Florian Sicklinger retweetledi
Florian Sicklinger
38 posts
Florian Sicklinger
@FloSicklinger
Physician-Scientist, investigating innate immunity in cardiovascular disease @uniklinik_hd
Heidelberg, Germany Katılım Ağustos 2020
334 Takip Edilen183 Takipçiler
Using the first mouse model of tricuspid valve regurgitation, we identify a cardio-intestinal innate immune circuit in which chronic venous congestion reprograms monocytes into IL-6-producing drivers of heart failure.
doi.org/10.64898/2026.…
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Florian Sicklinger retweetledi
Do we study the right biology after myocardial infarction (MI)?
• Surgery in standard mouse model masks MI-specific immune responses
• Minimally invasive model better reflects patient immune responses & reveals immature neutrophils worsen heart function
tinyurl.com/MImodels
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Florian Sicklinger retweetledi
#SpatialOmics #MyocardialInfarction
#MolecularCartography 100-gene + #SeqIF 12-marker + #DeepVisualProteomics
4/24/49/96 h postMI🐭
Endocardial vWF mediates Mɸ infiltr
Anti-vWF i.v. reduces Mɸ at endocardial, but not epicardial, core or border, zone, but causes infarct wall thinning + worsened cardiac adaptation by 2 wk
Cellpose 2 human-in-a-loop for CardioMyocyte segmentation
Ankrd1 pixel cluster to demarcate stressed/dying CM
Custom analysis pipeline
github.com/SchapiroLabor/…
@flowuenne @FloSicklinger @DenisSchapiro @NatureCVR 2025
nature.com/articles/s4416…
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Florian Sicklinger retweetledi
von Willebrand factor is upregulated after myocardial infarction and facilitates recruitment of Ccr2+ monocytes that worsen cardiac function
@flowuenne @FloSicklinger @DenisSchapiro
nature.com/articles/s4416… @NatureCVR @HeidelbergU @uniklinik_hd 🇩🇪
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Florian Sicklinger retweetledi
Please join us for our 2nd Immuno-Cardiology Symposium in beautiful Bar Harbor, Maine, Sept. 18-19! @jacksonlab @MDIBL explore how dysregulated immune system function contributes to inflammation and fibrosis in disease and related disorders in the kidney, lung and liver
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Florian Sicklinger retweetledi
Sicklinger & colleagues developed a new #ultrasound-guided method to induce #HeartAttacks in mice, allowing precise control & real-time monitoring without the need for invasive surgery. Learn more at ahajrnls.org/42R7ZGs
@volkersmirko @junedh_amrute @rkramann
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Florian Sicklinger retweetledi
Check out the latest issue of @CircRes with our Echo-Guided IR Method on the cover ♥️ 🥢
Circulation Research@CircRes
@CircRes May 9th Issue is Out! ahajrnls.org/3wPOBJJ Cover: Representative IF staining of endothelial cells (magenta), inflammation (yellow), & WGA (green) in a 4-chamber view of a heart 7 days after Echocardiography-Guided Induction of I/R;nuclei-blue.
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@AsAshraf123321 @CircRes @LeuschnerLab @LavineLab @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF Thank you !
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@FloSicklinger @CircRes @LeuschnerLab @LavineLab @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF Congratulations 🎊
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In @Circres we describe a novel Echocardiography-Guided Method for Induction of Myocardial Ischemia/Reperfusion.
Check out the full study here: doi.org/10.1161/CIRCRE…
Great collaborative effort with @leuschnerlab, @lavinelab, @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF
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@SusannaTECooper @CircRes @LeuschnerLab @LavineLab @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF Thank you Susanna !
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@FloSicklinger @CircRes @LeuschnerLab @LavineLab @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF Congratulations Florian!
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@KuppeChristoph @CircRes @LeuschnerLab @LavineLab @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF Thanks Christoph !
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@FloSicklinger @CircRes @LeuschnerLab @LavineLab @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF Congrats Florian! 🎊
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Florian Sicklinger retweetledi
In @Nature we use single cell multiomics, fibroblast fate tracing, and in vivo models to characterize immune fibroblast crosstalk in heart failure with @LavineLab @washumedicine, @Amgen , and @ImmunoFibHF nature.com/articles/s4158…
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Florian Sicklinger retweetledi
Check out our paper just published in Circulation
➡️ Translation controls inflammation after myocardial infarction
doi.org/10.1161/CIRCUL…
This work was a huge collaborative effort over many years.
@dzhk_germany @DGK_org @VolkersMirko
Key findings + paper summary below 🧵⬇️⬇️⬇️
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Florian Sicklinger retweetledi
Very happy that our manuscript is now online @CircAHA. Transient inhibition of translation protects against #reperfusion injury. Kudos to first author @ChrlsHofmann and to all Co-authors for a great team effort. @CRC1550 @dzhk_germany @uniklinik_hd ahajournals.org/doi/abs/10.116…
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Thanks to @BronwynBerkeley for highlighting our method in @NatRevCardiol
Bronwyn@BronwynBerkeley
Read my Tools of the Trade article, published in @NatRevCardiol, highlighting my experience with and the method of ultrasound guided induction of myocardial infarction: rdcu.be/dLgU3 Thanks to @FloSicklinger & F. Leuschner for developing such an innovative method.
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Florian Sicklinger retweetledi
A shortcut to the infarcted heart
Excited to share our collaborative effort with @DenisSchapiro lab led by @FloSicklinger and @FloWuenne. Using spatial omics technologies, we found a new way how monocytes sneak into the infarcted heart.
biorxiv.org/content/10.110…
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Florian Sicklinger retweetledi
I am very excited to share our lab's first preprint @uniklinik_hd together with the @LeuschnerLab. This study was led by @FloWuenne and @FloSicklinger. biorxiv.org/cgi/content/sh…
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Florian Sicklinger retweetledi
🩵💙🩵💙great symposium - great people - great location!! 🩵💙🩵💙#ImmunoCardiology @jacksonlab #leducq #immunofibHF
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