Florian Sicklinger

36 posts

Florian Sicklinger

@FloSicklinger

Physician-Scientist, investigating innate immunity in cardiovascular disease @uniklinik_hd

Heidelberg, Germany Katılım Ağustos 2020

337 Takip Edilen185 Takipçiler

Florian Sicklinger retweetledi

ᒍOᕼᗩᑎ ᗪᑌᑕᕼEᑎE@DucheneJohan·9 Mar

Do we study the right biology after myocardial infarction (MI)? • Surgery in standard mouse model masks MI-specific immune responses • Minimally invasive model better reflects patient immune responses & reveals immature neutrophils worsen heart function tinyurl.com/MImodels

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Florian Sicklinger retweetledi

Hao Yin@HaoYin20·14 Eki

#SpatialOmics #MyocardialInfarction #MolecularCartography 100-gene + #SeqIF 12-marker + #DeepVisualProteomics 4/24/49/96 h postMI🐭 Endocardial vWF mediates Mɸ infiltr Anti-vWF i.v. reduces Mɸ at endocardial, but not epicardial, core or border, zone, but causes infarct wall thinning + worsened cardiac adaptation by 2 wk Cellpose 2 human-in-a-loop for CardioMyocyte segmentation Ankrd1 pixel cluster to demarcate stressed/dying CM Custom analysis pipeline github.com/SchapiroLabor/… @flowuenne @FloSicklinger @DenisSchapiro @NatureCVR 2025 nature.com/articles/s4416…

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Florian Sicklinger retweetledi

Waggoner Lab@LabWaggoner·3 Eki

von Willebrand factor is upregulated after myocardial infarction and facilitates recruitment of Ccr2+ monocytes that worsen cardiac function @flowuenne @FloSicklinger @DenisSchapiro nature.com/articles/s4416… @NatureCVR @HeidelbergU @uniklinik_hd 🇩🇪

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Florian Sicklinger retweetledi

Rafael Kramann, MD PhD@rkramann·31 Tem

Please join us for our 2nd Immuno-Cardiology Symposium in beautiful Bar Harbor, Maine, Sept. 18-19! @jacksonlab @MDIBL explore how dysregulated immune system function contributes to inflammation and fibrosis in disease and related disorders in the kidney, lung and liver

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Florian Sicklinger retweetledi

Circulation Research@CircRes·10 May

Sicklinger & colleagues developed a new #ultrasound-guided method to induce #HeartAttacks in mice, allowing precise control & real-time monitoring without the need for invasive surgery. Learn more at ahajrnls.org/42R7ZGs @volkersmirko @junedh_amrute @rkramann

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Florian Sicklinger retweetledi

Leuschner Lab@LeuschnerLab·8 May

Check out the latest issue of @CircRes with our Echo-Guided IR Method on the cover ♥️ 🥢

Circulation Research@CircRes

@CircRes May 9th Issue is Out! ahajrnls.org/3wPOBJJ Cover: Representative IF staining of endothelial cells (magenta), inflammation (yellow), & WGA (green) in a 4-chamber view of a heart 7 days after Echocardiography-Guided Induction of I/R;nuclei-blue.

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Florian Sicklinger@FloSicklinger·15 Nis

@AsAshraf123321 @CircRes @LeuschnerLab @LavineLab @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF Thank you !

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Ashraf Saad, bridging Glycobiology and Oncology!@AsAshraf123321·15 Nis

@FloSicklinger @CircRes @LeuschnerLab @LavineLab @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF Congratulations 🎊

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Florian Sicklinger@FloSicklinger·15 Nis

In @Circres we describe a novel Echocardiography-Guided Method for Induction of Myocardial Ischemia/Reperfusion. Check out the full study here: doi.org/10.1161/CIRCRE… Great collaborative effort with @leuschnerlab, @lavinelab, @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF

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Florian Sicklinger@FloSicklinger·15 Nis

@SusannaTECooper @CircRes @LeuschnerLab @LavineLab @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF Thank you Susanna !

