JAY

Neuro-technology redefining spinal cord injury rehabilitation. At Walk Again Rehab, the world’s only brain-controlled exoskeleton restores brain–body communication, helping individuals with #SpinalCordInjury regain voluntary movement, improve mobility, and rebuild functional independence beyond conventional therapy. 📩 DM us or email inquiry@walkagainrehab.com #SpinalCordInjury #NeuroRobotics #NeuroRehab #WalkAgainRehab #NeuroTech Cc: @spinalinjuries @backuptrust @NeuroRehabSci @teachplaygrub @lifeafterpara

@thegarybrecka the hardest one is usually the one that matters most

Which one is harder for you to fix right now? A) Sleep schedule B) Nutrition C) Stress Your answer usually points to your biggest leverage point.

@ChrisWillx peace gets louder when the noise goes quiet

Avoided all news for a month in Australia. Highly recommended.

@davidasinclair @nvidia aging might become optional before we’re ready for it

It also required massive-scale AI infrastructure from @NVIDIA This pre-print is a sign that the future of aging research will be guided by the intersection of biology and machine intelligence Soon, we won’t just measure aging, we’ll control it

New paper @GladstoneInst @UCBerkeley @nvidia reinforces the Information Theory of Aging (ITOA). Looking at 175M single-cell gene expression patterns, AI found cells lose their identity over time. The model then predicted how to restore lost information to rejuvenate cells…🧵

@hyderabaddoctor people call it harmless until the long term shows up

Science of Staying Well Think a drink is harmless? Here’s what it does to your body Experts warn that there is no safe level of alcohol, and reducing consumption can significantly improve individual and public health outcomes Read my latest weekly column published in The WEEK theweek.in/news/health/20… @tisha_jaco @TheWeekLive

@BrandonLuuMD skipping proven treatment is a risk you can’t undo

For breast cancer, alternative medicine alone was linked to a 267% higher mortality hazard. Even when combined with standard treatment, mortality hazard was still 45% higher. Modern oncology saves lives. Please consider using it.

@newstart_2024 most problems aren’t random we just treat symptoms not causes

“There’s no such thing as essential hypertension.” Dr. Pradip Jamnadas just dropped a truth bomb most doctors still won’t say out loud. High blood pressure is rarely random. One of the biggest hidden causes is chronically elevated insulin. When insulin stays high, your blood vessels can’t relax and dilate properly, so pressure skyrockets. Lower the insulin through fasting and simple dietary changes, and blood pressure often normalizes — sometimes without needing lifelong medication. Sleep apnea is another common culprit. It’s a powerful reminder that many “chronic” conditions have reversible root causes. Have you (or someone you know) seen blood pressure drop dramatically after fixing diet, fasting, or sleep?

@drmarkhyman health is just consistency dressed up as discipline

You don't magically become healthy. You practice it. You notice you're making a bad choice and correct it, over and over again until the good one becomes automatic. The people who figured this out aren't special. They just decided to take it seriously one day and never stopped.

@fmfclips crazy how even receipts come with side effects now

Receipts are an overlooked source of exposure to endocrine-disrupting compounds Thermal paper receipts are coated with bisphenol A (BPA), a plastic chemical that can be absorbed through the skin during handling It might feel trivial, but repeated exposure adds up Cashiers who handle receipts regularly have very high BPA levels, and hand creams or sanitizers can increase absorption up to 100-fold If you don't need the paper copy, choose an emailed receipt instead And if you handle receipts for work, nitrile gloves (not latex) can help reduce exposure Small, consistent habits like this can reduce your total chemical burden more than you might think

@ShiningScience future medicine really said let’s just freeze the problem away

Australia has unveiled a groundbreaking MRI-based technology that can freeze tumors and ease pain—without the need for surgery. This advanced method uses cryoablation to precisely target and destroy tumor cells by freezing them, offering a powerful non-invasive alternative to traditional treatments. By combining real-time MRI imaging with targeted cryotherapy, doctors can treat tumors with exceptional accuracy while protecting healthy surrounding tissue. This makes it especially valuable for patients who cannot undergo surgery or want to avoid lengthy recovery times and surgical risks. Beyond shrinking tumors, this innovation significantly reduces pain, lowers complications, and allows for faster healing. It represents a major leap forward in cancer care, giving patients safer and more comfortable treatment options. As this technology expands, it could reshape how cancer is treated worldwide—making care more accessible, efficient, and less invasive. Could this be the future of cancer treatment without surgery?

