Cris Mar

It was a great @EthCC edition. Here’s my bittersweet take: - definite bear market vibes, fewer people, fewer tourists too - the bear market, combined with agentic AI, has been an extinction event for the crypto job market. Plenty of people are looking for new roles, but opportunities are scarce - hardly anyone cares about the talks anymore. People just point the replay to their agent and get a summary. I think the next edition should embrace that and build an agent track for speakers who did not make the official schedule, so they can record a video and publish a transcript. Done well, that might get more attention than an actual slot - a significant number of people and projects are out of money. Many pretend otherwise, but it shows. Better to be honest and transparent - Many are sitting in stables. They are still around, but they have lost faith in most tokens. The naive era of tokens without substance is dying, and that is for the best - the @ethereumfndn cares, it matters, and it is worth supporting. - There are still quite a few OGs around with drive and focus, and that is motivating - Many projects have dropped the act of pretending to care about decentralization and cypherpunk ethos. They think bending the knee to institutions will make up for their failure to reach PMF and profitability. It will not. - incumbent onchain lenders seem to believe their only path to survival is selling cheap liquidity to yield-bearing assets. It shows a lack of drive and conviction, and it will not work - it is better not to have a zero-sum mindset. Morpho learned that the hard way, and their wall-of-shame humiliation was deserved. It was hilarious. Looking forward to taking a sponsor slot for EthCC 10.

this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to drug targets > design a custom mRNA cancer vaccine from scratch > genomics professor is “gobsmacked” that some puppy lover did this on his own > need ethics approval to administer it > red tape takes longer than designing the vaccine > 3 months, finally approved > drive 10 hours to get rosie her first injection > tumor halves > coat gets glossy again > dog is alive and happy > professor: “if we can do this for a dog, why aren’t we rolling this out to humans?” one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline. we are going to cure so many diseases. I dont think people realize how good things are going to get

How we [un]wind RWAs without any OTC liquidity. We got kind of into the atomic vibes.

loan.bordel.wtf Commit any USDC you've got lying around to help get it over the line!

I'm Boris and I created Claude Code. I wanted to quickly share a few tips for using Claude Code, sourced directly from the Claude Code team. The way the team uses Claude is different than how I use it. Remember: there is no one right way to use Claude Code -- everyones' setup is different. You should experiment to see what works for you!

over the weekend, i built an app that i sincerely hope you will never have a need for, but if you do happen to need a friendly, free, private mri viewer designed to make it easy for you to track tumor progression, you can try it here: miraviewer.org here's the story: as some of you may know, last last september, my six year old daughter mira was diagnosed with an extremely rare brain tumor called an adamatinomatous craniopharyngioma, and since then our family has been doing everything we can possibly do to find a cure for her. we tortured chatgpt deep research, put together our own private research team, raised $1.4M and donated it all to @HankMitraLab research thanks to $MIRA, explored every remotely applicable drug whether on the market or not, and even began working with md anderson to develop a personalized vaccine that we hope can lead to a more permanent cure unfortunately, we received the devastating news last march that the tumor has continued to grow since her initial surgery, and we had to start to consider more drastic options which would have seriously impacted mira’s quality of life. thankfully, with the help of dr. sabine mueller @UCSFChildrens and the @HankMitraLab at the university of colorado, in april, we started her on an alternative but extremely experimental treatment for this disease. to our unimaginable relief, her tumor has responded extraordinarily well to this treatment which combines tocilizumab (an arthritis drug that blocks IL6 receptors) with avastin (a colon cancer drug that inhibhits VEGF proteins). we know this, because mira gets an MRI scan of her brain every few months. and every time we get a new scan, the first thing we do is compare it against her last scan. so we have to find the matching weight of the scan, and then find the same plane, and then carefully find the slices of the scan where the tumor is visible, and then find the closest match to last month’s scan, then adjust the zoom, rotation, and brightness / contrast so they all look the same. we got pretty good at this. but it shouldn't be this hard. so i built miraviewer.org last weekend using gemini 3 with some gpt 5.2 xhigh. you just import your DICOM MRI files (either zip, files or a folder), and you can align all of your scans across multiple dates instantly, just click and drag a rectangle around the tumor on any image, and it will use some very clever algorithms to automatically align up and find the closest matching slice from all your other scans, match the brightness / contrast, rotation, pan, zoom, and even shear to make sure the registration is as close as possible, and make it as easy to possible to compare tumor progression. it has a grid view so you can see all your scans for the same location all at once, and an overlay view so you can quickly compare two scans visually (by holding down the space bar to toggle quickly between two scans), along with tools to animate your scans both within the same sequence as well as over multiple scans to show progression. there is no server, it runs entirely locally on your browser - nothing ever gets uploaded and it's all open source: github.com/blader/MiraVie… if you've found this useful, please consider a donation to the @UCSFChildrens hospital foundation, who has given us extraordinary care over the past year or so: donate.ucsfbenioffchildrens.org/fund/childrens…

My annual MRI scan gives me a USB stick with the data, but you need this commercial windows software to open it. Ran Claude on the stick and asked it to make me a html based viewer tool. This looks... way better.

stop texting 5 different women and start texting 5 claude code terminals and maybe you'll escape the permanent underclass

celestia raised $156m before launch it was marketed like it had just solved the mysteries of black holes in reality it is providing DA service to a bunch of dead chains might be the worst tokenomics you’ll ever see tokenomics were so bad that new projects literally started marketing “don’t worry, our locked tokens won’t be staked” as if that wasn’t supposed to be the default anyway staking tia was marketed as some magical endless airdrop opportunity but in reality it was just an exit liquidity trap engineered so vcs could dump their staking rewards forever an entire generation got wiped out for staking this thing at the top now a few clowns are still trying to market it as "all tokens are unlocked now" probably because they’re desperate to keep dumping their infinite inflation staking rewards somehow it still sits at $700m fdv zero

What happened to the smartest person you went to school with?

