parul

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parul

@parulia

partner + builder @645ventures | investing in AI agents, dev tools, and infrastructure | previously @initialized @fcollective @mit | here to help founders win

San Francisco, CA Katılım Nisan 2007
3.5K Takip Edilen11.6K Takipçiler
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Packy McCormick
Packy McCormick@packyM·
Demis gets $2.1B to solve all disease Varda inks United deal to explore Space Drugs ANOTHER blow for pancreatic cancer Cerebras + Fervo IPOs pop, Figma roars back Cowboy Space Corp hops in the saddle + Science Breakthroughs, vacuum, v3, magic What a week for the optimists.
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dylan matthews 🔸
dylan matthews 🔸@dylanmatt·
Very excited to launch a project I've been helping out with the last couple months.* The Center for Shared AI Prosperity is an attempt by an, other than me, very impressive team (so far including @davidshor, @katz_morris, @StefFeldman, @maidinoff, Lindsay Lamont, Jesse Stinebring, @joshhendler, @goldman, and Lilah Penner Brown) to force DC policy elites to take the impending economic impacts of advanced AI more seriously. We do not think this is a normal economic shock, though we are deeply uncertain about what kind of economic shock it will be. We could be left with a world of extreme power and wealth concentration, increasing political instability arising from that growing inequality, and deep questions about how to fund governments that have for a century-plus relied on income and payroll taxes. Our main purpose as an organization is to surface tractable ideas to reform and grow the safety net to meet the moment; to restructure the labor market so workers are still valued and fairly paid; to remake the tax code so that the gains from AI are shared widely; and to experiment with ways of giving average Americans concrete shares in the AI surplus. To that end, we're running a Request for Ideas, and we're offering $3,000 for the best proposals. Top ideas will get rigorous polling from Blue Rose Research to see how Americans feel about them. We are trying to solicit submissions from a wide pool, and purposefully don't want to just ask the usual think tanks, economists, academics, etc. (Though we want them too!) If you have ideas that you think could be useful, please don't hesitate to apply. Feel free to reach out to me if you have any questions about the program. Read more here: csaip.org *Obligatory disclaimer: I'm doing this on my personal time, not in my capacity at Coefficient Giving. Nothing I or CSAIP say necessarily reflects CG's views.
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tmuxvim
tmuxvim@tmuxvim·
I put a prompt injection into my LinkedIn bio and recruiters are messaging me in Old English and calling me Lord.
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Arvind Jain
Arvind Jain@jainarvind·
The center of gravity is shifting from the model layer to the operating layer around the model. But inside real companies, the primary bottleneck is rarely raw model capability. It’s getting AI to operate reliably across fragmented data environments, inconsistent processes, permission structures, legacy systems, and workflows shaped as much by tacit knowledge as formal policy. The competitive advantage is the context and operating layer that lets companies orchestrate, govern, and swap models without losing value.
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Ben Thomas
Ben Thomas@Ben_Thomas_o7·
Great podcast presenting important economic theory clearly. You could send this to your grandma! Derek & Alex cover: - Lump of labor fallacy: tech frees humans up to do new jobs - Jevon's paradox: structurally lower prices often increase quantity demanded -> more jobs (demand is often elastic) - O-ring model: many jobs need high certainty on all tasks; automating % of tasks doesn't automate the job - Human privilege: handmade goods & services are a luxury good; you buy more not less as income increases I would add: - Liability: jobs are about delegating responsibility/blame, not just tasks. and the legal system needs liability somewhere - Relative status seeking: humans care about their relative standard of living >> their absolute standard of living (for better & for worse). just look to academia to see competition, scarcity, and work created in an environment of normative abundance! - New goods: there is so much more work to do. feed & educate everyone, explore the oceans, inhabit space, terraform moons! energy, intelligence, and materials too cheap to meter. there is a lot to do before an AK economy
Derek Thompson@DKThomp

