DrewDudleyLab

Components of normal tissue architecture maintain structure (+ fxn) & serve as barriers to tumor progression…but how? We report a 🧩 in our new preprint. Congrats to 1st author @kathrinaonate & thx to collabs @MSKCancerCenter @OHSUKnight @StanfordMed! 1/ biorxiv.org/content/10.110…

12/ HUGE shout out to our incredible team led by @KWhately @snisitha Lincy Edatt @Sonal__2405 👏 Fantastic collaborators @DrewDudleyLab @AmelioLab Appreciate the reviewers' efforts and the editorial staff at @JCI_insight who were great! @LC_Initiative_ @NCICancerBio @lcrf_org

Reprogramming endothelial cells to empower cancer immunotherapy - check out the opinion article from @Penn Abigail H. Cleveland & Yi Fan in @TrendsMolecMed #AAI2024 hubs.li/Q02vSy9Q0

@MeleroMartinLab @Nature Amazing and important work! Can’t wait to read it, my friend.

Our latest @Nature paper is out! We show that transplanting mitochondria into endothelial cells boosts their ability to form blood vessels in ischemic tissues, with mitophagy as the key mechanism. A potential game-changer for vascular cell therapies. nature.com/articles/s4158…

More evidence that the liver & pancreas are in active communication in the setting of #PancreaticCancer. There is published data already on how the primary pancreatic cancer alters the pre-metastatic niche in the liver (see next tweet). But how does the liver clap back? Nice study by Meredith Stone (now faculty with @LabBeatty) in @NatImmunol on the immune suppressive effects of hepatocyte alterations on the primary cancer tumor microenvironment (TME). nature.com/articles/s4159…

nature.com/articles/s4146… Our most recent study on resistance to ICB in melanoma is out now @NatureComms ! Great collab. with @CCITdk @DoniaMarco @TheYuanLab @KPietraslab . @medfak_LU @Lundsuni @Cancerfonden @KAWstiftelsen

New resource report in the January 15th issue— Integration of #PanCancer #SingleCell and Spatial Transcriptomics Reveals Stromal Cell Features and Therapeutic Targets in Tumor Microenvironment, by Yanhua Du et al. bit.ly/3S8d3j5

It has been a long journey but our perspective "Linking cell mechanical memory and cancer metastasis" is finally out! Many thanks to my co-authors, my mentor @RogerDKamm1, and the incredible team of @NatureRevCancer for contributing to bringing this article to light.

My emotional COI here is taller than the Burj Khalifa. With that disclosure: nature.com/articles/s4158… behold beautiful work by the brilliant @JRo_Hamilton @doudna_lab @igisci on what I personally think will be THE paradigm for immune system genome editing for both oncology and other disease indications.

Thanks for including me on this wonderful paper @lab_marine, examining the melanoma cell states that confer intrinsic resistance to immunotherapies. sciencedirect.com/science/articl… @CellCellPress @yalederm @YaleMed

While not adequately acknowledged, the dysregulated extracellular matrix plays a pivotal role in cancer. Here's a new, brilliant review on it @ScienceTM science.org/doi/10.1126/sc… w/ great @ScienceVisuals

Nice work from our recent MD/PhD student who shows how melanoma cells travel along blood vessels within the brain microenvironment. Congrats to Sarah! nature.com/articles/s4141…

New #OpenAccess @trendscancer review from @ErezNeta @LMonteran @YaelZait It’s all about the base: stromal cells are central orchestrators of metastasis cell.com/trends/cancer/… The trinity of fibroblasts, osteoblasts and astrocytes play pivotal roles in each step of the metastatic cascade in their respective organ sites. This review summarizes them wonderfully - pay special attention to the tables that highlights the evidence for each of the steps of the metastatic process (including therapy resistance) across different tumors subdivided by the three host cell types.

Temporal genomic analysis of melanoma rejection identifies regulators of tumor immune evasion biorxiv.org/cgi/content/sh… #biorxiv_cancer

'Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction' nature.com/articles/s4146…

Computational immunogenomic approaches to predict response to cancer immunotherapies nature.com/articles/s4157…

ICYMI: Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors by @HeleneSalmon featuring #TumourLandscape23 speaker @MiriamMerad-out in @CD_AACR doi.org/10.1158/2159-8…

High-dimensional deconstruction of pancreatic cancer identifies tumor microenvironmental and developmental stemness features that predict survival nature.com/articles/s4169…

Our new #preprint is out on #bioRxiv! Applying #spatial transcriptomics at subcellular resolution to 95 ovarian #cancer tumors, followed by high content #CRISPR screens, we identified immune evasion drivers at the genetic, cellular, and tissue level doi.org/10.1101/2023.1… (1/13)