🚨 MegaETH rug protocol 🚨 🔕 Stay away 🔕

I asked @vnovakovski the founder of @Lighter_xyz why other platforms are still building for L1s and citing performance reasons? "idk, maybe they made a technical choice 2 years ago that's not relevant today. Those guys should go talk to @SuccinctLabs." He says there's no performance limitation to L2s - Lighter could run at 1m TPS now if it needed to. "The more secure the L1, the more performant the L2." It seems Lighter is an L2 for one simple reason. A better product for users.

The best products of the 21st century have yet to be shipped. With 21st, any idea can find its aesthetic and design, even if you aren’t a designer. Meet the first vibe crafting tool for everyone…. So every product can have soul.

Decentralization underpins permissionless blockchains, but what about geography? 🌍 Our new study explores this often-overlooked dimension of crypto. (1/n)

Good interview from Roman Storm. His trial is coming soon in 10 days. Privacy of messaging without backdoors is now widely accepted, and many in business and government regularly use tools like Signal. Given the extremely regular hacks of centralized databases that we see today, improving privacy in other domains (including payments, identity, AI) is not something to be "balanced" against security, it's a necessary _part_ of our security. I hope 🇺🇸can lead the way in making a more secure world with stronger freedoms and fewer data leaks a reality. The first step is sending a clear signal to developers that this important work is welcome. #FreeRomanStorm

𝗘𝘁𝗵𝗲𝗿𝗲𝘂𝗺 𝗧𝗵𝗲𝘀𝗶𝘀 — Root Chain for the World Computer We invest in, build on and love Ethereum ❤️ — since 2014. cyber.fund/content/eth Here we share our conviction & discuss: ‣ Ethereum's state ‣ Rollup-centric future ‣ L1 & DA moats ‣ ETH value accrual 🧵

UPDATE 🚨 The whole story on Hyperliquid & $JELLY 👇 background context > hyperliquid (HL): decentralized perp exchange > HLP: internal liquidity vault of hyperliquid > jelly token: small market cap (~$10-20M initially) what happened > trader wallet (0xde95) opened huge ~$8M short on jelly > trader purposely removed margin, forcing hlp to inherit and auto-liquidate the massive position > simultaneously pumped jelly price on-chain, squeezing shorts hard > jelly pumped from ~$10M to over $50M market cap in under an hour > hlp initially suffered huge unrealized loss (~$12M) second exploitation > amid chaos, new wallet (0x20e8) opened big long, quickly profiting ~$8.2M on hyperliquid > exchanges like binance and okx noticed volatility and quickly listed jelly perps, amplifying activity hyperliquid's response > validators rapidly decided to delist jelly perps > adjusted oracle price significantly down to $0.0095 per jelly, closing all open positions > publicly communicated quick actions transparently > normal users (excluding flagged wallets) automatically compensated, no action needed financial outcomes > hl turned potential multimillion-dollar loss into ~$703K realized profit after adjustment > hlp depositors fully protected and even profited (~$687K daily profit), despite initial scare market perception > positive: praised for swift, decisive actions protecting depositors > criticism: controversy around forced oracle adjustments and decentralized governance transparency why this matters highlights big vulnerabilities in decentralized perp exchanges (oracle pricing, liquidity vaults, forced liquidation) emphasizes need for fast, transparent governance and intervention mechanisms shows controversial tradeoffs protocols might need to make to protect depositors during exploits important lessons here for anyone participating or building in defi and perpetual markets

@megaeth Does anyone know how to feed your bunny?)

SOLD OUT! Thank you to all 5,000 of you with a shared vision of The World Computer The Fluffle Phase 1 saw • More real users get skin in the game • No gas war Next up: public testnet ...and don't worry, we're better at building blockchains than NFT mints.

Today, the on-chain voting on the creation of OpCo in @arbitrum begins, which has budgeted $3,684,000 per year for salaries of 12 employees. According to my calculations, the current management costs do not exceed $500,000 and I consider it incorrect to propose an alleged improvement with costs almost 10 times higher. But there is a ray of sanity and hope in this fucked up mess. The @lobbyfinance project will vote against with all of its 20,698,158 ARB. If you have ARB lying around and you forgot to delegate them to us, do so 🗳️tally.xyz/gov/arbitrum/d… If you vote yourself, then look carefully at the proposal and you will see that the excessively high salaries outweigh all the good ideas in this proposal tally.xyz/gov/arbitrum/p…