@siimland tea and coffee teaming up like the ultimate productivity duo

Theanine and caffeine work better for cognition than either one alone🍵☕ The combination of theanine 🍵(97 mg) and caffeine ☕(40 mg) improves cognitive performance and subjective alertness compared to placebo (PMID: 21040626). A 2021 review saw that theanine alone has mild cognitive benefits but potentially worsens inhibitory control. Whereas caffeine has a strong effect on attention and processing speed, but increases mental fatigue and worsens impulsivity (PMID: 35111479) Full video on theanine: youtu.be/PaT-sg_PjnM

@EricTopol @NatureMedicine @NatMentHealth science catching up to what people have been saying for years

Two systematic, meta-analyses on psychedelic drugs today Brain Circuit Function @NatureMedicine nature.com/articles/s4159… Depression @NatMentHealth nature.com/articles/s4422…

@drwilliamwallac wild how something so small can quietly do that much damage

B12 maintains myelin through two separate pathways. Both fail at the same time when B12 drops. Pathway one: B12 converts homocysteine into methionine, which becomes SAMe. SAMe builds the lipid components myelin is made of. No B12, no SAMe, lipid synthesis stalls. Pathway two: B12 clears a metabolic byproduct called methylmalonic acid. Without it, abnormal fatty acids get incorporated into the myelin sheath itself. The structure degrades from the inside. Here is what makes this dangerous. In the Lindenbaum 1988 NEJM study, 28% of patients with neuropsychiatric symptoms from B12 deficiency had completely normal blood counts. No anemia. No macrocytosis. The myelin was already degrading with nothing on the CBC to flag it. Caught early, repletion can reverse it. Caught late, the demyelination can be permanent. A normal B12 blood test does not rule this out. MMA is the more sensitive marker. Scalabrino, Prog Neurobiol, 2009. Lindenbaum et al., NEJM, 1988.

@bryan_johnson bro turned sweating into a full time research project

If you’re wondering how I initially landed at 20 minutes at 200°F for a daily dry sauna, this protocol is supported by both large observational longitudinal cohorts and smaller interventional studies. These studies demonstrate significant benefits for longevity and healthspan, including reduced mortality and morbidity from all-cause and chronic diseases. Observational evidence suggests that using a dry sauna 4 to 7 times per week for more than 19 minutes per session at temperatures between 176F and 212F provides the highest level of health benefits. Here are some examples of the benefits (using comparable protocols to mine): > 14-40% reduction in all-cause mortality in middle aged men > 48-70% long-term reduction in fatal heart disease in both women and men > 47% Reduction in the risk of developing a high blood pressure in healthy men > 31% average reduction in hsCRP in healthy middle aged men. > 40% Long term sauna use was correlated with decreased all-cause mortality > 48% reduction in dementia risk. > Slightly improved well being, 83% reported better sleep, and 77% less risk of psychotic disorders. Important points to keep in mind While most dry sauna studies do not identify heat-shock response including HSPs, the ones that do only give directional hints of HSPs secretion, to our awareness intracellular expression of HSPs has not been addressed with dry and why I decided to start quantifying my heat shock protein secretion and expression myself. While HSPs are a major driver of sauna benefits, other mechanisms including increased cardiac output and blood flow (exercise mimetic), vascular remodelling and adaptation, as well as sweating all contribute to the benefits.  A strong hit at this are the smaller yet significant benefits observed even with shorter durations and lower frequencies (10–19 minutes, 2–3 times per week), conditions very unlikely to achieve any measurable heat shock protein response. Therefore, do not be discouraged if you aren't ready for the long sessions required for measurable HSP activation. Real health benefits begin with just 10 minutes at 176°F, twice a week. If you are just starting your sauna protocol, remember that reaching longer sessions (over 33 minutes) at extreme heat of 190°F or above requires time. Listen to your body, and progress gradually and be careful not to exceed your personal heat tolerance limits. Also, stay hydrated and if you’re a man, ice your boys. My benefits from my starting protocol were real and persistent over 232 sessions including > 10+ years reduction of my vascular age and functional improvement (central pressure markers showing increased vascular elasticity and compliance) > Full detoxification of 3 out of 6 environmental toxins, remaining 3 were slashed by 55% to 65%, one toxin was reduced by only 15% and persisted at a slightly elevated level (with 15 sessions only). > Elimination of 85% microplastics from my blood and semen > Fertility markers at all time high (count, motility, and morphology) in 24 iced sessions.

