Pushpendra Hirapara retweetledi

Congratulations 👏 .
✨ Dr. Sudeep Gupta and team @TataMemorial deliver the first phase III trial showing OS benefit with carboplatin in TNBC (JCO 2025, n=717).
Overall (ITT population):
📈 5-yr EFS: 70.7% vs 64.1% (HR 0.80, p = 0.081)
💫 5-yr OS: 74.4% vs 66.8% (HR 0.74, p = 0.029)
⭐ pCR: 54.5% vs 40.3% (p < 0.001)
Premenopausal subgroup:
🚀 5-yr EFS: 75.0% vs 59.6% (HR 0.61, p = 0.003)
🏆 5-yr OS: 78.2% vs 64.6% (HR 0.57, p = 0.002)
In postmenopausal TNBC, carboplatin offered no additional EFS or OS benefit, underscoring the need for biology-driven rather than intensity-driven approaches in this group.
🌍 A shining example of an investigator-initiated LMIC trial — proving that world-class, practice-shaping oncology research can emerge from India. 🇮🇳
@ICMRDELHI @CRI_ACTREC
ascopubs.org/doi/10.1200/JC…
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