Joseph

@namimzz @cremieuxrecueil I can also post AI slop

@wethebots_ @cremieuxrecueil It seems you are part of "a lot people"

Another example of the fact that, unless you're willing to make life unbearable, reducing consumption is not the solution to climate change.

there will come a time where people will believe the words of AI over their own eyes and ears.

@bryan_johnson Dang all it took for a billionaire to understand the struggle of the commons was DMT

Society was built to make money. Indifferent to your health and sanity. For example, we did not evolve to: + sit 10 hours a day + have our attention fractured 300 times daily + compare ourselves to millions of others + travel 9 time zones in 13 hours + tolerate sounds above 85 dB causing hearing loss + outsmart algorithms hijacking our reward system + breathe fine particulate air pollution + live under 16+ hrs of artificial light a day + have 3 courses of antibiotics before age 2 + eat ultra-processed foods for 60% of daily calories + consume 17 teaspoons of added sugar a day So if you're feeling down in the dumps, maybe fatigued, a little or a lot depressed, anxious, that's why.

@DrKERMD @zalaly just engagement farming, I hate to see it, but the difference is accounted for in baseline BMI. Bad science, fake news for engagement and that's were thing are going everyone if fighting for attention with misleading headlines.

I keep seeing this study being posted - the important point being that the patients in this study were all diabetics and the comparison was between those on GLP1 or on SGLT2i drugs. For non-diabetics not on other meds, this study is much more applicable, in which they found no increased risk of NAION compared to placebo in both diabetics and non-diabetics: bjo.bmj.com/content/early/…

GLP-1 drugs are associated with a 35% higher risk of NAION, an eye condition that can cause sudden vision loss. About 6 to 10 extra cases per 10,000 users over 3 years. The association is specific to NAION. No other eye conditions were affected.

why is there suddenly hundreds on AI MDs on my feed, they should be required to post a medical license number.

this is the blowoff top

Seeking comfort & satiety is the fastest way to the grave

@agingroy as a preventative intervention it should definitely show a strong benefit, you don't cure Alzheimer's you prevent it. Curing Alzheimer's would be equivalent to turning back time if they ever find that it won't just apply to the brain it would apply to every other organ.

Both GLP-1 drugs failed to treat Alzheimer's. But one left a strange clue. Liraglutide. 204 patients. Primary endpoint: missed. But on an unpowered, unplanned MRI measure, brain atrophy was roughly 50% less than placebo. Semaglutide. Thousands of patients. EVOKE and EVOKE+: negative on every cognitive measure. Same receptor. Both reach the brain. Nobody can explain the divergence. 15 million people take GLP-1 drugs. Neither one is an Alzheimer's treatment. Not yet. Maybe not ever. Published in @NatureMedicine and @TheLancet. Both @NovoNordisk

@dissidentwest I sense a bell curve meme here.

We need a slur for people who think AI is conscious.

The dollar has lost 21.1% of it's buying power since 2020, abortion rate has increased 21.1% since that time period. Interesting per se

@siimland I personally will discontinue this supplement after my supply is out, looking forward to having a bit more dht as astaxanthin + all my other carotenoids are keeping me at female levels.

Astaxanthin was tested for lifespan in mice. In 2023, it increased lifespan by ~12% in male mice But a new 2026 study found no effect. The big difference: dose and timing. Full video breakdown: youtu.be/ZTwlmD2BqpY

@siimland I heard that at the high dose astaxanthin is actually actually pro oxidant so it's interesting to see these results. Reminds me of of the superoxide dismutase knockout worms that counterintuitively lived longer.

@Aella_Girl As birth order increases so does the age of the father, Y chromosome bearing sperm are generally more susceptible to damage since only a single copy of Y chromosome exists. Physically and mentally stressed out fathers are more likely to have females.

wait what

@Tetrahydropyran @cremieuxrecueil yes it's obvious that glp-1r are protective vs non treated diabetes group, both groups are diabetics.

@cremieuxrecueil I wonder what would happen if we compared GLP-1R with metformin or DPP4i. How can we know SGLT2i don't protect against NAION? They help heart failure and CKD.

The latest GLP-1RA NAION analysis is a cohort study comparing diabetics on GLP-1RAs to those who use SGLT2is. It found about 8 extra cases per 10,000 users. And it also found literally nothing for any other vision-related outcome.

@cremieuxrecueil baseline bmi of the groups normalized the difference in cases, there is not true risk increase.