I think I need to be fired. I've done 232 dry sauna sessions. Last week I confirmed, for the first time (by swallowing a pill), whether the core temperature threshold that gates the primary cellular repair mechanism was actually being reached in my protocol. The threshold is 102.2°F (39.0°C). For me, that takes 33 min at 195°F. With ice on face and neck, 38min. My standard daily protocol was 20 minutes. That wasn’t enough time to get my core body temp to the heat shock threshold of 102.2°F (39.0°C). Causing me to ask, did I just waste 77 hours and 20 min? It's possible my heat threshold has increased and the heat shock protein release was happening previously, but I doubt it based upon the subjective feeling I now understand as being 102.2F (39.0°C). It’s brutal. For these 232 sessions, I measured the temperature of the air, humidity, duration, frequency, the sweat output, blood biomarkers, vascular response, toxin clearance and fertility markers. There is no human body in history that has been more measured in sauna than mine. Nevertheless, I did not confirm the one number that determines whether the primary mechanism was activating. My goal wasn't to be a sauna bro. It was to saunamaxx. I was doing the former while thinking I was doing the latter. I rest my case. I should probably be fired.

A ruthless rule: your worth is not allowed to fluctuate with your output. On low‑function days it’s tempting to think, “I didn’t get anything done, so what’s the point of me?”, but that’s just capitalism and old wounds cosplaying as truth. You are not a cancelled project because you rested, replied late, or dropped a ball. When that story kicks in, anchor to one small, concrete act of care instead of chasing a huge comeback: drink a glass of water, eat something simple, take meds, text “I’m alive, just low” to someone safe. Those moves don’t look dramatic from the outside, but they’re how you slowly teach your brain that being alive is not a performance review.

If your brain keeps revisiting the same memory like it’s trying to “solve” it, that doesn’t mean you’re obsessed, it often means your nervous system never got to finish the story. Maybe you had to stay calm, be the strong one, or pretend you were fine, so the feelings got paused but never processed. When that scene replays now, instead of asking “Why am I still not over this?”, try asking “What did I need back then that I never got to feel or say?” Sometimes the next step isn’t another mindset shift, it’s giving that past version of you a safer place, therapy, journaling, a trusted person, to finally be as angry, sad, scared, or disappointed as they weren’t allowed to be the first time.

If your brain keeps revisiting the same memory like it’s trying to “solve” it, that doesn’t mean you’re obsessed, it often means your nervous system never got to finish the story. Maybe you had to stay calm, be the strong one, or pretend you were fine, so the feelings got paused but never processed. When that scene replays now, instead of asking “Why am I still not over this?”, try asking “What did I need back then that I never got to feel or say?” Sometimes the next step isn’t another mindset shift, it’s giving that past version of you a safer place, therapy, journaling, a trusted person, to finally be as angry, sad, scared, or disappointed as they weren’t allowed to be the first time.

The most powerful don’t‑die skill is not discipline, it’s interruption. You don’t have to fix your whole life tonight; you just have to interrupt one chain reaction your brain usually runs on autopilot. Maybe it’s the “bad day → skip food → doomscroll → 3 a.m. bedtime” script, or the “lonely → text the person who wrecks me → feel worse” script. Pick one point in that sequence and swap in a tiny, less‑self‑destructive move: order a simple meal, step outside for five minutes, message a safe friend, put your phone in another room while you shower. You might still feel awful, that’s okay. What matters is that you proved, even for one night, that the story doesn’t have to end the old way. Every interrupted spiral is a small survival rep, and those reps add up.

Post‑stroke fatigue isn’t “just being tired,” it’s a real condition where up to half of survivors feel a constant lack of physical and mental energy that makes even basic tasks exhausting. Studies show this fatigue is tightly linked with mood, anxiety, and quality of life, and it can slow down rehab because it’s harder to focus, practice exercises, or stay motivated when your body and brain feel wiped out. If this is you, you’re not lazy or weak, fatigue after stroke is common and treatable, and it deserves the same kind of attention as blood pressure, mobility, or speech in your recovery plan.

Satiety is biology, not just a discipline. Science shows protein, fiber & hormones like GLP-1 control how full you feel—directly impacting fat loss and metabolism. Control hunger → control results. #Fitness pubmed.ncbi.nlm.nih.gov/40524526/

You are one walk away from a better day.