Francisco Cárdenas, MD

Great start to alpine colorectal meeting! #aplinecolorectalmeeting #ACM2026

AGA Clinical Practice Update on Inpatient Management of Adults With #IBD : Expert Review gastrojournal.org/article/S0016-… @AmerGastroAssn @AGA_Gastro Over the next couple of days I am going to summarize the recommendations of this AGA CPU by @ShirleyCoMekMD @JHashashMD @IBDMD and me 🧵

Efficacy and safety of oral 5‐FU‐based adjuvant chemotherapy for geriatric patients with colorectal cancer: Integrated analysis of seven clinical trials conducted at the Japanese Foundation for onlinelibrary.wiley.com/doi/full/10.11… open access @ColorectalDis

How to talk to your IBD pt about diet and fiber per @nehagastrord @ucsfibd Updates.

Preoperative HIIT was found to be both feasible and safe for preoperative patients and led to meaningful physiological and functional benefit. journals.lww.com/annalsofsurger…

Improved 5‐year survival with robot‐assisted resection for locally advanced rectal cancer compared to laparoscopic and open surgery: A real‐world cohort study onlinelibrary.wiley.com/doi/full/10.11… @ColorectalDis open access

#DCRJournal Visual Abstract | Tumor Deposits in Colon Cancer: bit.ly/3JwIClY

Traditional 28-day wait time targets for colorectal cancer surgery were not linked to survival, but surgery within 45 days was associated with improved overall survival . journals.lww.com/annalsofsurger…

👇🏽This is an excellent read 📕 📖 🔖 if you get a chance @JCO_ASCO #TumorBoardTuesday

Día 3 — seguimos avanzando en el Congreso. Hoy continúan los cursos de PG2 y las sesiones académicas que marcan la diferencia en la cirugía. Gracias por acompañarnos en este espacio de actualización, aprendizaje y compañerismo. #XLIXCongresoCirugía #AMCG

La formación médica continua es pilar fundamental en el desarrollo quirúrgico. En el XLIX Congreso Internacional de Cirugía General, se promueve la actualización científica, el análisis crítico y la colaboración entre expertos nacionales e internacionales, reafirmando el compromiso de la AMCG con la excelencia académica y la mejora constante de la práctica médica. #AMCG #CongresoAMCG #EducaciónMédica #León2025 #CirugíaGeneral

Reviewing the utility of ctDNA in rectal cancer with @pashtoonkasi published today @OncJournal academic.oup.com/oncolo/article…

Cada edición del Congreso Internacional de Cirugía General representa una historia de esfuerzo, aprendizaje y crecimiento profesional. El XLIX Congreso reafirma el compromiso de la AMCG con la excelencia quirúrgica y la formación continua. 🙌 Gracias a todos los que hacen posible este espacio de encuentro, ciencia e innovación. #AMCG #CongresoAMCG #CirujanosDeMéxico #León2025 #OrgulloQuirúrgico

NICHE-2 absolutely delivers. Game over for chemo in dMMR colon cancer 💥🧬 In locally advanced dMMR colon cancer, FOxTROT already showed us chemo doesn’t work, and now NICHE-2 makes it undeniable. 💊 Neoadjuvant nivolumab + ipilimumab → • 99% pathologic response • 67% pathologic CR • Zero recurrences to date at 3 years 🪦 This is the final coffin nail for perioperative chemotherapy in this setting. ATOMIC is already on life support despite being published less than a year ago. The real question now: with Cercek’s rectal data, can we safely omit surgery next? At minimum, this should be the new standard. At maximum, it’s the start of a paradigm shift. @OncoAlert @TheGutOncLab #ESMO25

@myESMO 2025 Recap: Top GI Cancer Trials and Key Results Explore more insights and data from #ESMO25: t.ly/yDvnj #LARVOL #CancerResearch #CancerData #Oncology #OncologyInsights #ClinicalTrials #MedicalOncology #ESMO2025 #GICancer | @Erman_Akkus | @ArndtVogel | @GIMedOnc | @UGrewalMD | @graokane | @GillSharlene

