David Diamond

I'm honored that my paper on statistical deception in cholesterol research will be the topic of a Grand Rounds Med School panel discussion today. bit.ly/3Lpo5gw @ProfTimNoakes @DoctorTro @DominicDAgosti2 @lowcarbGP @SBakerMD @ethanjweiss @davidludwigmd @DrAseemMalhotra

@realDaveFeldman @DoctorTro @LynneSaunt @robynrdobbins doi.org/10.1097/med.00…

Here is a good example of how unimportant high LDL is and how important the ratio of trigs/HDL is. This n=2 genetic study shows the importance of trigs/HDL in an FH father and son. Massively high TC and LDL were irrelevant. What mattered was the trig/HDL ratio. Healthy 84 year old father, unhealthy 54 year old son. Both with high LDL, but the son had high trigs,presumably because of his high carb diet (type B). @zoeharcombe @ProfTimNoakes @KenDBerryMD

#CholesterolCodeMovie is out with 100’s of rave reviews on Amazon, but watching it was bittersweet for me. Sweet because I have great admiration for @realDaveFeldman because he took an observation, his own elevated LDL-cholesterol on #LCHF, and turned it into a phenomenon, the #LMHR, which identified a subset of metabolically healthy people with very high LDL. The film shows the great value of the ketogenic diet for mental and physical health, treating not only epilepsy and diabetes (@drjenunwin; @drericwestman @lowcarbGP), but also ulcerative colitis, autoimmune diseases (@nicknorwitz @MikhailaFuller) and psychiatric disorders (@georgiaedeMD; @chrisPalmerMD @matthewbaszucki). It is impressive that Dave worked with cardiologists (@BudoffMd @AdrianSotoMota) to secure funding to study the arteries of 100 LMHRs, which found no association between their LDL-C/ApoB levels and the extent of their plaque. This is a truly remarkable feat especially considering Dave is an outsider to medical research. For this accomplishment Dave deserves massive kudos. The bitter part for me is how the fear of high LDL pervades the documentary. Dave interviewed some MDs about this issue, e.g., @bscherMD, @DoctorTro, Arthur Agatson, MD, and they expressed mild skepticism about the importance of cholesterol in causing heart disease. However, they left it unresolved as to whether metabolically healthy people on a ketogenic diet may suffer an early death from heart disease because of their high LDL. I was dismayed to see that one #LMHR with a ketogenic diet-induced remission of her depression symptoms added carbs to her diet to “improve”, i.e., lower, her LDL. When her depression returned with the reintroduction of carbs, she reluctantly eliminated the carbs, accepting the possibility that the keto diet resolved her psychiatric condition, but at a cost of raising her LDL and therefore increasing her risk of developing heart disease. Similarly, the type 1 diabetic boy on keto diet had very high LDL, and the issue that was left unresolved as to whether this metabolically healthy child will die of heart disease at an early age. To his credit, Dave raised the issue of the greater risk of heart disease from insulin resistance compared to high LDL. Nevertheless, LDL was still presented as a biomarker of great concern. What I found disappointing is that Dave traveled the world to interview people, but he didn’t speak with even one of the many MDs and scientists that have challenged the notion that high LDL/ApoB, alone, is atherogenic. Some of those MD/scientists are Uffe Ravnskov, MD, Malcolm Kendrick, MD, Folkert van Bruggen, MD, Paul Rosch, MD, Nadir Ali, MD, Michel DeLorgeril, MD, Sherif Sultan, MD, Blair O'Neill, MD, @BenBikmanPhD @DrPaulMason @Alabdulgaderaa @ifixhearts @FatEmperor @zoeharcombe @ProfTimNoakes @MaryanneDemasi @SinatraMD @DwightLundell and others, including me. It is unfortunate that so many people who have systematically reviewed the literature, many of whom have published papers and books addressing LDL concerns and have concluded that the fear over high LDL is not justified, were not invited to share their findings in the film. There were aspects of LDL concerns expressed in the film that could’ve been addressed by any of the MD/scientists mentioned above. For example, Dave stated that people with the rare genetic anomaly, familial hypercholesterolemia (FH), who have extremely high LDL from birth, have heart attacks and death in young children. He further noted that “FH is the strongest case to support the hypothesis that LDL independently causes heart disease”. However, it has been repeatedly shown that, as a group, people with heterozygous FH have a normal lifespan (which preceded statin development). It has also been shown that elderly FH people have a lower rate of death from cancer and infection, and a normal rate of CVD death, compared to the general population. What about the people with FH who die young? We have published papers demonstrating that the FH individuals who experience coronary events at an early age have high levels of clotting factors, independent of their LDL level. Homozygous FH, which has been characterized solely as a lethal extremely high LDL disease, is similar to heterozygous FH because it is also a disease that includes a high level of at least one clotting factor (fibrinogen), which may explain why these people die young. The potential deleterious actions of excess clotting factors in people with homozygous FH has been ignored in favor of blaming their premature death on their high LDL. It is unfortunate that the highly atherogenic effect of hypercoagulation, in the FH population as well as the general population, was not addressed in the film. Finally, what was also not addressed in the film is the evidence that metabolically healthy (LMHR-like) people with high LDL have a much lower rate of coronary events than metabolically unhealthy people with equally high LDL. It was also disappointing to me to see in the film that one #LMHR takes a statin despite the finding that there is no benefit of statin treatment in metabolically healthy (LMHR-like) people with very high LDL. Some of these findings are provided in my presentation at Dave’s #CoSci meeting: youtube.com/watch?v=BWxMKi… Once again, I’m a great admirer of Dave Feldman and all that he has accomplished with his personal journey addressing his own high LDL on #LCHF and his study of LMHRs. However, in my opinion, the #CholesterolCodeMovie should’ve had 3 components. The first is the great benefit of the ketogenic diet for mental and physical health. The second is the concern with extremely high LDL in a subset of people following the keto diet. The third should’ve been perspectives from world-class scientists explaining why high LDL in metabolically healthy people would not be expected to cause CVD. It is unfortunate that only the first two components were included in the film, leaving the issue of concerns with high LDL, and why LDL did not correlate with arterial plaque, unresolved. @DiljanMansoor @markkaplan20 @KenDBerryMD @PeterJAnderson_ @ApoDud @dramerling @ElieJarrougeMD @JeffryGerberMD @TuitNutrition @bigfatsurprise @GrassBased @shashiiyengar @drozcanyuce @SbakerMD @DominicDAgosti2 @ElieJarrougeMD @grahamsphillips

