Stathi
3.9K posts
Stathi
@stathi_
MSc Mathematics, Quantitative Developer
Katılım Ekim 2011
146 Takip Edilen137 Takipçiler
@ethanjweiss @realDaveFeldman Is this truly hard for people to understand?
The thing causing ⬆️TG is also causing atherosclerosis via a completely different mechanism (i.e. not via TG).
Isn't this obvious?
x.com/i/status/20386…
Stathi@stathi_
It's not the TG it's the thing causing the TG. Likewise many believe it's not the LDL per se, but the thing(s) causing the LDL to become atherogenic. I guess causality graphs are hard. Maybe my professional experience in both financial mathematics (sensitivity analysis) and network graphs (shortest path and differentiation algorithms) allow me to easily visualise these structures.
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@realDaveFeldman Dave this is all your fantastic theory until you show me actual data to support this idea. Do you have any?
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I am surprised that nobody is surprised by these results. It feels quite earth-shattering to me but what do I know?
At 6 months, olezarsen reduced triglycerides by 63.9%, remnant cholesterol by 71.9%, and apolipoprotein B by 16.0% over placebo, with no difference in LDL-C.
And yet no difference in plaque at all at one year? None? So many questions and so few answers but I think this is one of the most interesting null results I have seen in a long time.
Circulation@CircAHA
#SimPub #ACC26 In CCTA substudy of Essence-TIMI 73b (RCT of olezarsen vs. placebo in patients with hypertriglyceridemia), no difference in non calcified, coronary plaque volu... @marstonMD @maciejbanach @AndreZimerman @michael_t_lu @BrianBergmark @BudoffMd ahajrnls.org/4m4ZwHK
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@anonemus349832 @caloriesproper2 Right. So your cause is "they eat too much because they like it". Genius. Obesity is solved.
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@stathi_ @caloriesproper2 why does ci>co? because animals in general like to eat...a lot. and especially if they have ice age phenotypes.
x.com/alphafox/statu…
AlphaFox@alphafox
Woman breaks down after seeing how much food she actually eats every day: 🤢
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The science isn't settled until you agree carbs and seed oils cause obesity
Then, you have an open mind and are capable of critical thinking
"We're finally making progress"
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Something causes CI to be greater than CO.
Saying that "weight gain is caused by CI > CO" lis like saying "weight gain is caused by weight gain". This is why people call CICO a tautology.
"a bank balance reflects your wealth" - and "CI > CO" reflects weight gain, but doesn't say why it's occurring
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@stathi_ @caloriesproper2 i don't understand this comparison at all. a bank balance reflects your wealth. obesity is both a reflection of your energetic wealth and is caused by it.
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@anonemus349832 @caloriesproper2 You're missing the point. Saying "energy surplus causes obesity" is just as dumb as saying "bank balance causes wealth"
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@stathi_ @caloriesproper2 yes you could gain weight on ozempic if you forced yourself. glp1 removes the compulsion to do that by blocking the receptors that drive hunger. without glp1, due to ice-age phenotypes persisting in the modern era, they would just get fatter and fatter.
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@anonemus349832 @caloriesproper2 Clearly ozempic doesn't cause weight loss. It's the calorie deficit.
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@stathi_ @caloriesproper2 energy surplus is the cause of obesity and can cause other problems too like cancer.
behold what humans can achieve without seed oils
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It's not the TG it's the thing causing the TG.
Likewise many believe it's not the LDL per se, but the thing(s) causing the LDL to become atherogenic.
I guess causality graphs are hard. Maybe my professional experience in both financial mathematics (sensitivity analysis) and network graphs (shortest path and differentiation algorithms) allow me to easily visualise these structures.
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@caloriesproper2 It's not low carb, it's the calorie deficit
It's not no seed oils, it's the calorie deficit
It's not exercise, it's the calorie deficit
It's not ozempic, it's the calorie deficit
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@caloriesproper2 it’s become he cut calories and junk food , not “cutting carbs and seed oils “.
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this guy is teaching me about nutrition
he's qualified to do so because he lost weight by quitting carbs and seed oils
only about 50 pounds to go until he no longer has obesity
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@exfatloss @BerbarianWizard People only talk about DNL in liver, which does seem fairly low, but apparently the capacity for DNL in adipose is massive. Why convert in liver just to transport to adipose? Makes more sense to do the job in the adipose.
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Unfortunately the "low DNL" thing doesn't seem to be true, at least in some metabolically wrecked people like myself. I can very quickly gain fat, like half to one pound a day, by eating nearly zero-fat starch + sugar combined.
