Si Fang

62 posts

Si Fang

Si Fang

@sifang1678

Senior Research Associate in Genetic Epidemiology & Causal Inference @MRC_IEU @BristolUni

Bristol, England Katılım Ağustos 2014
535 Takip Edilen265 Takipçiler
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Si Fang
Si Fang@sifang1678·
I'm glad to announce that our polygenic score-metabolite atlas has been published on @eLife 🥳 This atlas contains associations between 125 PGS for complex traits and 249 NMR-derived metabolic traits from up to 83,004 individuals in the UK Biobank. elifesciences.org/articles/73951
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Alice Carter
Alice Carter@alicerosecarter·
There's been a lot of discussion recently about the misuse of MR, except the proliferation of incorrectly drawing your assumptions doesn't seem to stem from the recent explosion in papers. Rather, many high impact papers seminal to the field feature an "incorrect" arrow a 🧵
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Marie Sadler
Marie Sadler@smarie_smarie·
Can we use biobank #EHRs to study the genetics of drug efficacy? 💊🧬 How to best model drug response and longitudinal biomarker progression in an unbiased manner? 📊 Do #PRS predict treatment outcomes? Check out our new preprint doi.org/10.1101/2024.0… and the thread 🧵 below👇
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george davey smith
george davey smith@mendel_random·
I'm talking on "Mendelian randomization: what it was, what it is, and what it should become", in person at Sir Ambrose Fleming Lecture Theatre @ucl London, 25th April 3.30-6pm (with reception) or online (you can drink during it), MC'd by @AdamRutherford forms.office.com/pages/response…
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Louise AC Millard
Louise AC Millard@louise_millard·
Devastated I won't get to celebrate its anniversary each year (as I of course do for all my papers) ... Our paper evaluating a global randomisation test for MR is now published in EJE – link.springer.com/article/10.100… Thanks to @mendel_random and Kate Tilling
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george davey smith
george davey smith@mendel_random·
Yes indeed if there is nothing beyond the mechanical analysis - no triangulation in other words. For reasons to give to editors see pubmed.ncbi.nlm.nih.gov/37796951/ and m.youtube.com/watch?v=jQmlba… and pubmed.ncbi.nlm.nih.gov/38048796/
Eric Fauman (he/him)@Eric_Fauman

Can I stop reviewing MR papers now? MR is an amazing technique, but the papers I'm asked to review just download 2 sum stats files, run the standard packages and provide little if any biological insight I've recommended against publishing all the manuscripts that have come my way

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Golam Khandaker
Golam Khandaker@golam_khandaker·
🔥 Do immune pathways causally affect psychiatric conditions? 🔥 Could they be new treatment targets? Check out our most extensive proteo-genomic study to date of 735 immune related proteins & 7 conditions (SCZ, BPD, MDD, ANX, ADHD, Autism, Alzheimers). medrxiv.org/content/10.110…
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Brenda Cabrera Mendoza
Brenda Cabrera Mendoza@brendacabreram·
Very proud of our latest study, where we explored the impact of assortative mating, participation bias and socioeconomic status on the genetic risk of mental health traits. Check it out! 😊 nature.com/articles/s4156…
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Liza Darrous
Liza Darrous@LizaMGD·
Check it out 🧵👇! Our PWC-MR approach aims to tackle the some of the sources of bias that affect MR causal estimation: heterogenous causal effects & confounding. rdcu.be/dyJ3h Often studied separately, PWC-MR has shown that classifying instruments into clusters...(1/n)
Zoltán Kutalik@zkutalik

Just out now! Our pheWAS-based clustering of instrumental variables can reveal heterogeneous causal effects & confounding. Plus facilitates the interpretation of the underlying mechanisms. We apply it to the BMI->education relationship. Spearheaded by @LizaMGD

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george davey smith
george davey smith@mendel_random·
What could be more thrilling than 3 days in ever-sunny Bristol debating the future of Mendelian randomization 19-21st June 2024? The 6th International MR conference, in the year MR gets its key to the door - but where will that door lead to? mendelianrandomization.org.uk
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george davey smith
george davey smith@mendel_random·
Looking forward to visiting sunny Exeter to talk on “Noodles, No Nulls and Numb Skulls: Threats to the future of Mendelian Randomisation” on 21st September at 11.00am (UK time). Also available online for those not lucky enough to live in sunny Exeter Universityofexeter.zoom.us/j/96175100732?…
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Verena Zuber
Verena Zuber@VerenaZuber·
Our multi-response Mendelian randomization MR2 model for the analysis of multiple related outcomes → To account for information shared between outcomes → To define shared causes of disease is out @AJHGNews cell.com/ajhg/fulltext/… For a 🧵 please check twitter.com/VerenaZuber/st…
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Verena Zuber@VerenaZuber

We introduce a novel Multi-Response Mendelian randomization (MR2) model for the analysis of multiple related outcomes: → To account for information shared between outcomes and → To define shared or distinct causes of disease. Preprint on biorxiv.org/content/10.110… and 🧵below 1/

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Flo Martin
Flo Martin@_flomartin·
Another exciting addition to our public engagement webinar on July 11th - @mrc_ieu's very own @eimear_foley1 to talk about her engagement & content curation work @Mental_Elf 🧠 Sign up using the link below - this is not one to miss! 👇
ECR SSM@ECR_SSM

Our second speaker is @eimear_foley1 an Elf Coordinator with the @Mental_Elf blog, talking about how social media and blogs can help close the gap between research and clinical practice. Join us 🗓️Tues 11 July 3-5pm, sign-up: bit.ly/3NNhH4X

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george davey smith
george davey smith@mendel_random·
So this is happening tomorrow at 3pm in Boston, followed by what I've been told will be a champagne reception (tho' I fear warm Budweiser), in person @broadinstitute ground floor auditorium (no need to book - just turn up) & online (eg 8pm UK time) youtube.com/watch?v=tQeH5q…
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Keşfet

@ucl @AdamRutherford @mendel_random @mrc_ieu @AndrewHaoyu @nilanjan10c @XihongLin @JiananZhan