Burhan

Just received concerning data coming soon from UCLA and Mount Sinai clinicians about lymphopenia, covid and breast cancer metastases. Sadly our concerns of the increasing incidence of metastatic disease and recurrences of patients in remission following Covid and worse with lymphopenia is being validated. Data soon at AACR this month.

The androgen backdoor synthesis pathway was only recently discovered and acknowledge to be important in humans Progesterone ->>>> DHT The fact that a pathway exists that takes progesterone to androsterone/DHT should not be ignored, especially when this pathway likely falters BEFORE the main delta4/delta5 testosterone synthesis pathway, and great influences regulation of the hypothalamus-pit-gonadal axis and the hypo-pit-adrenal axis. Adrenal steriodogenesis alterations (adrenopause) predate gonadal alterations (andropause) What happens in to your adrenals in 30s/40s is what leads to the hypgonadism of your 50s. A perfectly timed clock. For some, that clock starts earlier, and they are hypogonadal by early 30s. But zoom out even more. This starts with your pineal gland/circadian rhythmicity in your teens/20s. In the elegant and beautiful endocrine system: adrenals regulate testicles, which makes too much sense given that high stress states should decrease fecundity What’s the main serum marker of testicular testosteorne production and fertility? 17OH progesterone My endocrinology textbooks still don’t highlight this key pathway, and the idea that progesterone can become DHT is mind blowing to many There is no strong scientific evidence to the claim “DHT is not needed after puberty” and it suffers from the same hubris as “thymus doesn’t matter in adulthood”. Sure, many men can tolerate 5AR inhibitors like finasteride, but that doesn’t prove that DHT isn’t important. These drugs aren’t able to fully lower DHT in the cell, and they may have compensatory upregulation of androgen receptors. Humans are resilient Key point: male pattern hair loss is a disorder caused by aberrant upregulation of 5AR in scalp, not a disorder of systemic DHT excess. Treatments should focus on figuring out why 5AR is upregulated and address that, or use local inhibition of the 5AR enzyme in those prone to MPD And if you take a guy from a serum DHT of 25 to a serum DHT of 5… how much are you really changing Endocrinology needs some androgen infusions. It’s getting stale and decrepit More to come

Monster paper on redlight and mitochondria from Hamblin. Key takeaway: Red/near-infrared light kicks nitric oxide off cytochrome c oxidase → massive ATP boost + beneficial ROS signaling for repair, less inflammation, and stem cell generation. Blue light from screens and windows and leds? Linear ROS explosion, tanked energy and circadian chaos via melanopsin dysregulation. Suggested action steps: • 10–20 min red light therapy daily = exercise mimetic for your cells • Block blue light after sunset (your mitochondria will thank you) • Low & slow doses win and high doses could backfire. REMEMBER. Your cells aren’t just powered by food. They are powered by LIGHT too. See my favorite red lights and blue blockers below.

Prediction: the peptides that will hit the broader male and female HRT space next are kisspeptin and gonadorelin (and not in place of HCG!). Will be interesting to see which companies compound for wide distribution first. These are potent and MD monitoring will be key.

Scientists may have found proof that hydrogen water reverses what doctors call "inevitable" cellular aging. A 6-month study showed telomeres — the biological clock inside every cell — actually grew. People drinking regular water? Theirs shrank. Here's the breakdown:

I just want to scale cheap, affordable health for people. With AI will be able to do this That’s the focus for next few months. Here we go. We can make more money selling $200 supplements. But there’s a protocol for someone who can spend $10 and also for $10 k a month

Ok there’s something here N=1 update Stopped it for 3-4 days while still fasting and appetite returned to normal Then resumed the UV and felt a glp-1-lite effect There are GLP-1 receptors on POMC neurons… hmmm This requires further testing and investigation

The biggest energy shifter for me lately is the $9 thiamine bottle I bought on Amazon Not some fancy thiamine Just dirty cheap thiamine HCL At some hefty doses. 3-600+mg BID Honestly better than Mot-c, SS-31, NAD+ lol High carb + b1