Doctor: I'm concerned about this carnivore diet you've lost two stone on. Patient: How concerned. Doctor: Your LDL is elevated. Patient: Triglycerides? Doctor: Low. Patient: HDL? Doctor: High. Patient: Inflammatory markers? Doctor: Pristine. Patient: Blood pressure? Doctor: Textbook. Patient: Resting heart rate? Doctor: 52. Patient: Body fat? Doctor: 12%. Patient: A1C? Doctor: 5.0. Patient: So what's the problem. Doctor: The LDL is elevated. Patient: I see. Patient: Have you considered that your single marker is failing to capture the situation. Doctor: We don't really go in for that sort of thinking.

@onphel @robynrdobbins @realDaveFeldman @DoctorTro @eatmostlyfatali @malcolmken 👏🙏

@LDLSkeptic @robynrdobbins @realDaveFeldman @DoctorTro You, @LDLSkeptic, Dr. Ali, @eatmostlyfatali, and Dr. Malcolm Kendrick, @malcolmken, are my heroes. I wondered why the three of you have not been on Dave's recent podcast. Thank you for all you do.

Standard disclaimer: do not take my advice. Before eating the foods your species ate for 2.5 million years, check with your overweight doctor your vegan dietician, or the guidelines that recommend margarine over butter and call sugar an essential macro. They have your best interests at heart. The heart they're medicating with three different statins.

So many people deny that I reversed plaque and healed my heart without medications after my heart attack. I just posted a video showing all my imaging. Please share, and subscribe to my YouTube channel if you feel so inclined. youtu.be/Yj_DFJUmQ80?si… @anthony_chaffee @SBakerMD @paulsaladinomd @realDaveFeldman @nicknorwitz @LDLskeptic2 @ProfTimNoakes @malcolmken @FatEmperor @ifixhearts @AnnetteBosworth @DrPaulMason @ketosavage @MikhailaFuller @DrSeanOMara @ThePrimal_Pod @drericwestman @bulletproofexec

Two dietitians reported a doctor for telling diabetics to eat butter. Two years later, the government sided with the doctor. Dr. Annika Dahlqvist. Family physician in northern Sweden. She started recommending low-carb high-fat eating to her overweight and diabetic patients. They lost weight. Diabetics dropped insulin. Some came off medication entirely. Two dietitians did not like that. They filed a malpractice complaint with Sweden's National Board of Health and Welfare. The charge: recommending fat to diabetics endangered their lives. The Board could revoke her license. Her own clinic fired her in November 2006. She spent two years in professional limbo. The Board reviewed the science. Slowly. While Sweden's diabetes and obesity rates kept climbing. January 2008. The verdict came back. Dr. Dahlqvist had done nothing wrong. The Board ruled, in writing, that low-carb high-fat eating was fully compatible with current science. The dietitians wanted her shut down. The science shut them down instead. That single ruling cracked Sweden open. LCHF spread through the country in a way it had nowhere else on earth. Kostdoktorn (Diet Doctor) was founded the same year. Within a decade, surveys showed roughly one in four Swedes had tried low-carb. It is now one of the most popular diets in the country. When two dietitians filed that complaint, they thought they were ending her career. They were starting a movement. #AnnikaDahlqvist #LCHF #LowCarbHighFat #DiabetesReversal #Sweden #DieticiansVsScience #FoodIsMedicine #RealFood #ButterNotMargarine

Blood pressure targets are too low. Treating mild hypertension, BP up to 159/99: -No improvement in mortality, or risk of cardiovascular (CV) events. Severe hypertension, over 160/100: -Reduces CV events and mortality, but number needed to treat is 24 and 83.

