysis, expected molecular-ion chemistry, and use of instruments with sufficient resolving power to distinguish exact masses to the third or fourth decimal place. Also, many "pure" materials contain various other elements. Not opining on the conclusions, just pointing out there are always caveats to be considered.

The Buga Sphere looks to be a terrestrial cast aluminum alloy from the 3xx.x series (Al-Si-Cu) or 2xx.x series (Al-Cu), specifically a recycled or modified version with mischmetal (rare-earth) micro-additions.

@PaulReynoldsPhD @garytaubes @michaelpollan @MichaelMossC

Heart disease kills 9 million people annually. We blame cholesterol. We should be blaming sugar. Every time blood glucose spikes, glucose molecules bind to proteins and lipids through a process called glycation — hardening arteries, stiffening tissue, and igniting chronic inflammation that quietly destroys the cardiovascular system. The heart doesn't fail because of fat. It fails because of a metabolic environment we created — one meal at a time. Fix the glucose. Fix the fire. #MetabolicHealth #InsulinResistance #Inflammation #Glycation #Longevity

@mcuban Giving a fancy, unreliable algorithm root access to your files and finances is a recipe for disaster. You will eventually be hacked or spend an unexpected fortune on tokens. Use a sandbox, don’t automate your life away. Be cautious

Have you ever added a router or access point to a network ? The second you turn it on, it starts getting lit up. Hopefully uou change the PW and configure it properly This is exactly how agents will try to sell you things. The minute you light up an agent and the .md file is available to be read, it is going to be lit up non stop. Agents trying to take advantage of EVERYTHING. Agents are going to be easy to set up, hard for individuals to use correctly in a Wild Wild West Agent world. Thoughts ?

@ScottAppliedSci SGLT2 for $50/month is vastly superior in every way. Statins substantially increase risk of diabetes and they’re expensive @mcuban

Last comment on statins for a while. It's peculiar how one of the safest drugs we have for one of the most common deadly conditions arouses such emotion and vitriol? I used to be one of the hecklers, too. What fixed me was reading primary sources, not grifters selling something.

@MatthewPHoh Please do a podcast with @EdwardGLuce or @MkBlyth

This reads to me like the regional states see the continuation of the regional war, the near certainty of economic recession (maybe eventually depression), new waves of refugees, and an angering of their population as better for their interests than angering the US. The interests of these states, all but one autocratic, is in preservation of its rulers, their privilege and the continued aid and support of the US. They often see only in the short term and mistake agreement and obeisance of the US as partnership. To them, continuance of the war brings risk, but disagreement and rejection of the US brings certain damage and likely demise. For most, they individually are too scared to make any decisions that would affect a relationship with the US, getting close to a century long, that ensures their own hold on power. Together, there is no trust among them to break from the American Empire as a group. It’s hard for me to understand their shortsightedness and reckless assumption of the risk of this war other than that. If you have an explanation to help me understand, please share.

@MatthewPHoh @HuntClancy @ShawnRyanShow please have @MatthewPHoh on your show. Tremendous integrity and courage

@HuntClancy Thanks Matt

no one fucking resigned over the war in Afghanistan during that entire 19 year clusterfuck except for a principled state department official who’d been a marine in Iraq @MatthewPHoh and he’s my friend and the Obama administration came after him with every dirty trick in the book