Isabel Burnett | Renegade Research

My son published the first book of a series he is writing. IF you can, please support him for yourself (if you like the genre) or to gift to someone. a.co/d/6gIKvRv

I am very excited about this roundtable. I first heard Dr Spiritos on the @bendy_bodies podcast and called @NovaSupport super excited and she reached out and made it happen. Please invite your clinicians as this provider is a great example of what can be done!

📊 Poll Glucocorticoids (Steroids) 💊 Your #MECFS #LongCovid Experience with Prednison, Dexamethasone, Hydrocortisone Methylprednison, etc. 1) What is your Overall experience with Glucocorticoids (Steroids) ? (*More Questions below AND please add yr Comments👇🏻) (1/7)

@candlelovers12 @Naomi_D_Harvey @EricTopol @NatureMedicine Vets 🫶🏽

@IsabelRamirezRD @Naomi_D_Harvey @EricTopol @NatureMedicine My guinea pigs get probiotics rx when they need anti biotics.

A single dose of antibiotics can have lasting effects on your gut microbiome, with changes that last well beyond 4 years. Three types of antibiotics stood out for their long term disruptive impact (3 at left, Figure) @NatureMedicine nature.com/articles/s4159…

Dominican team draws first blood @WBCBaseball 🎊🥎🎊

This great roundtable is now posted to our YT channel

@ValerieJay16 @EricTopol @NatureMedicine It should be done during, not just after

@EricTopol @NatureMedicine How can one improve their microbiome after being on antibiotics?

@Naomi_D_Harvey @candlelovers12 @EricTopol @NatureMedicine I don’t understand how knowing what we know about the microbiome, they still rx abx w/o a plan to restore & letting them get wiped out during the course of trx

@candlelovers12 @EricTopol @NatureMedicine Woah 😧 I just saw that on the side effects list. My husbands been prescribed it and he’s only in the third dose but he’s feeling absolutely awful with nausea.

@MaryGR65 @Naomi_D_Harvey Yes, I have taken it for about 2 years some of that time intermittently. Tagging @joshual_tm to link to the info on BF

@IsabelRamirezRD @Naomi_D_Harvey Did you take it for long Isabel, did it help at all. Im just clutching at straws now I think, either that or admit after 6yrs that this is the best it going to get.

Hi fellow #PWLC, #PWME. Whats the word on Methylene Blue these days? Anyone taking it, liking it, not liking it 🤷‍♀️

@Naomi_D_Harvey @MaryGR65 Even less than 1mg for mito. The born free website has lots of info on it iirc

@MaryGR65 I don’t, it’s a very long list so I’d just Google it x

📊Patient survey data PREGABALIN 💊 (incl Gabapentin) #MECFS #LongCovid - Reviewed 69 Anecdotes + 4 online polls N = 566 patients experiences • 50% clear/partial benefit ✔️ • 26% no benefit ♾️ • 5% mixed experience ➖/➕ • 24% side effects / stopped / withdrawal sx ✖️ 1/n

@internetuserf12 Is it available as a PDF or ebook?

Thanks to another donation, I'm able to give away more copies of my book but only in the states. The first few folks to fill out this online form will receive a nice, signed😉 paperback copy: intakeq.com/new/zs4hc3 Thank you all for the support. ❤️‍🔥

@Michaeltikus @internetuserf12 @tessfalor 🙏🏾

@internetuserf12 @IsabelRamirezRD @tessfalor

@KyleMcnease @AlmostMedia @RenegadeRes @Canal1point5

@AlmostMedia that is awesome! i will read the blog. @RenegadeRes do you know if anyone has analyzed & published the data on all the nicotine test results?

Help this guy. I was once him. This mission is vital

@AlisonNolan9 @kirstler31 Yes it will. Is there something else that can get you by to stop it for a week for the test?

@kirstler31 @IsabelRamirezRD I've currently got an appointment in April - it took me a hour to even get in the phone queue starting at 8:30 this morning. I'm a bit worried that the test is going to come up negative because I've been on 40mg famotodine for months and they'll refuse to treat without an

Has anyone with severe ME dealt with a H. pylori infection? I've been in denial for months but it's getting really difficult to eat at times now. Looking at the NHS treatment guidelines I'd probably need to take: Lansoprazole 30mg twice a day Plus

@kirstler31 @AlisonNolan9 There is no blanket statement that can be made on safety of one abx let alone a combination. These decisions are best made in combination with the prescribing clinician and someone who can evaluate microbiome and other factors in the personal context, especially in severe.