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Susanna Cooper@SusannaTECooper·15 Nis

@FloSicklinger @CircRes @LeuschnerLab @LavineLab @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF Congratulations Florian!

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Florian Sicklinger@FloSicklinger·15 Nis

@KuppeChristoph @CircRes @LeuschnerLab @LavineLab @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF Thanks Christoph !

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Christoph Kuppe@KuppeChristoph·15 Nis

@FloSicklinger @CircRes @LeuschnerLab @LavineLab @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF Congrats Florian! 🎊

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Florian Sicklinger@FloSicklinger·15 Nis

@T_Thiemann @junedh_amrute @LauraWienecke @dav_schumacher @TimChristianKu1 @CRC1550

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Florian Sicklinger retweetledi

Junedh M. Amrute@junedh_amrute·23 Eki

In ⁦@Nature⁩ we use single cell multiomics, fibroblast fate tracing, and in vivo models to characterize immune fibroblast crosstalk in heart failure with ⁦@LavineLab⁩ ⁦@washumedicine⁩, ⁦⁦@Amgen⁩ , and ⁦@ImmunoFibHF⁩ nature.com/articles/s4158…

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Florian Sicklinger retweetledi

Christoph Sandmann@chris_sandmann·13 Eyl

Check out our paper just published in Circulation ➡️ Translation controls inflammation after myocardial infarction doi.org/10.1161/CIRCUL… This work was a huge collaborative effort over many years. @dzhk_germany @DGK_org @VolkersMirko Key findings + paper summary below 🧵⬇️⬇️⬇️

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Florian Sicklinger retweetledi

Mirko Volkers@VolkersMirko·3 Eyl

Very happy that our manuscript is now online @CircAHA. Transient inhibition of translation protects against #reperfusion injury. Kudos to first author @ChrlsHofmann and to all Co-authors for a great team effort. @CRC1550 @dzhk_germany @uniklinik_hd ahajournals.org/doi/abs/10.116…

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Florian Sicklinger@FloSicklinger·20 Haz

Thanks to @BronwynBerkeley for highlighting our method in @NatRevCardiol

Bronwyn@BronwynBerkeley

Read my Tools of the Trade article, published in @NatRevCardiol, highlighting my experience with and the method of ultrasound guided induction of myocardial infarction: rdcu.be/dLgU3 Thanks to @FloSicklinger & F. Leuschner for developing such an innovative method.

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Florian Sicklinger retweetledi

Leuschner Lab@LeuschnerLab·22 May

A shortcut to the infarcted heart Excited to share our collaborative effort with @DenisSchapiro lab led by @FloSicklinger and @FloWuenne. Using spatial omics technologies, we found a new way how monocytes sneak into the infarcted heart. biorxiv.org/content/10.110…

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Florian Sicklinger retweetledi

Denis@DenisSchapiro·22 May

I am very excited to share our lab's first preprint @uniklinik_hd together with the @LeuschnerLab. This study was led by @FloWuenne and @FloSicklinger. biorxiv.org/cgi/content/sh…

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Florian Sicklinger retweetledi

ImmunoFibHF@ImmunoFibHF·22 Eyl

🩵💙🩵💙great symposium - great people - great location!! 🩵💙🩵💙#ImmunoCardiology @jacksonlab #leducq #immunofibHF

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Florian Sicklinger retweetledi

Susanne Sattler@notimmuneatall·21 Eyl

Florian Leuschner Kicking off the first US immunocardiology conference at @jacksonlab. @ImmunoFibHF Very excited about what’s in store the next three days! #CardioTwitter #cardioimmunology

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Florian Sicklinger retweetledi

ImmunoFibHF@ImmunoFibHF·29 Haz

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Keşfet

@flowuenne @DenisSchapiro @NatureCVR @HeidelbergU @uniklinik_hd @jacksonlab @MDIBL @VolkersMirko