New pod: THE SMARTEST CASE AGAINST THE AI JOBS APOCALYPSE AI is the first technology that seems to automate the same cognitive sectors that absorbed work during previous waves of automation. For that reason, many people worry that it will destroy tens of millions of jobs imminently. But after I review the evidence showing that AI is not clearly destroying work today—and might even be stimulating demand for certain tech jobs— I brought on the great @alexolegimas to talk about the best reasons to doubt the doomsday narrative. We talk about all sorts of economic principles—lump of labor fallacy, income elasticity, Jevon's Paradox—but maybe his most interesting point is about the nature of desire and status. Desire is insatiable, and technology will never solve for status. Even in a world where AI can automate many tasks, status might go up rather than down or flat. And status motivates a lot of economic activity. So even in a world where AGI is very good at 99% of existing tasks is still a world where people will want to send their money to things that are perceived as "scarce" and "status-enhancing." You can create a lot of jobs on this basis alone. You could argue that this is how economic transformations have always worked. Our economy is a rough register of human desires. And in a world where artificial intelligence automates some tasks, it might not destroy work so much as it moves dollars and labor toward new desires in new sectors of the economy. The pet care economy wasn't really a thing in 1800. Now it's a >$100 billion business, made possible by the fact that a richer country moved dollars and workers from corn farms to bespoke poodle manicure spas. It is easy to imagine that AI could automate many tasks and even some jobs. What's harder to imagine is that we'll be permanently stuck in an disequilibrium where people with disposable income aren't trying to satisfy their desires and burnish their status. And in a world where AI is abundant, the question we should be asking about the future of work is: What will be scarce? What will be kind of jobs will be produced as desire and status shift, once again? open.spotify.com/episode/74OPgO…

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Nicole Quinn
Nicole Quinn@Nik_Quinn·
No need for any more cold emails!! I am not an investor (so no biases) but am a huge fan of metal.so. It shows founders who's actively investing in your space, at your stage and who is the best to speak to. They have ~170k investors in their database and also map the warm intro path (maybe most important!). This is how fundraising should work.
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Bilal Zuberi
Bilal Zuberi@bznotes·
I remind myself of this quite often.
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Gokul Rajaram
Gokul Rajaram@gokulr·
HEADLESS The reason more “dashboard” software companies will push to become headless stores (that is, become “pipes” companies) is for two reasons: (A) one of the most durable opportunities in software is to become the singular data store for all structured or unstructured context for a certain domain or function (or heck, for the entire organization). (B) once a function or org embraces you as the data store, you price based on compute and storage, and beautifully compound and grow as the org context inevitably explodes over time, the way other compute/storage businesses like Databricks and Datadog have durably and steadily compounded over time. Now, of course, the challenge is that as soon as you open up to 3rd party agents, some of these agents, being venture funded companies themselves and run by ambitious entrepreneurs, will try to suck all the context out of you, reduce you to a CRUD database, and ultimately offer a version of you to their customer for free, bundled with their agents. Meanwhile, you will likely offer your own bundled free or low priced agents as alternatives to the most commonly used third party agents. This war between headless context stores and agentic workflow startups is just starting. Will be interesting to see who can commoditize their complement first.
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Lenny Rachitsky
Lenny Rachitsky@lennysan·
Love this reminder from @tfadell "Makers often focus on the shiny object—the product they’re building—and forget about the rest of the journey until they’re almost ready to deliver it to the customer. But customers see it all, experience it all. They’re the ones taking the journey, step-by-step."
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ian
ian@IanRountree·
I went all-in on hard-tech in 2018 but when Jennifer started @ScribeHow I had to make an exception. She didn't need the money at the time (mid-2020) so declined my initial offer. So I signed an uncapped SAFE and sent her a DocuSign. She said, "Well if you're going to make it that easy..." I got some pushback from a couple LPs investing in a software startup on those terms, understandably, but I told them they'd just have to trust me on this one. $100M ARR later it is––somewhat awkwardly––the highest multiple in that respective fund and not stopping anytime soon! Thank you for making me look smart, Jennifer! I would've been in hot water otherwise 😅
Jennifer Smith@scribeceo

