ratcortex

Abdominal Movement Flushes Neural Waste The brain is far more mechanically integrated with the rest of the body than scientists previously realized. In a study, researchers revealed a “hydraulic pump” mechanism that links physical activity to brain health. When you contract your abdominal muscles, even during a light movement like taking a step, you compress blood vessels that push fluid into the spinal cavity. This pressure causes the brain to gently “sway” within the skull, a motion that acts like squeezing a dirty sponge to flush out toxic neural waste via the cerebrospinal fluid (CSF). neurosciencenews.com/abdominal-pump… #neuroscience #science #Exercise (1/3)

𝗪𝗵𝗮𝘁'𝘀 𝘁𝗵𝗲 𝗿𝗲𝗹𝗮𝘁𝗶𝗼𝗻𝘀𝗵𝗶𝗽 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝗺𝗮𝗻𝗶𝗳𝗼𝗹𝗱𝘀 𝗮𝗻𝗱 𝗿𝗲𝗰𝘂𝗿𝗿𝗲𝗻𝘁 𝗻𝗲𝘁𝘄𝗼𝗿𝗸𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻? This looks like a must read (suppl material bursting with goodies). doi.org/10.1016/j.neur…

眼窩前頭皮質(OFC)が感覚反応の予測filteringを駆動する mouseで音を毎日提示すると一次聴覚皮質A1応答が低下するがOFCvl不活化でhabituationが消失 OFC→A1予測信号は経験で増強しSST介在抑制で予期刺激を負の像として相殺する OA #EI_balance #habituation #papers nature.com/articles/s4159…

Understanding the brain requites more than neuron connectivity: > These waves of calcium, rippling across astrocytes, reflect signaling dynamics that modulate neurons. Neuromodulation is necessary for keeping the brain’s activity level in a functional range, preventing it from either flatlining or erupting in seizures. For years, neuromodulation was thought to be conducted by neurons themselves. While previous work has implicated astrocytes in some cellular signaling, the latest experiments use “advanced techniques to really pinpoint and satisfy beyond a doubt that astrocytes are having a key role in neuromodulation in the brain. An excellent Quanta Magazine articles dives into the history and new evidence for the roles of astrocytes and their control over neurons. It has many implications: "The results suggest that neuron-only brain models, such as connectomes, leave out a crucial layer of regulation."

Co-1st. 論文が出ました．YOLOを手軽に利用でき，nidaq や arduino との連携によりリアルタイムに光刺激などのフィードバックを行えるツールです． -- YORU: Animal behavior detection with object-based approach for real-time closed-loop feedback: science.org/doi/10.1126/sc…

Science Advances に論文が掲載されました！ 霊長類の手はなぜこれほど器用なのでしょうか？ 脊髄と大脳皮質に存在する進化的に異なる神経回路が協調し、安定性と柔軟性を両立させることが「巧みさ」を生み出している可能性が示されました。 science.org/doi/10.1126/sc…

1/14 Our paper is out in @NatureNeuro! nature.com/articles/s4159… We develop a geometric theory of how neural populations support generalization across many tasks. Led by amazing @AlbertWakhloo @wslatton @ZuckermanBrain @FlatironInst @harvardphysics @KempnerInst

【視覚野、目で見てなかった】 新研究により、マウスの視覚野では眼球運動より、ヒゲ動きや匂いを嗅ぐ行動の影響が大きいと分かった。視覚の神経活動は、行動全体の流れを反映している可能性がある。“見る”って思ったより全身感覚の総和なのかも。

新作論文：意識・無意識脳での神経ネットワーク構造の可視化に成功-睡眠中に感覚応答を知覚できない脳の謎にヒント-ハブ細胞の役割とは？大泉ラボ@oizumimとのコラボ。同じデータでマクロからミクロまでネットワーク指標を解析するパイプラインを構築 doi.org/10.1016/j.celr… riken.jp/press/2026/202…

