Christopher Benassi

Great visual from @julesyoo @a16z with the juxtaposition of US food and medical costs as a % of GDP - showing a virtual swap between the two expenditures 1960 *Food: ~14% *HC: ~5% Today: *Food: ~8% *HC: ~18%

@tbpn @MartinShkreli @maxmarchione amazing

THE GREAT PEPTIDE DEBATE: FULL DISCUSSION Peptide bear @MartinShkreli squared off against peptide bull @maxmarchione today in a back and forth on retatrutide, BPC-157, randomized controlled trials, the FDA, the pharmaceutical industry, and more. 00:00 Opening arguments 06:08 Martin on the downsides of retatrutide 10:24 Back and forth on BPC-157 14:41 Randomized controlled trials — issues and benefits 19:19 Max on the potential of Thymosin Alpha-1 23:21 Martin on why peptides should be controlled substances 26:07 The FDA's strengths and weaknesses 29:05 Closing arguments

@ttunguz @nikillinit open source. open source. surprised I was first to tag you

It’s not easy to replicate Cursor’s innovation on US models. American open-source frontier models average 8 months old. Chinese open-source models average 7 weeks. That’s a 5x age gap. Cursor chose Kimi K2.5 (8 weeks old) over GPT-OSS (8 months old) for good reason : in AI, eight months is three generations of models. Meta, formerly America’s open-source champion with Llama, pivoted to closed-source development in 2025. Chinese open-source models grew from 1.2% of global AI usage in late 2024 to nearly 30% by the end of 2025. Qwen overtook Llama in cumulative downloads by October 2025, reaching 700 million downloads on Hugging Face. But commercializing Chinese models in the US carries risks : NIST found Chinese models 12x more susceptible to agent hijacking attacks, & companies like Microsoft & News Corp have banned their use entirely. Many government agencies have followed suit. Meanwhile, the American open-source response is taking shape. NVIDIA announced a $26 billion commitment over five years to open-source AI through its Nemotron Coalition. Google, OpenAI, & the Allen Institute are building alternatives. OLMo 3 matches Qwen 3 on math benchmarks with 6x less training data. Cursor’s choice wasn’t ideological. It was practical. When the best open-source option is Chinese, that’s what a $50 billion company will use. Open source is how startups compete with giants. The next Cursor will be built on the best open-source foundation available. The question is whether that foundation will be American. tomtunguz.com/cursor-kimi-op…

@nikillinit Trure...yeah hit send and regretted it. Also, depends on fixed cost base and also if current MV ED mix/profitability. Either way - your article felt more impactful that I would have guessed

@Chris_Benassi depends on if they just increase the prices somewhere else, or make the remaining visits higher $ per visit

what do you think the impact of self-driving cars might be in healthcare? IMO the true ramifications of self-driving cars are understudied, and I think there are parts of healthcare this is going to really impact. So I thought I'd write on what some of those areas might be. What happens when there are less crashes, or the interiors of cars can change, or fleets are all electric vehicles? full post is in the next tweet

@jameygannon @clairevo @lennysan @ridd_design I'm looking for an option in May or later? Might be user error, but I don't see another option. Ready to sign up once I see it

@Chris_Benassi @clairevo @lennysan @ridd_design active right now

closing sign-ups for cohort 2 of The AI Creative Director this weekend 3 podcasts I've done recently where you can learn more about me and the process I teach in the course: How I AI w/ @clairevo - featured by @lennysan Dive Design Club w/ @ridd_design The Alchemist's Library 2/ @RyanJAyala 🔗s below

@zachpogrob Status on android? I just shed my iphone like a psycho

update on share aura android coming soon :)

@jessegenet @openclaw @pollylmcneil

My @openclaw helps me figure out the best hands on demonstrations for homeschool science, even buying props for me now 🤓 AI is still crushing custom illustrations, this time 6 types of energy ⚡️

@BobbySamuels Awesome post - thank you

@kvnwang @johnarnold 100% - can create an @AlphaSchoolATX

@johnarnold @Chris_Benassi Why not take the same time period but use that time to emphasize the first principles for medicine to prepare them for the age of AI

AI should allow med schools to rethink whether 4 years is still necessary for med school. If students can focus more on clinical practice and less on memorizing the Krebs cycle and molecular bio, many programs could eliminate a year, reducing both costs and physician shortages.

