TweetALS

1/5 Why are motoneurons in the spinal cord selectively vulnerable to neurodegenerative diseases like ALS? In our new work we created a single cell atlas of the human spinal cord and used it to discover underlying cell type susceptibility. biorxiv.org/content/10.110…

Congrats to some of my fave neurodegen labs (Gitler, Petrucelli, @ShorterLab, @schmidt_lab) for their clever "nuclei sorting"-informed work on how TDP43 loss drives ALS: nature.com/articles/s4158… ...Accompanying paper uses KD to reach similar conclusions: nature.com/articles/s4158…

FYI Looking for new pathways to explore to develop strategies to boost muscle strength in #ALS? @ScienceTM The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging science.org/doi/10.1126/sc…

A molecular snapshot of TDP-43 filaments from ALS-FTD cases is reported -- opening the door to new avenues of development of diagnostic & treatment strategies Structure of pathological TDP-43 ... go.nature.com/3pxdg0U TDP-43 Aggregates Spiral Into View go.nature.com/3DIlvMQ

A new study @NatureGenet argues that susceptibility to neurodegeneration in #ALS is mainly driven by neuron-specific pathology and not by immune-related tissues or microglia Common and rare variant association analyses in ALS identify 15 risk loci ... go.nature.com/3m00N55

#ICYMI Could a routine brain test facilitate the evaluation of potential drugs for #ALS #MND in #ClinicalTrials by helping stratify participants, and thereby reduce #heterogeneity? @Brain1878 Resting-state EEG reveals four subphenotypes of ALS bit.ly/2ZISkez #OpenAccess

Interested in joining the Dormann lab in Mainz? We have a postdoc position available to study post-translational modifications on RNA-binding proteins... for more details see the recent call in IMB's postdoc programme imb.de/students-postd…

Looking for a link between #ALS, mitochondrial dynamics and TDP-43 pathology? MFN2 Influences Amyotrophic Lateral Sclerosis Pathology bit.ly/31mrTf6 @pulstlab #CMT2A #DrugTarget

Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective academic.oup.com/braincomms/adv… We reviewed #MND / #ALS clinical trials to understand the key challenges in finding effective treatments to slow, stop or reverse disease. (1/n)

#ICYMI Neurotoxicity in #C9orf72 #ALS occurs due to multiple mechanisms. Could you lower this neurotoxicity by just removing the expansion --- using a small molecule? Ribonuclease recruitment using a small molecule reduced c9ALS/FTD repeat expansion ... bit.ly/3nA7SZP

#SaveTheDate Targeting proteostasis in #ALS? Attend "Neurodegeneration and Proteostasis" @NYASciences March 7. Abstracts due January 7. Can tune in online. nyas.org/events/2022/ne…

#ICYMI Looking for a new approach to ID key regulators of #RANtranslation of DPRs to develop strategies to reduce neurotoxicity in C9orf72 #ALS #FTD? @naturecomms A C. elegans model of C9orf72 ALS/FTD uncovers a conserved role for eIF2D in RAN translation go.nature.com/3BUXjGH

🚨 TWO WEEKS left for #MND/#ALS researchers to apply for @mndassoc grants for Biomedical Research Projects. ⏰ Summary applications are accepted until Friday 29 October. For more information, please visit ⬇️ mndassociation.org/research/for-r…

#ICYMI Could a simple blood test help identify the first signs of familial #FTD, including #C9orf72? @Brain1878 A data-driven disease progression model of fluid biomarkers in genetic #FTD bit.ly/3BH4eDv

Could #TBK1 be a key therapeutic target for people with #ALS and #FTD with reduced TBK1 activity? @EgganLab Loss of TBK1 activity leads to TDP-43 proteinopathy through lysosomal dysfunction in human motor neurons biorxiv.org/content/10.110…

People have long thought that astrocytes release something that kills neurons, which could partly explain why neurons die in injury/neurodegenerative disease. In a paper that just came out, we think we found one of these long-sought toxic factors! (1/8) go.nature.com/3afi6si

#ICYMI Could a potential cancer treatment strategy also be of benefit in #C9orf72 #ALS #FTD? The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity @LamitinaLab pnas.org/content/118/40…

Are you using AAV to deliver genes to the nervous system? Good news / bad news. biorxiv.org/cgi/content/sh… First the bad news: we found AAV can shrink dendrites and disrupt synaptic transmission. The good news? We figured out why it happens, and can tell you how to avoid it. (1/n)

The key to classifying clinical subtypes of #FTD may be the structure of TDP-43 aggregates Could the same be true for tauopathies? Structural strains of tau protein classify diseases go.nature.com/3mchVUr NB TDP-43 shapeshifts to encipher FTD severity go.nature.com/3ilZiw2

FYI Could the endo-lysosomal system play a more general role in neurodegenerative diseases, including #ALS? #GBA #AD #PD @JNNP_BMJ GBA variants influence cognitive status in ALS bit.ly/3ihYEQc