If you’re truly worried about heart disease, stop “blaming the butter for what the bread is doing.”

Butter is genuinely incredible. Cook your steak in it. Cook your eggs in it until it pools around the yolks like a small golden lake. Slather it on liver. Stack a slice on top of mince so thick the pan starts to feel embarrassed. Stir a knob through the pan juices. Roast a chicken under it. Brown it gently and pour the foaming brown butter over the ribeye, crust crackling, salt optional. Use it as a condiment. Yes. As a condiment. Have a small dish of butter on the table the way some households have salt. Eat it off a knife at 11pm when nobody is watching. Eat it off a knife at 11pm when somebody is watching, and look them in the eye. Pack a small block in your luggage. Customs will have questions. The questions are not really about the butter. Use it to bribe a magistrate. Anoint a relative on their birthday. Build a small altar in the corner of the kitchen and place the salted block at the centre. Send a stick of butter to your enemy in the post. Receive theirs in return. Stalemate. Both kitchens win. Trade a wheel of it for safe passage through a checkpoint. Slip a pat under the tongue of a sleeping rival. Smear it on the doorframe to ward off the dietician. Leave a small offering by the back gate for the goat. The Celts buried it in bogs for two thousand years and dug it up still edible. The French built a cuisine around it. The Tibetans put it in their tea. The Indians clarified it and gave it a holy name. You were told to be afraid of it by a margarine company in 1977. Have a think about who benefited from that. Eat the butter.

Insulin Resistance Is 6X More Dangerous Than High Cholesterol Most people are focused on cholesterol but according to heart surgeon Dr. Philip Ovadia, insulin resistance is a far more powerful predictor of heart disease risk. Measured by the LPIR score, insulin resistance creates a 600% increased risk of developing heart disease, dwarfing the risk of simply having elevated cholesterol levels. The good news? You can start managing insulin resistance today by lowering your carbohydrate intake. Save this and share it with someone still blaming cholesterol for their heart health issues! Watch full video here! 👉 youtu.be/2GZkwKsF1Qs?si…  #InsulinResistance #HeartHealth #CholesterolMyth #MetabolicHealth #HeartDisease

BOOM Chlorine Dioxide was Suppressed. Dr. Pierre Kory just dropped the bomb: Chlorine Dioxide (CDS) isn’t some fringe hack — it’s the cheap, universal antidote they don’t want you to know about. Wiped out COVID cases in Bolivia. Hospitals emptied. ICUs went silent. Kills viruses, bacteria, parasites, cancer cells — yet costs under $30 for a TWO-YEAR supply. They buried the studies. Silenced the doctors. Ran the same playbook as Ivermectin in India. Dr. Kory says if he gets COVID tomorrow? CDS is his #1 choice — hands down.

@LDLSkeptic @realDaveFeldman Thank you for saving me the time and irritation of watching. Unbelievable that the great lie was danced around when the "high ldl/apob hypothesis" has been buried time and again by many great minds including yours. What a fiasco and waste of time, literally can't believe it.

@_coach_al @realDaveFeldman Thanks Al Very well stated

Extremely well said, David. Honestly, I had somewhat of the same feeling or conclusion. Of course, I appreciate all Dave F. and his team have done to ask new important questions and highlight important facts about LDL, but still. The problem comes back to this one fact: the dogma surrounding the diet-heart hypothesis and LDL as a causal risk factor (in and of itself) for CVD, is SO PERVASIVE, so strong, so embedded in modern medicine and in the minds of most people walking the planet, it will take decades...to turn the tide even under the best of circumstances. Some of the names you mentioned should have been included. It's time to call a spade a spade.

Familial Hypercholesterolemia: LDL levels do not correlate with levels of cardiovascular disease. Coagulation factors, are the true drivers of increased CVD. LDL is not the problem. -Statins are the not the answer.

@amyalkon @realDaveFeldman 🙏🙏🙏

@LDLSkeptic @realDaveFeldman Thank you, thank you, thank you!

@LDLSkeptic @realDaveFeldman This is why I would not be inclined to promote the film among friends and family, some of whom are doctors & all who may be concerned about issues surrounding LDL. Stoking fears without presenting answers as DD has suggested would just I feel do more harm than good. What a shame.

@DrJColeridge @realDaveFeldman 🙏