@AlisonNolan9 @IsabelRamirezRD

@KatBoniface @RenzPolster @Naomi_D_Harvey @tamararivc @doc4care x.com/IsabelRamirezR… @dokter_Arf : Adding to this

Please join us for an X/Twitter Space Discussion for Long COVID Awareness Week on March 17 at 4 pm ET US! (in honor of Long Covid Awareness Day on March 17) Moderators: @IsabelRamirezRD and @emily_rj We will be hosting a discussion to talk about Long COVID community thoughts, feelings, concerns, needs, research and care. All are welcome! X space link in next post 🧵

@pcasa1_ @austinxwalker @julie_bush @RenegadeRes @tessfalor Thanks Patricia. Nice to meet you Austin. Sent a DM.

@austinxwalker @julie_bush @RenegadeRes @tessfalor @IsabelRamirezRD renegade-research.org

a few years ago i got covid and never recovered. i went from exercising every day to completely bedbound. lost 40lbs. in and out of hospitals for over 2 years. saw 20+ doctors. bloodwork came back normal. "you're probably just stressed from being a founder."

Its such a disservice that the effects of meds/vaccines have gotten to be a political topic, often within a narrow therapeutic aspect. The truth with all of them is far more nuanced than the headlines and political posturing on them. I always look at the history/uses, research and clinical data rather than acceptance/opposition to an emerging use (as it happened with covid/LC) and how it does and does not make sense based on multiple mechanisms of action not just the conditions that such med has approval for. Science is never settled, but also one cannot make definite assertions based on limited sample sets or baed on administration of a compound under a particular set of circumstances. The way that things get studied influences the outcome

@rhirhiarhii @imMEurMEweallME @renesugar @arta_semita @chydorina @tessfalor @IsabelRamirezRD Anyone interested in this?

So I have to come out of the closet as an ivermectin fan :) as a person who is the opposite of a MAGA. Who is interested in discussing Ivermectin's mechanisms with me? Particularly ones relevant for neuro-excitotoxicity and neuro-degeneration. Especially possibly through ***α7 nicotinic acetylcholine receptor** effects.. I got really curious and started experimenting with it (human/pharmacy grade); definitely noticeable and promising autonomic/cognitive/physical results. *cautions/major side effect below. Yes, I know it’s *direct* anti-viral/covid effects, at usual doses, have been debunked. I wasn’t convinced the effects are solely due to anti-parasitic mechanisms, especially since they would reach a ceiling effect when most of the parasites are expunged by the 2nd dose as it’s designed, or even by Nth dose for argument’s sake. So then I came upon this study that Ivermectin has effects on ***α7 nicotinic acetylcholine receptor,*** also affected by… 🥁🥁nicotine.. (Ivermectin is not a direct agonist of those receptors, but a “positive allosteric modulator”) I remember spending hours using AI and my own search for other agents that can remotely have agonist-like effect on a7nAChR when I saw my dramatic, albeit temporary, response to nicotine, and Ivermectin did NOT come up.. ***** I think it invites a question of why the same population that tends to greatly benefit from nicotine patches might also be benefiting from Ivermectin? As some research suggests- what is going on with those damn α7 nicotinic acetylcholine receptors in a subset of us & thus the effects of nicotine & ivermectin on them? I have not before seen this link made in mainstream Long Covid land, including in the original FLCC, etc but saw a few Dr’s in the “other” corner of twitter making it once I dove in. There is also this new mouse study where ivermectin had neuroprotective effects on Alzheimer’s-like stricken mice, and another where it had protective effects against MSG induced neuro-toxicity. Curious if anyone else is interested and wants to share/ think through those potentially/hopefully beneficial nicotinic receptor or acetylcholinesterase inhibitor related effects? I'm especially interested in if Ivermectin would be a safer, cheaper, more accessible anti-neurotoxicity medication in our population. At the same, I know it's not remotely as safe as MAGA promises, and it DOES seem to cross blood brain barrier and fry my vision! probably through GABA-ergic effects Ivermectin Binding to α7nAChR paper pmc.ncbi.nlm.nih.gov/articles/PMC10… Ivermectin & mouse model Alzheimer’s pubmed.ncbi.nlm.nih.gov/40879672/ Ivermectin & mouse model reduced neurotoxicity eprints.lmu.edu.ng/2342/ *Admittedly my addled brain cannot engage any of this in detail, let alone, rigor.

@DrMichaelScoma @Wired63 We did this webinar with Drs kauffman and Dempsey on what they are seeing in their practice too youtu.be/lC3caaV7WP0?si…

@Wired63 I usually start with 0.25 mg or 0.5 mg weekly.

Tirzepatide in ME/CFS, Long COVID, and MCAS In a spectrum where many interventions prove inconsistent, microdosed tirzepatide has demonstrated a reproducible clinical signal in my practice. The relative consistency observed justifies examining plausible biologic mechanisms. 🧵