Nick
3.2K posts

Nick
@Lawbitrage
I am an investor. In my free time, I read sovereign bond contracts and the New England Journal of Medicine.

This is a great discussion about the state of drug development. Also, I was excited to hear @JMaraganore mention that he’s writing a book!


Medical breakthroughs this week Read it here: substack.com/home/post/p-19…




Encouraging news for patients living with multiple myeloma. The FDA has expanded the use of a combination treatment for multiple myeloma, allowing it to be used earlier when the disease returns or starts to worsen. “This approval is due to years of scientific progress and will be a meaningful improvement for many patients,” says Dr. Gruenbaum. Learn more: bloodcancerunited.org/resources/news…





Great to see eventually these initial (strong) signals of benefit for gotistobar vs docetaxel in 2nd L SqNSCLC just presented at #ELCC26 A space where we're clearly struggling to raise the bar! Any other CTLA4i believer out there? @IASLC @myESMO





This is totally out of control: There’s 0 - I repeat 0 - evidence any of the LLM work did anything meaningful for Rosie’s cancer I’m sorry to rain on the parade here. I know we want to believe. But, it’s possible to do a lot of things and have nothing happen @paul_conyngham co-administered α-PD-1 (conventional immunotherapy) with a TKI and the mRNA. It’s probably the most effective cancer immunotherapy of all time. This isn’t a small detail! There’s no evidence his process (beyond FDA approved doggie α-PD-1) had any impact on disease progression. The most parsimonious explanation is a partial response to α-PD-1 I get it. The chat bots make for a great story (although checking multiple LLMs isn’t validation), but it’s really just a neat story. It’s fundraising copy. Before he starts selling the “custom neoantigen mRNA vax” story to consumers, he should provide some evidence it did anything! That’s responsible citizen science This is just storytelling for the AGI true believers. Specifically, a story in search of venture money




Sorry to be the downer because this is an impressive story in some senses. But it is ~trivially easy to make a single mRNA vaccine. It's not hard. I cure mice of various cancers with various therapeutics all the time. I've made mice lose more weight in a month than tirzepatide does in a year. What is hard and expensive is proving its BOTH safe AND effective **in a randomized and controlled study in humans** while ALSO manufacturing it at clinical scale and grade. I am happy for this man and his dog. It is impressive. But y'all are overhyping it.

















