Comprehensive Psychiatry

Will temporal interference step into the spotlight in 2026 for Parkinson’s and beyond? Temporal interference refers to using two high-frequency electrical currents to create a lower-frequency stimulation that can non-invasively reach deeper brain regions. Demchenko and colleagues describe in a new paper in Brain Stimulation that temporal interference stimulation is emerging as a safe and promising way to non-invasively reach deep brain circuits in disorders like Parkinson’s and beyond. Key Points: - Temporal interference stimulation uses high frequency electrical currents to create a deeper and more focused stimulation w/ minimal scalp sensation. - Early Phase 1 trials across 820 participants show safety, good tolerability and measurable effects on some motor circuits and on memory systems. - In preliminary Parkinson’s studies, stimulation targeting basal ganglia circuits led to short-term improvements in tremor and bradykinesia. My take: We will need novel tools and technologies to move the field of brain stimulation for Parkinson's and other neuropsychiatric diseases to a new level. Temporal interference is of great interest as it is non-invasive and can reach deep into the brain. Here are 5 points that resonated w/ me: 1- Temporal interference aims deep while remaining non-invasive. Could it one day replace or complement DBS for folks w/ Parkinson’s? 2- Studies show reduced tremor and bradykinesia shortly after stimulation, however more trials are needed to understand its durability. 3- The technology engages key brain circuits including motor and memory networks, frequently aligning stimulation timing w/ real-time tasks to improve results. 4- Side effects reported so far seem to be mild such as tingling or itching and the safety profile looks strong in the early studies. 5- Larger multi-session trials are underway to determine if this technology can meaningfully impact symptoms across movement and other psychiatric conditions. Nir Grossman and Ed Boyden introduced the technique several years past in the journal Cell. sciencedirect.com/science/articl… @movedisorder @GreenJournal @SfNtweets @brainstimj @DBSThinkTank @FixelInstitute @ParkinsonDotOrg

"Exploring Biological Risk Factors in Treatment-Resistant #Depression" 🖊️by Francisco Javier Lievanos-Ruiz and Bertha Fenton-Navarro 🔗mdpi.com/2673-5318/6/4/… #majordepressivedisorder #depression #mdpi

Men 4X more likely to commit suicide/Women 3X more likely to attempt Why disparity: 1)Men use guns 2)Women seek help 3)Risk factors work better in women Large & important study with 2 clear clinical implications: 1)Do especially careful suicide evals in men 2)Reduce gun access

For women with endometriosis, side-effects from current hormone-based treatment options are unacceptable. A new study examines dichloroacetate, a possible non-hormonal alternative, for endometriosis-associated pain: hubs.li/Q03RNMRC0

Grey hairs and Vitamin B12 Vitamin B-12 deficiency is one of the most common causes of prematurely graying hair.

Shyness May Originate in the Cerebellum A new study reveals that individuals with higher levels of shyness show decreased neural synchrony in the cerebellar Crus I region. Using resting-state fMRI and ReHo analysis, researchers identified a brain-based marker of shyness that operates even when the brain is at rest. The Behavioral Inhibition System (BIS), which governs avoidance behavior, was shown to partially mediate this neural relationship. These findings highlight the cerebellum as a key structure in personality traits, offering new pathways for understanding social anxiety.

New findings published in Psychiatry Research suggest that schizophrenia is linked to changes in neuron size within the brain’s anterior cingulate cortex. These cellular changes appear to relate to hallucination severity. dlvr.it/TP9G7Q

The risk of recurrent atrial fibrillation was significantly lower in the group allocated to coffee consumption (47%) compared with the abstinence group (64%).

Hidden Markov Models Really enjoyed this paper on dynamics underlying resting state and other conditions. The idea of a baseline state from which excursions lead to more integrated states is really interesting. elifesciences.org/articles/85487…

Multiple sclerosis is generally speaking less heritable than many other neurological diseases. pmc.ncbi.nlm.nih.gov/articles/PMC12…

#IAGen y #EvaluaciónTecnologíaSanitaria: qué aporta y qué no Artículo q revisa cómo la IA generativa puede acelerar la ETS sin reemplazar la supervisión experta 3 ámbitos clave: revisiones sistemáticas, evidencia del mundo real y modelización económica 10.1016/j.jval.2024.10.3846

No clear evidence to support any link between maternal acetaminophen (Tylenol) intake and autism or ADHD in offspring, a new umbrella systematic review @bmj_latest

We now know the cascade of sleep deprivation → brain fog A major role of sleep is to clear brain junk via CSF pulses (think - flushing a toilet) When we're sleep deprived, those pulses happen while we're awake. Each pulse is driven by norepinephrine, and drops attention.

New study @BMJMentalHealth: Suicide risk indicators vary by sex and age. In Sweden (2009–2021), men & older adults showed fewer and weaker warning signs before suicide, making prevention harder. But when present, risk signs meant higher absolute risk for men. Read more 👇🏼 mentalhealth.bmj.com/content/28/1/e… #SuicidePrevention #MentalHealth #PublicHealth #Epidemiology #SuicideResearch #MensHealth #Aging #BMJMentalHealth

RCT: In patients with #schizophrenia, #prediabetes, and #obesity, once-weekly #semaglutide injections, up to 1.0 mg/week, were safe and effective. ja.ma/3XdRoZw

Your heart runs on a clock, and when that clock falls out of sync, your metabolism and cardiovascular health begin to break down. What you’re seeing This figure from the American Heart Association illustrates how circadian rhythms—the body’s internal 24-hour timing system—coordinate functions across the brain, heart, liver, and other organs. When sleep, light exposure, eating, and activity patterns fall out of rhythm, the body’s finely tuned systems lose synchronization. 🟡 The brain’s “master clock” in the hypothalamus aligns daily cycles of metabolism, blood pressure, and hormone release 🟡 Disruption from shift work, late-night light, irregular meals, or poor sleep desynchronizes these rhythms 🟡 This misalignment leads to insulin resistance, chronic inflammation, and higher risk for obesity, hypertension, and heart disease Reestablishing alignment involves timed exposure to light, consistent sleep and meal schedules, and regular exercise. Morning light, early-day activity, and minimizing light at night help restore the body’s natural timing. 💡 The bigger picture Circadian health is as vital as diet and exercise for heart protection. Supporting the body’s biological clock keeps metabolism, vascular function, and hormone balance in sync—reducing the long-term risk of cardiovascular disease and metabolic disorders. doi:10.1161/CIR.0000000000001388

New BMJ Research: Existing evidence does not clearly link paracetamol (acetaminophen) use during pregnancy with autism or ADHD in children, finds an in-depth evidence review bmj.com/content/391/bm…

They shall grow not old, as we that are left grow old: Age shall not weary them, nor the years condemn. At the going down of the sun and in the morning We will remember them. #RemembranceSunday #LestWeForget

🌏 Despite substantial progress in recent years, asthma still poses an unacceptable health burden globally. A joint @TheLancet & @LancetRespirMed Series provides new insights into the genetics, prevention, and risk factors of the disease: hubs.li/Q03S7_Qp0

What helps some children thrive cognitively despite growing up in poverty? In this #MindtheKids episode, @Divyanganar joins @DrJaneGilmour & @umartoseeb to discuss resilience in disadvantaged youth. 🎧 Listen now: bit.ly/3JNughu