@ScribeHow just crossed $100M ARR. Today, our 90,000 enterprise customers include nearly half the Fortune 500. I shared this news with @jonfortt on @CNBC earlier today, but I still vividly remember our first deal for $7K! I’m proud of our team and grateful for our customers. The reality is, we’re just in the first inning. Most companies are still very far from the AI transformation they imagined. A lot of AI usage at work is still for personal productivity: it’s not locked into where and how an org creates its value. The models aren’t the problem. It’s that they aren’t being taught enough about the business. AI has a context problem. AI gets dropped into companies
without knowing HOW work actually gets done. That’s thousands of workflows AI can’t see. Dozens of decisions it can’t trace or recreate. AI doesn’t understand your org at all.
 Missing workflow context is now an existential problem for the enterprise. Without context, AI can’t function. It just delivers generic output, or confidently gets things wrong. For AI to actually work inside enterprises, something fundamental has to change. That’s why we’re witnessing a new layer of the enterprise stack emerge. To pull ahead companies need to map their context layer, making it legible to both humans and agents. Here's my full thinking on workflow context and why it’s the most urgent need in enterprise AI: scribe.com/library/100-mi…

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Elizabeth Yin 💛
Elizabeth Yin 💛@dunkhippo33·
Almost all of my serial founders have figured out how to get customers super quickly, even sometimes pre-product. They learned from their first business that that was the primary problem.
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Daniel Pink
Daniel Pink@DanielPink·
Every AI pitch promises the same thing: Do more in less time. Finally get to the important stuff. Work less. New research from Berkeley followed real workers for 8 months. That's not what happened. 👇
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Mgoes (bio/acc 🤖💉)
Mgoes (bio/acc 🤖💉)@m_goes_distance·
biotech will do more for humanity in the next 18 months than the last 50 years here is what the next 12-18 months carry: 1. aging becomes reversible - Life Biosciences reports results from the first ever human epigenetic reprogramming trial by end of 2026. if it works the entire category reprices overnight 2. your genome becomes your medical record-consumer grade sequencing is already at $1,100. by 2027 it is a standard intake form 3. personalized gene therapies become real - baby KJ proved a custom CRISPR therapy can be built for one person in 6 months. his doctors are now building the FDA pathway to do it for everyone 4. peptides go fully mainstream - 14 of 19 banned compounds are coming back to legal compounding. the grey market becomes a regulated industry with actual quality standards 5. psychedelics become first line treatment - Compass Pathways is weeks from the first ever FDA approval of a psychedelic drug. depression and PTSD treatment just changed permanently 6. AI designs drugs that work better than anything a human team has ever produced- Isomorphic Labs is pushing AI-designed molecules into human trials right now. results expected this year 7. BCIs move from medical to performance - Merge Labs, Neuralink, Synchron all pointed at the same target. the first healthy person gets an implant for cognitive enhancement and the waitlist forms immediately after bio/acc
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Sheel Mohnot
Sheel Mohnot@pitdesi·
In case you were wondering where we're at in the cycle, I just heard about a seed round where the founder is selling secondary
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Nir Golan
Nir Golan@lawheroezV2·
“According to Anthropic, "Legal is now the #1 power-user job function in Claude Cowork." 🔥🤯
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Paul Millerd
Paul Millerd@p_millerd·
consulting is a great and valuable industry. always has been every company that gets big enough eventually realizes the constraint is implementation / adoption of their products or services. underneath that, human resistance to change every company from GE to IBM to you name it has eventually developed their own internal consulting teams in addition to relying on external consultants who quickly understand new market opportunities I think we are seeing these rapid and large scale moves into consulting (or call it FDE whatever you feel like) because of a few things: 1. downside risk on the capital deployed is enormous. these bets, while large are tiny % compared to total capex across the biggest players 2. The speed of adoption of the models is rapid, but the speed of turning tokens into dollars for businesses will likely not be as rapid. The success of the model companies relies on turning tokens into dollars (Either in opex savings or increased profits) as fast as possible. Consulting helps activate more efficient capital/labor/token allocation across enterprises consulting has been underrated by tech for years. it is a highly market efficient industry and the best firms adapt much much faster than traditional companies I happened to be working at McKinsey in 2008 during the global financial crisis. from september 2008 to december 2008, the firm had pivoted almost every global practice to responding to the practive. endless new service lines were created, new capabilities were developed. many also flopped or didnt go anywhere but large-scale change efforts became a much bigger business over the next few years, the big consulting firms will continue to thrive - mck, bain, bcg but also accenture, and other IT oriented firms. They have the labor at scale who understand change and implementation. Most people's model of consulting is based on a caricature of a 1980s strategy case, with a report at the end of the project handed to the board. that is no longer the case. McKinsey is a full service firm with a digital arm, an implementation arm, analytics and IT solutions, etc. the scale of these firms continues to astound me. They will only get bigger. The core "service" they offer is a 3-5 person team and since each 3-5 person team can work on different things and iterate on each project, these firms are highly adaptable. But in a growing market there is room for more, and who benefits? well, look at the investors here: "Investors also include leading consulting and systems integration firms, including Bain & Company, Capgemini, and McKinsey & Company." long consulting
OpenAI@OpenAI