🚨: A petri dish of human brain cells just learned to play DOOM

@iamjasonlevin This is so damn true. Probably crosses my mind 1x per week since you posted

"How'd you raise $3M for meme app???" I used a tactic I call "The Cool Shit Law" I made up in 2022. The Cool Shit Law took me from broke in New Jersey to penthouses, Thiel parties, and raising $3M. Here's how it works: For 4 years, I made cool shit and reached out to cool people everyday. No expectations. Just saying hi to people I thought were cool. During that time I went from broke freelance writer to founder/VC ghostwriter to watching YouTube and becoming a founder myself. I kept on posting the whole time and people saw my journey. Then in May last year, I decided I was ready to raise. So what did I do? I didn't spray and pray, I reached out to people who I knew already got me. - Our first check came from @cyantist, one of the best angel investors of all time. We got in contact because she liked my silly videos lol. We got on the phone on a Tuesday, I flew out the next Monday and had a check by Thursday. No deck or product demo. Just a conversation. - Another one of our early checks came from @balajis, one of my long-time heroes. I first DM'd Balaji 5 years ago. I'm literally wearing a sweatshirt in my profile picture that says "Balaji was right" that I made myself. (And yes, he was right about Memelord 😉) - Another early check came from @EricJorgenson. Eric was one of my first Twitter heroes. I read The Almanack of Naval Ravikant and it changed my life and taught me about leverage. I had Eric on my podcast 3 years ago and we stayed in touch. Do cool shit, find cool people who genuinely support you. While I don't how to code, I do know how to make friends on the internet. And I believe in the age of AI, that's far more important. Follow The Cool Shit Law, my friends. It will change your life.

@nikillinit One of your best pieces IMO - dense with great info and felt very targeted

What are some cool areas in open source healthcare today? Tomorrow we're going to talk about a few specific areas in the open source healthcare movement that I find particularly interesting - Datasets - Data infrastructure and tooling - AI models and algorithms - Disease measurement - Hardware Sign up in the comments to get it when it comes out

@Charles_Y_Wu Awesome concept. Excited to see where this goes

🦞MedOS is the future of Healthcare

@AppleHelix I feel like each bio teacher felt it was their mission in life to ensure the students at least walked away w Krebs

@Chris_Benassi I think I learned the Kreb cycle no less than 5 times through out schooling. I had to memorize it again every single time

I am pretty sure 99% of people who remembers the Kreb cycle actually have to teach Kreb cycle.

This morning's BioNTech news strikes me as very odd. Certainly, founder Ugur Sahin and Ozlem Tureci shouldn't feel compelled to run the company forever, and they may not be the right people to manage both the continued decline of Covid-19 vaccine sales and the launch of new cancer drugs. And given the disastrous quarterly numbers the company posted -- a per share loss for the quarter that was triple what analysts expected, revenue guidance for the year about half a billion Euro below analyst forecasts -- there is a good argument someone else needs to be playing the game of managing expectations here. But they are also key to the identity of the company, and announcing their departure without a successor in hand feels to me like a failure of leadership that only adds uncertainty at a time when it is already high. The stock is down 18%. $BNTX Our story here, by @DrewQJoseph. statnews.com/2026/03/10/bio… via @statnews

Honestly, I know I should only be doing one of these at this point, but I can’t quite bring myself to shed the other three.

@kimberlyanngeo @talkspace @UHS_Inc Definitely unexpected! Will be intetesting to watch it play out

I didn’t see this one coming, @talkspace acquisition by @UHS_Inc. Hoping this accelerates the opportunity to improve access to behavioral health service that so many Americans need.