Timothy Kerwin, MD

Disruptive Analysis of Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer: Clinical and Therapeutic Distinctions Between Low- and Mid-Rectal Cancers. Read the full article. ascopubs.org/doi/abs/10.120… #gicsm

Adaptive radiotherapy involves modifying treatment plans to account for changes in anatomical geometry that are not adequately mitigated with changes in alignment. Online adaptive radiotherapy capitalizes on advances in image guidance, real-time tumor tracking, and the enhanced speed of multiple steps in radiotherapy planning and delivery workflows (seen in image). Learn more in the Review Article “Effects of Radiotherapy in Normal Tissue” by @DeborahCitrin, MD, and Robert D. Timmerman, MD (@BobTimmermanMD), from the National Cancer Institute and @UTSWMedCenter: nejm.org/doi/full/10.10…

A new review summarizes advances in radiotherapy that reduce injury to normal tissue, including improvements in the precision of imaging and delivery, and outlines strategies to prevent and manage treatment-related side effects. Read the Review Article “Effects of Radiotherapy in Normal Tissue” by @DeborahCitrin, MD, and Robert D. Timmerman, MD (@BobTimmermanMD), from the National Cancer Institute and @UTSWMedCenter: nejm.org/doi/full/10.10…

Stereotactic radiation outperforms hippocampal-avoidance whole brain radiation for 5–20 brain metastases. It better reduces symptoms and protects daily function. @JAMA_current @BrighamWomens @AyalAizer @OncoAlert

In localized radiorecurrent #ProstateCancer, salvage focal therapy provided similar 10-year survival outcomes as radical prostatectomy but resulted in substantially fewer perioperative complications. ja.ma/4rbkdTR

🎵 Randomized trial (N=300) of telehealth-delivered Music Therapy vs CBT among cancer survivors with anxiety shows that music therapy was non-inferior and led to durable anxiety reduction. The core of the intervention: collaborative songwriting. Fantastic. ascopubs.org/doi/10.1200/JC…

Standard esophagectomy after neoadjuvant chemoradiation may provide greater long-term survival and quality-of-life benefits than active surveillance for most patients with esophageal cancer. ja.ma/4sPlBNb

Tumor Treating Fields Therapy After Stereotactic Radiosurgery for Brain Metastases From Non-Small Cell Lung Cancer: Final Results of the Phase 3 METIS Study - International Journal of Radiation Oncology, Biology, Physics redjournal.org/article/S0360-…

☢️New meta-analysis in JAMA Network Open: 🎯Stereotactic body radiotherapy (SBRT) alone for oligometastatic cancer achieved 70% systemic therapy-free survival at 1-2 years, highest in renal (87%) and prostate cancer (78%). 🎯Low toxicity rates suggest SBRT may safely defer chemotherapy in selected patients. 10.1001/jamanetworkopen.2025.49685 @OncoAlert @DrYukselUrun #MedX #Cancer #Oncology @JAMANetworkOpen

Proton versus photon radiotherapy for patients with oropharyngeal cancer in the USA: a multicentre, randomised, open-label, non-inferiority phase 3 trial hubs.li/Q03-8-Bq0

Healthcare innovation 🎯🩺 Southwest Florida Proton has delivered its first proton therapy treatment, officially becoming the first cancer center on Florida’s west coast to offer this highly advanced and precise form of radiation therapy. Learn more: prioritymarketing.com/southwest-flor…

Benefit of Chemoradiotherapy Versus Chemotherapy After Induction Therapy for Conversion of Unresectable Into Resectable Pancreatic Cancer: The Randomized CONKO-007 Trial. Read the full article. brnw.ch/21wV1Oi #pamcsm

Nice to see this article on de-escalation: Optimal Duration of Androgen Deprivation Therapy With Definitive Radiotherapy for Localized Prostate Cancer: A Meta-Analysis | Reproductive Health | JAMA Oncology | JAMA Network jamanetwork.com/journals/jamao…

🌙LUNAR phase 2 RCT: adding Lu-177 PSMA to SABR for oligorecurrent prostate cancer significantly improved PFS without increased toxicity Just out in @JCO_ASCO: ascopubs.org/doi/pdf/10.120… Impressive trial and results @AmarUKishan @CalaisJeremie and team

Presented at #ESMO25: In high-risk biochemically recurrent prostate cancer, enzalutamide plus leuprolide significantly improved overall survival as compared with leuprolide alone. Enzalutamide monotherapy had no significant benefit for survival. Full EMBARK phase 3 trial results: nej.md/4h8QpDc @myESMO

WOW! 🧠METIS trial (n=298) in #lungcancer brain mets: SRS ➕ TTFields ⚡vs SRS alone ✅ TTFields delays intracranial progression (HR 0.72, p=0.044) 📉12-mo progression: 47% vs 59%; ⬆️ with immunotherapy (HR 0.63) ❌No QoL / cognition decline; AEs mild skin #ASTRO25 #RadOnc #lcsm

📢 JAMA Oncol (Oct 2, 2025): Phase 2 RCT: PSMA PET–guided intensification of salvage RT post-prostatectomy shows improved biochemical control vs standard RT. ➡️ Suggests molecular imaging can personalize salvage therapy. 👉10.1001/jamaoncol.2025.3625 @JAMAOnc @ONCOassist @OncoAlert #cancer #Oncology #MedX @APCCC_Lugano

"SBRT and surgery had similar 10-year outcomes, reinforcing the initial five-year data that we have previously presented from this trial," says @JoeChangMD of radiation for early-stage non-small cell lung cancer treatment. (1/2) #EndCancer

New today in #PracticalRO: Joint guideline from ASTRO, ASCO & SSO on post-mastectomy radiation therapy for patients with breast cancer. Updated recommendations cover indications, dosing, fractionation & multidisciplinary techniques. #RadOnc #BreastCancer ow.ly/524k50WXGao @ASCO @SocSurgOnc

.@JCO_ASCO Phase III RCT FLAME (n=571). Focal boost (95 Gy) + standard EBRT (77 Gy) vs standard EBRT alone for localized intermediate-/high-risk prostate cancer showed improved 10-yr bDFS (86% vs 71%). PMID:40758955 pubmed.ncbi.nlm.nih.gov/40758955/