Sam Bloom

Senescent cells secrete chromatin components via senescence-associated extracellular particles --- New study from recently graduated PhD student in the lab, Lana Zaretski, co-supervised by Malene Hansen @thehansenlab and myself. Great job, Lana! biorxiv.org/content/10.648…

🧬Register for the GRS on DNA Damage, Mutation & Cancer🧬 @GordonConf Feb 28–Mar 1 2026, Ventura CA Accepting abstracts for oral presentations! 
📍 Apply here 👉 grc.org/dna-damage-mut… #DNADamage #GRC #GRS #CallForAbstracts

@SenMikeLee DO NOT SELL PUBLIC LANDS!!! NONE OF THEM. NOT ONE BIT!!!! THE PUBLIC DOESNT WANT THIS!!

I want to be COMPLETELY clear: My bill exempts ALL parks, monuments, wilderness areas, etc., from the federal land sale. We exempt 15 categories of land, including land where people have valid existing rights. And even then, it's less than ONE PERCENT of federal land. This is to help American families afford a home. Read the language for yourself, & don't fall for the scams (& some honest mistakes) pushed by some.

Introducing Telo-seq: a new tool from @SalkInstitute and Oxford @Nanopore that will revolutionize the study of aging and cancer. Scientists can now measure and sequence telomeres on individual chromosomes with unprecedented resolution. #SalkHealthyAging salk.edu/news-release/u…

We are excited that our study on telomere sequencing in collaboration with @nanopore is published nature.com/articles/s4146… We developed Telo-seq, a method to determine the length and composition of entire human telomeres in bulk, chromosome arm and in some cases allelic resolution

Always fun to hang out with this crew!!! @NassourJoe @ArnoultLab @tobiastschmidt @sambloom28 @makotothayashi2 ! Thanks @TeloEMBO2024 for a great meeting!

By elucidating endothelial regulation of insulin sensitivity via Arf6 signaling, this study provides a new mechanism of vascular dysfunction and diabetes @aroundthehorn7 @DnisseGrabiela ahajournals.org/doi/abs/10.116…

Endothelial-Specific Reduction in Arf6 Impairs Insulin-Stimulated Vasodilation and Skeletal Muscle Blood Flow Resulting in Systemic Insulin Resistance in Mice dlvr.it/T4l8HB

@ZachSClayton @CUDeptMedicine @CUAnschutz Congrats, Zach!

I am thrilled to announce that I just accepted a position as an Assistant Professor in the Division of Geriatric Medicine in the @CUDeptMedicine at @CUAnschutz! Incredibly grateful for the mentors and colleagues I have had along the way!

hot off the press onlinelibrary.wiley.com/doi/10.1111/ac…

Our latest review 'Telomeres as hotspots for innate immunity and inflammation' is now live @repair_dna! Here, we describe how dysfunctional telomeres activate innate immune pathways and fuel inflammaging. Check it out @Sprzetocka @KarlsederLab doi.org/10.1016/j.dnar…

#PaperSpotlight: On October 2, 2023, researchers from @UUtah, @FloridaState and @DeptVetAffairs published a new research paper in Aging's Volume 15, Issue 19, entitled, “Reduction of double-strand DNA break repair exacerbates vascular aging” DOI: doi.org/10.18632/aging…

Aging Biology : Senolytics Reduce Endothelial Cell DNA Damage and Telomere Dysfunction Despite Reductions in Telomere Length -------------- Samuel Bloom, Anthony Donato and coworkers. agingcelljournal.org/Archive/Volume…

📢New Article📖in GeroScience Glycocalyx-targeted therapy ameliorates age-related arterial dysfunction by Daniel R. Machin et al. link.springer.com/article/10.100… @UUtah @floridastate #endothelium #hyaluron #arterialfunction #aging

📢New Recommended Reading📖 #Aging results in DNA damage and telomere dysfunction that is greater in #endothelial versus #vascularsmoothmusclecells and is exacerbated in atheroprone regions by Samuel I. Bloom et al. link.springer.com/article/10.100… @UUtah #dnadamage #telomeredysfunction

Hot off the press! Donato and colleagues review the mechanisms of endothelial cell senescence and its contribution to metabolic and #cardiovascular diseases: rdcu.be/cR2no