High volume also gives me zero satiety. COMPLETELY unrelated.
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If fat intake stays low, potatoes are very hard to get fat on.
There’s no dietary fat to store, and converting carbs to fat (DNL) is minimal and inefficient in humans. So even with high intake, fat gain stays limited.
On top of that:
high volume → high satiety
high potassium → better fluid balance, less water retention, improved glucose handling
You can eat large amounts and still lose weight. Even something simple like air-fried potatoes with a small amount of coconut oil works fine.
Their protein content is underrated too.
~20g/kg on paper, but that underestimates it because of α-keto acids, which can convert into amino acids in the body and increase usable protein.
That’s why Ray Peat compared potato protein to milk, not in quantity, but in biological usefulness. The amino acid profile is also favorable for a plant food (high lysine, low tryptophan and cysteine).
a🦭.☘︎ ݁˖@wichuthena
if potato's were 0cals the world would be a better place
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@nullbotto Ozempic doesn't cause weight loss. It's the calorie deficit! Duh
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The thing that shut down your appetite and made you not eat enough protein DID NOT CAUSE MUSCLE LOSS.
That was the 1st order effect of the thing!
Dr. Mike Israetel@misraetel
Ozempic and Mounjaro DO NOT CAUSE MUSCLE LOSS! Losing a ton of weight without sufficient protein (1g per lb bodyweight per day) and failing to train with weights (even just 2 sessions of 20 minutes each per week) absolutely does cause muscle loss. Eat enough protein, lift, and only lose about a pound per week (no faster) and you’re unlikely to lose muscle on weight loss drugs.
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Stathi retweetledi
@Tellit007 I would faithfully engage with this post if it wasn't AI slop
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"See, I told you. CICO is a total myth."
You changed one side of an equation, watched it balance, and declared the equation broken.
That is what "CICO is a myth" actually means.
Here is what happened. Someone goes low carb. Appetite drops. They eat less without tracking it, without intending to, without noticing. High protein and fat satiety does that.
The calories-in side quietly falls.
They lose 30 lbs.
Now they post about it.
"I wasn't counting calories. I wasn't in a deficit. CICO is disproven."
But what about the calories going out?
Total daily energy expenditure. Basal metabolic rate. Non-exercise activity thermogenesis. Thermic effect of food.
None of it measured. None of it tracked. None of it even considered.
The body ran the experiment. The body published the result. Thirty pounds of adipose tissue does not disappear because of vibes.
It disappears because more energy went out relative to what came in.
That is CICO. Working exactly as described.
Low carb is valuable. For many people it makes the deficit easier to achieve and sustain. That is real. That matters.
But "easier to achieve a deficit" is not the same as "deficit not required."
The zealots changed the CI.
They just forgot to read the CO.
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I wrote to @johncleese a while ago to invite him on my show for a chat. He never bothered to respond even though I contacted him via a mutual friend. Perhaps now, I'm thankful that our chat never occurred.
John Cleese@JohnCleese
Does this silly little man not understand that Islam is a very aggressive belief system, threatening death to anyone who does not convert to Islam The Buddhists, the Taoists, the Scottish Presbyterians, the Hindus and the Sikhs and the Confucians and the Catholics don't go around shouting about beheading people they disagree with Is this too much for your tiny little brain to take in ? Oh. The doorbell rang. The police I assume...
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@caloriesproper2 Good luck with that though.
"Oh, you don't want low-e glass? That'll be $3000 in computer modelling costs to prove your house will be energy efficient"
"Oh, you want incandescents? We don't stock them because LEDs are superior in every way"
True stories 🤦♂️
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Wrong. Backwards. Circadian health is *more important* in the modern environment than it was in the past.
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@caloriesproper2 This was great. Perfect type of criticism.
I'm assuming that's the retracted paper.
They should get this guy to review the upcoming papers @realDaveFeldman
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"Keto CTA Study MANIPULATED Charts!? Statistical Violations!?" by John Slough II, an expert on statistical analyses who should really be hired by the Keto CTA study authors to help moving forward youtube.com/watch?v=AE8VGc…
YouTube
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so apparently muting an account doesn't prevent you from seeing their replies to you
huh
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Someone I know has apparently been taking Benadryl every night before bed to help her fall asleep, for years.
She's a 30-something young professional working in tech, and apparently no longer sleeps well without Benadryl. Travels with it, etc.
Anyone know someone like this?
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Carnivore diet enthusiasm seems to be waning quickly
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