Based on this newly published Nature study. Thymus bioregulators become a lot more interesting. Nature found that adult thymus health tracks with mortality, cardiovascular disease, inflammation, and metabolic health. And there is already human Thymalin data pointing in that direction from 2003. In a 6–8 year study of 266 elderly patients: - acute respiratory disease incidence was about 50–58% lower - mortality was about 50–52% lower with Thymalin alone - mortality was about 60% lower with Thymalin + Epithalamin

pine + epi is one of the most synergistic combinations that exists imo, on par with armodafinil + bromantane but for longevity, sleep, and cognitive health; armodafinil keeps dopamine in the synapse longer, bromantane increases your brain's ability to produce dopamine pinealon optimizes sleep architecture, epitalon optimizes circadian rhythm (goes way beyond just sleep) 6 hours recovering like 9. no grog. consistent energy, deep sleep one stack handles the output, one stack handles the recovery. run all 4 and you're lapping 99% and this is without even mentioning the rest of the benefits & synergy in between pinealon and epitalon. together they cover; - brain fog - neuroprotection - memory - stress resilience - focus - serotonin regulation - telomere lengthening - cortisol regulation - cellular longevity not medical advice. pinealon: yourprotocol.co/products/pinea… epitalon: yourprotocol.co/products/epita… subq for the masochists: pinealon: swisschems.is/product/pineal… epitalon: swisschems.is/product/epital…

Pewdiepie reveals how to break free from the algorithm “A lot of this is going to sound crazy but you’ve gotta hear me out, it’s a step by step process. I’m not saying you should do all of it but you should try some of it” “Step 1 is creating friction. I put all social media and attention hungry apps in a second profile and I can’t understate how much this changed my life. Those 5-6 seconds it takes to switch profiles stops me every time and makes me think, is this what I want to be doing?” “The second thing I did was self hosting. The effect that had on me is I’m not the product anymore. The things I use are mine and because they’re not free, I’m not paying with my privacy. I think the main difference is ads and news don’t reach me” “Next thing I did was disable Shorts, I like YouTube but I hate how Shorts is everywhere I can’t escape it” “Then I unfollowed everyone. You don’t have to do this, this is definitely a me thing, I just got really fed up” “Next, get a DNS blocker. You can remove ads completely, most of it won’t even reach your device” “I think you owe it to yourself to take some time today and start building your tech fence” “These tech companies don’t care about you, so you’ve got to care about yourself. The cheat code is building some friction and filtering out the noise, that’s your defence and your cure”

Glycine works for sleep but doesn't work like a typical "sleep supplement." It works like a thermostat. When you take 3g of glycine before bed, it crosses the blood-brain barrier and binds to NMDA receptors in the suprachiasmatic nucleus, the brain's master circadian clock. This activates the medial preoptic area, which triggers peripheral vasodilation: blood flow increases to your hands and feet, heat radiates out through the skin, and your core body temperature drops. That temperature drop is the same signal your body produces naturally before sleep onset. Glycine just makes it happen more reliably. This was mapped at Stanford by Kawai and colleagues. When they ablated the SCN in animal models, glycine's sleep-promoting and hypothermic effects disappeared entirely, confirming this is the target, not a downstream side effect. In human trials, 3g before bed reduced sleep-onset latency and next-day fatigue in volunteers with sleep complaints. Polysomnographic data showed improved subjective sleep quality correlated with the temperature shift. The practical detail nobody mentions: glycine is one of the cheapest amino acids on the market. A 3g dose costs roughly nine cents. It has no sedative hangover because it isn't a sedative. It works through the same thermoregulatory cascade that a hot bath before bed exploits, peripheral vasodilation leading to core cooling, except it initiates it centrally rather than peripherally. *None of this means glycine replaces sleep hygiene or addresses underlying sleep disorders. . Kawai et al., Neuropsychopharmacology, 2015 Bannai et al., Frontiers in Neurology, 2012 Yamadera et al., Sleep and Biological Rhythms, 2007

Big implications, folks, for today's new reports on the thymus gland and healthspan —Our thymus gland largely involutes after the teenage years, but AI used to determine its persistent level of health —Healthy adult thymus linked to an array of remarkably improved health outcomes in 2 cohorts —Cardiovascular incidence and mortality reduced (Figure); also less all-cause mortality —Pulmonary mortality, digestive disease, metabolic disease mortality reduced (Figure) —Reduced inflammation; reduced lung cancer; improved metabolic markers nature.com/articles/s4158…

The remarkable benefits of 5 min per day of meditation. Which is simply, sitting quietly and observing your own thoughts, stress, etc. not clearing the mind etc. As explained by @RichieJDavidson on the Huberman Lab podcast out now.