A new @Nature review on biomarkers for Alzheimer’s (AD) and other dementias "Multiple studies now suggest that the most promising AD biomarker is plasma p-tau217, which captures both Aβ- and tau-related aspects of the disease and provides information on a neuronal response to Aβ that predicts neurodegeneration" nature.com/articles/s4158…

「40Hzの音」を聞くとアルツハイマー病の原因物質を除去できる可能性を示唆する論文。 サルを使った実験によれば、40Hz（1秒間に40回）の低音を7日間聞かせた結果、脳脊髄液中のアミロイドベータ（Aβ）濃度が200%以上に急増し、脳内のAβ代謝が劇的に変化し、排出等が促された可能性が示唆された。

𝗦𝗽𝗮𝘁𝗶𝗮𝗹𝗹𝘆 𝗱𝗶𝘀𝘁𝗿𝗶𝗯𝘂𝘁𝗲𝗱 𝗽𝗿𝗼𝗰𝗲𝘀𝘀𝗶𝗻𝗴 𝗶𝗻 𝘁𝗵𝗲 𝗺𝗼𝘂𝘀𝗲 𝗯𝗿𝗮𝗶𝗻 Leaving aside the more extreme discussions about "everything everywhere" and modularity this is a very cool paper. Data from 260 regions and 60K neurons. doi.org/10.1101/2025.0…

For Alzheimer's disease, it's no longer a debate of amyloid (Aβ) versus tau. They are interactive drivers and this new, optimistic review maps out a path towards disease-halting therapies @CellCellPress cell.com/cell/fulltext/…

New preprint on activity sequences: in every brain region, stable over weeks. With Célian Bimbard and Matteo Carandini. Based on data from Célian and the International Brain Lab. biorxiv.org/content/10.648…

Real-time magnetic resonance imaging during gene therapy perfusion of the putamen, using the 'infuse-as-you-go' technique. This permits precise, complete and controlled perfusion. #neurosurgery #GeneTherapy #neuroscience #CED #InfuseAsYouGo #Parkinsons @OSUGeneTherapy @OhioStateMed @NeurosurgeryOSU @OSUWexMed

wow, so perceptual decisions are really not value decisions. Selective engagement of the primate orbitofrontal cortex during value-based but not perceptual decisions biorxiv.org/content/10.110…

Shape-shifting microglia respond to neuronal hyperexcitability @ImmunityCP preview: cell.com/immunity/fullt… on: cell.com/immunity/fullt…

Thanks! And check out our new review on mixed selectivity, please and thanks. doi.org/10.1016/j.neur… thetransmitter.org/this-paper-cha…

Neuroscience is finally beginning to treat time and space the way physics already does, not as fixed backgrounds, but as emergent products of rhythmic geometry. Buzsáki’s new paper shows that memory, navigation, and the very experience of time arise from nested brain–body rhythms working together: slow oscillations setting context, fast oscillations carrying detail, with cross-frequency coupling binding them into a single coherent structure. In this view, time isn’t a linear flow, it’s a measure of change. Space isn’t a static map, it’s a relational scaffold built from oscillatory sequences. Body rhythms aren’t peripheral, they provide the foundational reference frames that cognition builds on. Once you see cognition as geometry in time rather than computation in space, its architecture becomes far clearer. This shift, from static maps to rhythmic fields will reshape how we understand memory, experience, and eventually, consciousness itself. Paper: “Time, space, memory and brain–body rhythms” – Nature Reviews Neuroscience (2025) #neuroscience #brainrhythms #cognition #timespace #memoryresearch #systemsneuroscience #neurodynamics #complexsystems @penrose @IvetteFuentesGu @MillerLabMIT @StuartHameroff @skdh @ericweinstein @drmichaellevin @MIT @Nature @KarlFristonNews @anilkseth @BrainInstitute @donalddhoffman @martinmbauer @tegmark @ylecun

Parietal cortex output neurons form a specialized population code that enhances the propagation of information to a downstream target and potentially improves the accuracy of decision-making nature.com/articles/s4159…