Proud to present combined NICHE-2 & FOXTROT analysis in dMMR locally advanced CC -Neoadjuvant IO superior to chemo -20% relapses with chemo in "good prognosis" group; 30% if T4 -Minimal path response to chemo - Clinical staging identified high risk group

🔥 Liver Arsenal for Colorectal Cancer - who rules 2025? 🎯 Resection still reigns, but new contenders are rising fast. Here’s how every liver-directed therapy stacks up 👇 🩺 1️⃣ Resection & Ablation •Gold standard if R0 & FLR adequate •MWA > RFA 🔥 •COLLISION Trial 2025: MWA non-inferior to resection (5-yr OS 51% vs 58%) •Combo resection + ablation → ↓ hepatic failure, same DFS/OS 💉 2️⃣ Hepatic Artery Infusion (HAI) •Targets arterial tumor flow → high local FUDR dose •10-yr OS 41% vs 27% with adjuvant HAI •Conversion to resection ≈ 30–50 % •🔬 PUMP Trial ongoing (NCT05863195) ☢️ 3️⃣ Trans-Arterial Radioembolization (TARE) •Y-90 beads for chemo-refractory CRLM •↑ PFS 9.1 vs 7.2 mo, no OS gain (~14 mo) •Use selectively in expert centers 🔆 4️⃣ SBRT / MRI-LINAC •Option for inoperable oligomets < 4 cm •5-yr local control ≈ 78 %, OS ≈ 18 % 🫀 5️⃣ Transplant (TRANSMET Trial 2024) •5-yr OS 56.6 % vs 12.6 % with chemo alone •Highly selected: < 65 y, no BRAF, CEA < 80 µg/L 🧬 6️⃣ Histotripsy -Next-Gen Ultrasound Therapy •Non-invasive tumor lysis tech •HOPE4LIVER: 96 % technical success ✅ (FDA-approved 2025) •Await PFS/OS data in 2026 💡 Takeaway: No single “winner” - each liver-directed therapy plays a role. 👉 Resection offers cure, ablation extends resectability, HAI deepens control, and TARE/SBRT aid palliation or bridge to surgery. Future belongs to integration, not competition. 👉 Multidisciplinary, patient-tailored sequencing is key. 🔖 Bookmark for tumor-board pearls 📖 Folkerts AD et al. Cancer 2025 🔗 acsjournals.onlinelibrary.wiley.com/doi/10.1002/cn… #OncoTwitter #MedTwitter #ColorectalCancer #LiverMets @OncoAlert @myESMO @esmo_open @ASCO

Factors influencing locoregional recurrence rates in locally advanced rectal cancer after total neoadjuvant treatment versus chemoradiotherapy in the RAPIDO trial ➡️ doi.org/10.1093/bjs/zn… The difference in LRR between TNT and CRT mainly occurred in patients treated with sphincter-preserving surgery Baseline information on the original tumour bed should be considered when determining the surgical approach after total neoadjuvant treatment Work by Ilaria Prata, Max D Tanaka, Bengt Glimelius, Iris D Nagtegaal, Regina G H Beets-Tan, Lennart K Blomqvist, Alice M Couwenberg, Boudewijn van Etten, Geke A P Hospers, Elma Meershoek-Klein Kranenbarg, Koen C M J Peeters, Hein Putter, Annet G H Roodvoets, Cornelis J H van de Velde, Per J Nilsson, Corrie A M Marijnen #SoMe4Surgery #MedTwitter #SurgEd #Surgery @RCPSGTrainees @aecirujanos @SEIQuirurgica @iss_sic #MedicalTechniques @BJSAcademy @young_bjs @BJSOpen @des_winter @evanscolorectal @robhinchliffe1 @bplwijn @MalinASund @nfmkok @TejedorPat @paulo_sutt @PVaughanShaw @JJEarnshaw @juliomayol @ksoreide #colorectalsurgery #StepUp4CRC @FightCRC @ACPGBI #ERAS @dice_europe #Crohn #proctology @Dukes_Club @ACPGBI_EduTrain @AECP_FAECP @PelvExGroup @escp_tweets @YouESCP #TeachMeColoproctology #Some4COLoprocto

Don’t miss this webinar next Sunday @ISUCRS1 @PortalSBCP @ASCRS