❌ Using peptides, hormones, drugs for “more energy” ✅ Using all available and indicated modalities to get more high quality sleep and recovery -> more energy Exogenous compounds need to work to support your existing protocols Light, supps, peptides, hormones

Andrew Huberman drops raw truth on self-mastery: The biggest mistake most people make is hunting for the external fix—caffeine, activities, new routines—while the real power to change everything lives inside. “You realize the ability to withhold reflexes you don’t want—like getting your temper sparked, not speaking from your first thought but your second or third—all of that comes from internal work.” He admits he spent years chasing outside solutions before seeing the pattern: Thoughts layer like embers in a fire—you can feed them or starve them. Rumination on something painful? Distraction is often the smarter move unless you’re deliberately processing it. The brain is wild with input—stopping, listening, and going “wow, my mind is crazy” is where the shift starts. Clip from this 1:35 clip—pure neuroscience-meets-wisdom gold. The most powerful upgrade isn’t something you add... it’s something you learn to not do. What’s one reflex or thought pattern you’ve started catching and starving instead of feeding? Your wins (or ongoing battles)—drop them below.

This is wild. 143 million people thought they were catching Pokémon. They were actually building one of the largest real-world visual datasets in AI history. Niantic just disclosed that photos and AR scans collected through Pokémon Go have produced a dataset of over 30 billion real-world images. The company is now using that data to power visual navigation AI for delivery robots. Players didn't just walk around with their phones. They scanned landmarks, storefronts, parks, and sidewalks from every angle, at every time of day, in lighting and weather conditions that staged photography would never capture. They documented the physical world at a scale no mapping company with a fleet of vehicles could have replicated on the same timeline or budget. Niantic collected this systematically, data point by data point, across eight years, while users thought the only thing at stake was catching a rare Charizard. The most valuable AI training datasets in the world aren't being assembled in data centers. They're being built by people who have no idea they're building them.

Dr. Patrick Soon-Shiong unearths a 20 year old report in front of NIH Director Dr. Jay Bhattacharya Scientific leaders identified the most important molecule to stimulate the production of T Cells and NK Cells, which are “the most important cell in your body to kill cancer”. SOON-SHIONG - “Thought leaders of the country have known for close to 20 years”.

The new Huberman Lab episode is out: Unlearn Negative Thoughts & Behaviors Patterns | Dr. Alok Kanojia (@HealthyGamerGG) 0:00 Alok Kanojia (Dr. K) 3:09 Internet, Computer Games; Academic Pressure 7:11 Millennials & Self-Awareness, Hijacking Mental Health Language 13:24 Sponsors: Lingo & Joovv 16:06 Personality & Individual Road Maps, Misdiagnosis 22:02 Ambiguity, Flirting, Social Skills Decline, Uncertainty Tolerance 26:06 Dating in the Internet Age, Cognitive Bias 30:39 Healthy Distress Tolerance, Tool: How to Feel Your Feelings 39:58 Sponsor: AG1 40:49 Expectations vs Internal Desire Roadmap, Western vs Eastern Theory of Mind, Ego 50:35 Sense Organs, Comparison & Proving Oneself, Internal Drive 59:22 Internet, Ego, "Teflon Buddha", Tool: Dealing with Criticism 1:10:36 Observing One's Mind, Meditation, Psychedelics 1:11:59 Sponsor: Function 1:13:46 Tool: Shunya "Void" Meditation & Resilience 1:24:02 External Reminders, Environment; Men & Emotional Regulation 1:30:04 Samskara, Yoga Nidra, Trauma & Learning, Shunya & Personal Compass 1:39:15 Yoga Nidra, Channeling Divinity, Genius 1:42:30 Sponsor: Eight Sleep 1:43:48 Breathwork Practices; Meditation Science, Self-Esteem & Belief Change 1:53:40 Liminal States, Meditation Types & Benefits; Western & Eastern Balance 2:01:50 Understanding Ego & Perception; AI & Narcissism, Psychosis 2:14:07 Tool: Healthy Social Media Use, When To Not Use, Normal Standards 2:18:38 Social Media & Looks Obsession, Purpose, Charisma 2:24:18 Young Men Falling Behind?, Male Support, Suicide; Men in Relationships 2:30:36 "Stuck" Young Men, Failure to Launch, Tool: Motivation & Understanding Oneself 2:39:03 Pornography, Erectile Dysfunction, Emotions, Addiction; Relationships 2:44:21 Men & Love, Looksmaxxing, Rejection, Partner Characteristics, Tool: Walk Before Dates 2:55:12 Exploring Practices, Meditation, Breathwork 3:01:39 Spirituality, Personal Exploration; Acknowledgements 3:06:12 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Includes paid partnerships.

Internal medicine skill set didn’t fail me and serves well even if it’s about peptides When diagnosing a patient I run through this pneumonic, and always focus on the second I: iatrogenic A lot of patients problems are from the meds, supps, peptides that they misused