Today we’re launching the OpenAI Deployment Company to help businesses build and deploy AI. It's majority-owned and controlled by OpenAI. It brings together 19 leading investment firms, consultancies, and system integrators to help organizations deploy frontier AI to production for business impact. openai.com/index/openai-l…

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Mario Gabriele 🦊
Mario Gabriele 🦊@mariogabriele·
Investor Cyan Banister (@cyantist) recalls the bee die-off headlines: bees are dying, humanity is doomed, and we will need robot bees to survive. She explains that the solution came from a mycologist, who noticed unusual bee behavior during a walk through a forest. His observations led him to develop a treatment for the declining bee population. Her larger point is that AI makes this the norm. When the knowledge gap between disciplines closes from decades to hours, the fluid dynamics researcher stumbles into a physics breakthrough; the ecologist becomes the apiarist.  The polymaths win: not because they know everything, but because they have the tools to connect what specialists cannot. @thegeneralistco
Mario Gabriele 🦊@mariogabriele

Investor Cyan Banister (@cyantist) has backed SpaceX, Uber, Niantic, and Flock Safety. A majority of those investments did not emerge from a formal meeting. Uber traced back to a conviction that the taxi medallion system was a racket. Niantic grew out of watching friends charter helicopters for an obscure geolocation game. Flock Safety materialized from reading the public WiFi list at a Four Seasons cafe. Her method is not a framework. It is attention: a lifelong habit of noticing bottlenecks, tracking human obsessions, and poking at reality until it reveals something others missed. In this conversation, she covers: • Why the taxi medallion system was the real Uber insight •How she found a $7 billion company on a public wifi list • The Biz, Tizz, and Rizz framework for identifying legendary founders • Why the age of the polymath is arriving faster than most people expect • How brain-computer interfaces are surfacing thoughts from two weeks prior • Why she believes vibe manufacturing will mint the largest wave of new millionaires in a generation The signals she is reading now are worth understanding. @thegeneralistco Thank you to the partners who make this possible @dottechdomains: An identity for builders at their core: go.tech/thegeneralistnl @brexHQ: The intelligent finance platform: brex.com/mario @withpersona: Trusted identity verification for any use case: withpersona.com/generalist (00:00) Intro (03:51) Never playing the game you appear to be playing (07:18) Practicing childlike wonder as a daily discipline (10:08) Questioning belief after her stroke (13:30) Cyan’s metaphysical experiments (23:24) Non-local consciousness and creativity (27:22) Investing with extreme openness to signals (29:05) The importance of timing in investing (32:26) Meeting Travis Kalanick (34:19) Finding Flock Safety through a chance encounter (38:23) The summer of Pokémon Go (what worked and what didn’t) (39:55) Human nature and what makes something "stick" (42:15) Brain-computer interfaces and AI’s accelerating effect (52:53) “Biz, Tiz, Riz:” her framework for evaluating founders (59:20) Why Cyan lives in a retirement community part-time (1:03:50) A unique way of finding books that speak to you (1:08:44) Final meditations

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