Patrick Griffin

Infinite Epigenetics & True Diagnostics acquire @sinclairfriends lab spin-out, Tally, giving them access to DNAme IP to help bring down costs & accelerate epigenetics-informed health care Congrats to @L_Catterton, @melanie_goldey, @patrick_griffN, @gladyshev_lab & the entire team! 👏

It takes two (transcription factors) to tango Transcription factor collaboration enables precise T cell state engineering tinyurl.com/tcelltfs Excited to share our preprint with @JD_Buenrostro, @cgersbach, and an incredible team of collaborators as part of @IGVFConsortium 🧵

Excited to share my postdoc work with @JD_Buenrostro now out in @Nature! "Epigenetic memory of colitis promotes tumour growth" nature.com/articles/s4158… We wanted to understand how transient inflammation can create a long-lived increase in cancer risk, even after full recovery 🧵

First test of partial epigenetic reprogramming to reverse aging for two eye conditions (glaucoma and NAION) gets FDA go ahead @lifebiosciences Based on 2020 @Nature paper pubmed.ncbi.nlm.nih.gov/33268865/ endpoints.news/exclusive-fda-…

Huge thanks to all co-authors and the inimitable @JD_Buenrostro for supporting this new direction - I got to think about evolution, engineering, chromatin biophysics, and modeling during the course of this project. For more, check out the preprint: biorxiv.org/content/10.110…

Excited to share a short article I wrote describing: Slide-tags - which enables spatial single-nucleus sequencing, allowing us to dive deeper into the complexity of tissue organization. Grateful for the amazing team and support from @insitubiology and @macosko! #ToolsOfTheTrade

The latest LLLM (large language of life) foundation model, with state-of-the art chronological age estimation, prediction of outcomes, and performance across different datasets and conditions

Introducing IN SITU GENOME SEQUENCING, a new technology to resolve DNA sequence🧬 and structure🔬 A team effort with @Andrew_C_Payne, @PaulReginato, @eboyden3, @JD_Buenrostro, and Fei Chen science.sciencemag.org/content/early/… This is how it works: (1/8)

Thrilled to see our ExIGS tool featured! A true testament to the power of collaboration. Huge congrats to the team for their hard work! 🧬@ajaylabade31 @z_chiang @CarolineComenho nature.com/articles/d4158…

Grades of DNA methylation as the basis of epigenetic cell memory... must-read. biorxiv.org/content/10.110…

T cells become exhausted and fail to control tumors in cancer patients. What if we could replicate T cell exhaustion in vitro and uncover the gene regulatory network driving exhaustion, enabling immuno-oncology drug discovery? With AstraZeneca, the Buenrostro lab addresses this gap (biorxiv.org/content/10.110…):

Study Proposes Framework to Standardize Biomarkers of Aging and Accelerate Clinical Use @jpoganik Read more: buff.ly/3OMHMBo

We are recruiting postdoctoral fellows in neurobiology and development to complement our group specializing in genomic technologies, epigenetics and machine learning. projects are very well funded and we are interested in co-mentorship. Please DM if interested in hearing more!

Our latest paper is out - a new method called "TIME-Seq" to measure biological age for just a few dollars. Great work Patrick Griffin! @NatureAging Free download rdcu.be/dvDfc

@ThomasJGriffin0 @BlackHarePress Huge congrats brother! 💪

First contract of the year signed 😊 My flash story "Christmas Mourn" will appear on the @BlackHarePress Patreon and in their Year Six anthology!

Can we reverse aging? 7 yrs ago, Ocampo et al. showed that partial reprogramming can ameliorate aging hallmarks. But, OSKM induction has safety limitations & no new factors have emerged since. Here, biorxiv.org/content/10.110… we used 🧬 screens to find new rejuvenation factors🧵1/8

Delving into our newly released result, a thread:

Can we shield the epigenome from age-related changes, much like how SIRT6 defends the genome? Using a CRISPRi screening approach, @XiaoTianPhD seeks to identify genes involved in maintaining epigenome stability. His new lab @sbpdiscovery is recruiting for various roles!

Xiao is one of the most productive and kindest scientists I have ever met! Amazing opportunity

Congratulations HSCRB Associate Professor @jd_buenrostro for being been named a 2023 #MacFellow! @macfound #searchresults" target="_blank" rel="nofollow noopener">macfound.org/fellows/class-…