@zalaly the NAION case risk increase can literally be accounted for in baseline BMI, this is really bad science. GLP-1RA 35.77 ± 7.01 SGLT2i 32.84 ± 6.30

Why we think this is real, not a fluke. Two alternative explanations to rule out: 1. People on GLP-1 drugs may see eye doctors more often and pick up incidental diagnoses. 2. GLP-1 drugs may cause general eye problems, with NAION just one of them. We checked. Neither held up. ▸ Diabetic retinopathy: no difference ▸ Macular degeneration: no difference ▸ Retinal vascular occlusion: no difference ▸ Optic neuritis: no difference ▸ Eye-care visits: similar in both groups The signal is specific to NAION.

Do GLP-1 drugs increase the risk of vision loss? Specifically, a condition called NAION: a sudden loss of blood flow to the optic nerve that can cause vision loss. We looked at this in 588,000 people. The answer, in our new @JAMANetworkOpen paper, is yes. 🧵 jamanetwork.com/journals/jaman…

@agingroy dapagliflozin is now $15 for 90 days on marc Cuban pharmacy, the sample size of the study was too small plenty of treatment group shortened telomeres. The mechanism of action is removal of senescent cells leading to a greater average telomere in white blood cells.

First drug ever shown to lengthen telomeres in a randomized trial. Henagliflozin, a diabetes drug, for 26 weeks. Results: - Treatment group: 90.5% had longer telomeres - Placebo group: 65.6% - Difference: statistically significant, p<0.01 This isn't a supplement study with 12 people. It's a randomized placebo-controlled trial of a drug millions already take for blood sugar. Telomere shortening is one of the 12 hallmarks of aging. Every decade, your telomeres lose about 14% of their length. This is the first time a pill has reversed that trajectory in a controlled experiment. SGLT2 inhibitors already extend life in heart failure patients. Now we might know one reason why.

@bryan_johnson the cause is very straight forward you've been using the strongest retinoids for a while, it's a known issue.

I started milking my eyelids. Here's the situation. My eyes have been dry/irritated/red for the past year or so. I started using eye drops to moisten and it didn't make a difference. So I went to see an eye doctor. The source of the problem is that my meibomian glands, the tiny oil glands lining the eyelids, were clogged up. Without the meibum they secrete, the tear film on my eye evaporates in seconds which is bad for eye health. We're not sure of the cause of the dysregulation. We have few theories that we're looking into. Taking a closer look with infrared meibography, the imagery showed that my meibomian glands were congested, distorted, and partially dropped out. This is bad news because atrophied glands don't regrow! It's situations like this that makes me wonder why we do not have a better operating manual for the human body. How could I have prevented this from happening and why didn't I catch this sooner!? I did additional tests to assess the damage and my situation now. The Schirmer test (paper strip measuring tear wetting over 5 minutes) came back at 6 and 6.5 mm. A borderline reading consistent with mild dry eye. A healthy reading is typically 15 mm or above. Here's what I'm doing now to try and nurture my remaining glands back to good health: 1) Forma RF, Radiofrequency (microwave) heat applied from outside the lid, melting the obstruction. 2) LipiFlow, a device that sandwiches each eyelid: heat from the inside, pulsed pressure from the outside, squeezing the obstruction out. 12 minutes, both eyes. 3) Both capped at 41°C, not the standard 42°C, to spare eyelid collagen and elastin. No thinning skin, no premature sagging. 4) IPL around the eyes that shut down the abnormal blood vessels feeding chronic lid inflammation, the engine of MGD. 5) Manual gland milking, the doctor squeezes the lid margin between two instruments, forcing the plugs out. Hard, pasty secretions came out initially. The second and third mechanical milking the glands are returning to a normal, expected oily state. 6) Daily upkeep includes warm compresses, lid hygiene, omega-3 to keep secretions thin and glands moving. My next check in is 3 weeks form now. My doctor mentioned that meibomian gland dysfunction in her patients has increased since Covid, likely driven by the rise in screen time. When staring at screens for long stretches, people blink less frequently and less completely. Normal blink rate is roughly 15-20 times per minute but drops significantly during screen use. Incomplete blinks mean the meibomian glands don't get fully expressed, which over time contributes to gland dysfunction and evaporative dry eye. It's worth you getting checked for this and a good practice generally to make sure your eyes are in good health.

@DrMakaryFDA @US_FDA is this just to speed up insider trading?

A milestone day for clinical trial innovation. We’re announcing the first real-time clinical trials, where @US_FDA can see data signals and endpoints in real time. A quick explainer: