Abhishek Chatterjee
1.1K posts
Abhishek Chatterjee
@AChemSynBio
Scientist, Entrepreneur, Dad, Teacher, Mentor. Tweets are personal opinions. https://t.co/aabd7QsTfk
Boston 加入时间 Kasım 2013
659 关注1.9K 粉丝
Abhishek Chatterjee 已转推
Co-Translational Incorporation of (R)- and (S)-β2-Hydroxyacids In Vivo: Directed Evolution of Efficient Aminoacyl-tRNA Synthetases | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
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Great progress toward ribosomally making a synthetic polymer, by @AChemSynBio! Congratulations!
Abhishek Chatterjee@AChemSynBio
Chintan's @cpsoni_74 work demonstrating the efficient incorporation of non-α-amino acid backbones into proteins expressed in both E. coli and mammalian cells, just came out! A great collaborative effort from @cgem_cci! pubs.acs.org/doi/10.1021/ja…
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An accompanying paper from @AlannaSchepartz and Jamie Cate groups shows how the E. coli ribosome supports the incorporation of the non-α-amino acid monomers pubs.acs.org/doi/10.1021/ja…
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Chintan's @cpsoni_74 work demonstrating the efficient incorporation of non-α-amino acid backbones into proteins expressed in both E. coli and mammalian cells, just came out! A great collaborative effort from @cgem_cci! pubs.acs.org/doi/10.1021/ja…
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Super cool work! I can see so many applications!!! Congratulations 🎉
Abhishek Chatterjee@AChemSynBio
Starting 2026 with Quan Pham's paper expanding the chemical toolbox for engineering AAV - New bioorthogonal labeling, including IEDDA, for efficient macromolecule attachment - Incorporation of two different chemistries for dual capsid labeling & much more: onlinelibrary.wiley.com/doi/full/10.10…
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Starting 2026 with Quan Pham's paper expanding the chemical toolbox for engineering AAV
- New bioorthogonal labeling, including IEDDA, for efficient macromolecule attachment
- Incorporation of two different chemistries for dual capsid labeling & much more:
onlinelibrary.wiley.com/doi/full/10.10…
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Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by @conor_loynd, @SinghaSoumya, and @SCanarelli! We introduce a new generation of BONCAT tools for versatile characterization of newly synthesized proteins in pathogenic bacteria rdcu.be/eI4M5
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Abhishek Chatterjee 已转推
A facile chemical strategy to synthesize precise AAV-protein conjugates for targeted gene delivery dlvr.it/TMfgwR
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Cool work from @Han_Xiao2016 on site-specific incorporation of an environment-sensitive fluorescent noncanonical amino acid to visualize protein microenvironment changes in living cells
Nature Chemical Biology@nchembio
Genetically incorporating environment-sensitive noncanonical amino acids containing rotor-based fluorophores to target proteins enables real-time visualization of microenvironment changes in protein substructures nature.com/articles/s4158…
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pubs.acs.org/doi/10.1021/ac…
Very proud of this effort by the group! Here we explore how and why the reaction kinetics of covalent drugs can be enhanced by the target binding site itself and reveal enhancement is likely coupled to electrophile reaction mechanism.
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It took 7.5 years, but my first lab project is officially out! We develop an approach to identify the liver nascent proteome, especially membrane proteins, under various pathophysiological conditions, revealing key regulators involved in hepatic steatosis. nature.com/articles/s4146…
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Our work @cgem_cci on co-translational incorporation of a noncanonical monomer into a protein, followed by its triggered post-translational chemical rearrangement, yielding novel backbone modifications. nature.com/articles/s4158…
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Abhishek Chatterjee 已转推
Happy to see this new T7 replicon based orthogonal replication system in E. coli. Congrats to the Diercks and Schultz lab teams at Scripps Research! science.org/doi/10.1126/sc…
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My promotion and #tenure is now official @JohnsHopkins. Just feeling really happy and grateful for my students, colleagues, family, and friends. You've made the last 7 years in #Baltimore some of the best in my life! 😁
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Abhishek Chatterjee 已转推
I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @AmanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share!
youtube.com/watch?v=8YhJM6…
YouTube
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Abhishek Chatterjee 已转推
Today in @ScienceMagazine we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells, a collaboration with @SternbergLab.
1/13
drive.google.com/file/d/1I-UbCR…
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Abhishek Chatterjee 已转推
Writing in @J_A_C_S, we report a sugar-derived single-addition monomer that can be added together with other monomers in #ROMP and install functional groups at the chain end of metathesis polymers. #glycotime #polymer #NSFfunded
pubs.acs.org/doi/10.1021/ja…
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@ozalabCP @StanfordChild Wishing her a speedy recovery!
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A really neat read while I wait bedside @StanfordChild for my daughter to receive a heart ♥️ transplant. Seeing the active research in the field is a great source of hope.
Krishnaswamy Lab@KrishnaswamyLab
(1/n) I’m excited to share work tackling problem of time-to-death prediction after circulatory death (DCD) using a neural ODE/RNN framework. Lead by @XingzhiSun @EdwardOnBrew @ChenLiu_1996 , in collaboration with @RameshkBatra of @YaleMedicine! nature.com/articles/s4159…
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