Collin Ewald

Thank you @VeraBohren for this wonderful portrait and interview at #69inspiringPeople. 69people.ch/en/people/dr-c…

Supplementing the three primary collagen amino acids glycine, proline, and hydroxyproline in a 3:1:1 ratio produces consistent, measurable benefits across worms, mice, and humans. In humans, skin outcomes (wrinkles, texture, elasticity, and hydration) improved 4–6% within 1–3 months. The most striking result was a reduction in biological age by an average of 1.4 years after 6 months, with maximum reductions of 8.9 years in men and 12.1 years in women. Those with a biological age higher than their chronological age saw the largest improvements. In C. elegans, the 3:1:1 mix increased lifespan 6–27% (greater than whole collagen). In old mice, it preserved grip strength and reduced white adipose tissue. Glycine, proline, and hydroxyproline form the backbone of collagen and play roles in protein synthesis, one-carbon metabolism, and likely signaling pathways that influence tissue maintenance and repair. These animal and human data together provide a compelling translational story.

We are seeking an #innovation-focused #postdoctoral researcher to develop and refine in-vitro protocols using #patient-derived #iPSCs for neuronal aging. novartis.com/careers/career…

I really liked the way Jan Gruber explained "biological aging" clocks at day 1 of @LongevityDublin. What should a useful clock be able to do? (1) Identify existing disease (2) Detect early, hidden and subclinical disease in an interpretable/explainable manner (3) Provide individual prognostication for future health risks/mortaility (4) Be useful for personalized intervention testing (5) Provide sufficient confidence to justify risk/reward

New brief on the Biology of Aging is out by the United Nations. Honored to be a Scientific Board Member. un.org/scientific-adv…

Targeting DNA damage in ageing: towards supercharging DNA repair, read now our latest article in @NaturePortfolio Nature Reviews in Drug Discovery. @ArBujarrabal @George_Garinis Paul Robbins Jan Vijg @CECAD_ @UKKoeln Free access to the article here: rdcu.be/eqK9r

New BSRA seminar incoming! On June 26 at 4pm UK time, we’re joined by Dr Della David (@BabrahamInst) for a deep dive into: “Strategies to Mitigate Age-Dependent Protein Aggregation” Free + open to anyone interested in ageing biology. bsra.org.uk/events/seminar…

Wonderful talk by @jangruber467 who was able to model a mystery from my former lab. If its all damage accumulation, how can the lifespan of C. elegans be doubled at the end of life? A physics derived model can explain it! youtu.be/pXFE_dcDIDc?si…

Exciting science on your end-of-year wish list?!? >> apply to our postdoc and PhD positions and start 2025 with a new job @UniBasel

#ARDD2024 Collin Ewald at ARDD2024: Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age youtu.be/2APxO5Tr8Z4

We are looking for a #physiologist to study how the age-related decline of organ homeostasis, and associated changes in #metabolism and #endocrine systems cross-talk contribute to #diseases of aging across the core therapeutic areas of @Novartis. Desirable #ECM #aging knowledge.

Congrats to @peter_meister’ s lab. Condensin I folds C.elegans folds genomes. nature.com/articles/s4158…

@LucaGiorgetti @vaquerizasjm And now nicely formatted here: rdcu.be/dOxQs

Roles for matrix/basement membrane proteins nidogen and laminin in sensing touch. C. elegans touch receptor neurons direct mechanosensory complex organization via repurposing conserved basal lamina proteins sciencedirect.com/science/articl…

📢New Open🔓Access Article Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age by Adrian Molière & Collin Y. Ewald (@CollinEwald) et al. rdcu.be/dME0d #endoflife #frailty #insulin #IGF1 #longevity #proteinhomeostasis #resilience

How To Choose a Good Scientific Problem (1/3)

Quality of supplements targeting aging: Testing the amount of nicotinamide mononucleotide and urolithin A as compared to the label claim | GeroScience (springer.com)

Registration closes this Friday, 21 June! 📣 We are looking forward to welcoming you in #Mainz next week. ➡️ imb.de/dgfa2024 #alternsforschung #ageingresearch

This study raises the possibility that the effect of #IIS and related pathways on resilience and frailty during aging in higher animals might possess some degree of reversibility. @GeroScienceAGE 🍬🔬👵 @AdrianMoliere @CollinEwald et al. link.springer.com/article/10.100…

Kudos to @AdrianMoliere, @ParkisLaelaps, and the team for pushing this over the finish line. I'm so happy this work got published! It looks like end-of-life doubling of lifespan upon daf-2 degradation potentially via restoring #protein #homeostasis.