David Diamond

I'm honored that my paper on statistical deception in cholesterol research will be the topic of a Grand Rounds Med School panel discussion today. bit.ly/3Lpo5gw @ProfTimNoakes @DoctorTro @DominicDAgosti2 @lowcarbGP @SBakerMD @ethanjweiss @davidludwigmd @DrAseemMalhotra

Dr. Annette Bosworth revealed she didn't give her mother chemo when she had cancer. She put her on a strict ketogenic diet instead. And six weeks later, her mother's cancer markers dropped by 70%. Her mother's oncologist was baffled: "How did you get her numbers to drop by 70%? There's no drug on the market that would do that." The science behind it is ketones from the keto or "low-carb" diet. Cancer cells rely heavily on glucose for energy. When you drastically cut carbohydrates, the body switches to ketones for fuel. Healthy cells can use ketones efficiently. Many cancer cells cannot. In Dr. Bosworth's words: "She went from a 70-year-old that looked 100 to a 75-year-old who looked 40." Her mother went back to volunteering, teaching Sunday school, and living her life fully - until COVID took her years later. The ketogenic diet didn't cure her cancer. But it gave her back the years that mattered most. — Dr. Boz on Steven Bartlett's (@StevenBartlett) DOAC podcast

@ChristofferBN Every post of yours on LDL is pro-statin (pro-LLT) and LDL causes CVD (correct me if I'm wrong). I'm wondering why you are so committed to the lipid hypothesis. Are you a lipidologist or cardio doc or do you benefit $ from lipid lowering. Your mind seems closed on the topic.

@LDLSkeptic Not completely sure what a drug rep even is. Anyway, would appreciate it if you would kindly respond to my argument instead of talking about something else. Thanks.

"Genotypes that produce lifelong differences in fibrinogen concentrations do not materially influence CD incidence... genetic results provide strong evidence that long-term differences in fibrinogen concentrations are not a major determinant of CD risk." pubmed.ncbi.nlm.nih.gov/16870675/

Fifty years. One paid review. That’s all it took. 1965A sugar trade group needs the science to look a certain way. They hand-pick the studies. They hire three Harvard scientists. They pay them the equivalent of fifty thousand dollars today. The scientists write the review the sugar industry wanted. Sugar is cleared. Saturated fat takes the blame. An executive writes back after reading the final draft. This is quite what we had in mind. 1967The review runs in the New England Journal of Medicine. No funding disclosed. No conflict of interest listed. The journal did not even require it back then. That single paper helped build the foundation for the low-fat advice that followed for the next five decades. Butter became the enemy. Bread became the hero. A nation was told to fear the wrong food. One of the three paid scientists went on to help write the first official US dietary guidelines in 1977. The correspondence sat buried in a box in a Harvard library for 49 years. A researcher found it in 2016. The letters. The drafts. The payment. Published in JAMA, in black and white, decades after every person who wrote them was already dead. Fifty years of guilt over butter and cream. Paid for by the people who profited from the sugar. Share this. Someone in your circle still believes the fat on their plate is what is killing them.

@SamaHoole @grok - Is this post accurate?

California grows around 90% of the strawberries eaten in the United States, and before a single plant goes in the ground, the field is poisoned on purpose. The soil is fumigated. Growers inject chemicals like chloropicrin into the earth to sterilise it, killing the fungi, the insects, the nematodes, the weeds, everything alive in it, so the strawberry can be grown in what is effectively dead ground held up by synthetic inputs. This is done to most of the state's strawberry acreage, every planting cycle. Chloropicrin was first used to choke men in the trenches in 1917. It is now pumped into the ground your dessert grows in, year after year. The people who inject it and work its drift zone are farmworkers, many undocumented. California's own regulators rank these fumigants among the top causes of pesticide illness in the state, hitting the eyes, the lungs, the nerves. Drift near the fields has been bad enough to send schoolchildren home from class. The strawberry is sold as the wholesome one. Antioxidants, heart health, plant-based superfood, the red thing in the clamshell twelve months a year, including the depth of winter when nothing in that hemisphere should be fruiting. They sterilised the ground with a weapon from Ypres to grow you a heart-healthy berry, and the man holding the injector can't afford a doctor.

@HalCranmer This is an unpublished, unreviewed manuscript from 2025. Has it been published yet?

45 million Americans alive today will die of Alzheimer's, and they have no idea it can be reversed. A 2025 clinical trial found 90% of people in the treatment group improved their mild Alzheimer's, with a few fully recovering. This is the full breakdown of the study:🧵

HoFH is so rare there's very little known about it. HoFH just like HeFH have increased clotting factors and a great propensity to clot. So we just don't know if it's high LDL, alone, high LDL interacting with clotting factors, or clotting factors alone that matter for FH lifespan.

@LDLSkeptic @realDaveFeldman @MurseDarius OK, 40 on average, but if we are talking hetero vs. homo don't the homozygous untreated die very young while the hetero more like 40-50's?

1/20 The film Cholesterol Code is going Global tomorrow. The most important aspect of the film is the documentation of the great benefit of the ketogenic diet (KD) for mental and physical health. What is unfortunate is that the film leaves the viewer with the impression that nothing is known as to whether people on a KD with high LDL are at increased risk of developing cardiovascular disease (CVD). While no one can say for certain whether high LDL in a metabolically healthy person increases the risk of CVD, what is so terribly disappointing is that the film lacks any scholarship regarding the LDL literature. I am therefore going to share what I think is missing from the film. @BenBikmanPhD @DrPaulMason @Alabdulgaderaa @ifixhearts @FatEmperor @zoeharcombe @ProfTimNoakes @MaryanneDemasi @SinatraMD @DwightLundell @DiljanMansoor @markkaplan20 @KenDBerryMD @PeterJAnderson_@ApoDudz @dramerling @ElieJarrougeMD @JeffryGerberMD @TuitNutrition @bigfatsurprise @GrassBased @shashiiyengar @drozcanyuce @SbakerMD @DominicDAgosti2 @ElieJarrougeMD @grahamsphillips @doctortro @bscherMD @BudoffMd @AdrianSotoMota @drjenunwin @drericwestman @lowcarbGP @_coach_al @nicknorwitz @lowcarbGP

People often ask me how I can eat so much butter and I’d like to make a confession about it. You see, I have a rare condition. My body doesn’t naturally produce its own butter, so I have to consume it exogenously. Every. Single. Day. And I feel like garbage if I don’t. It’s called Butter Deficiency Syndrome. Please help support BDS. If you’d like to help fund my treatments, donations to my tip jar are greatly appreciated. Thank you for your generosity!

In October, Erling Haaland pulled up at a tiny Cheshire dairy on his way to training and filmed himself buying raw milk, beef and honey. The farm, a micro dairy called Greenoaks that sells unpasteurised milk straight from the gate, could not keep up with the orders once the video reached his millions of subscribers. But Haaland was never really the story. He calls raw milk his magic potion and swears it is good for the stomach, skin, bones and muscles, yet he is only the loudest voice in something that had been building for years before he picked up a bottle. Look at the numbers. Raw milk sales in America jumped more than twenty percent in a single year, and in the peak weeks as much as sixty five percent. In that same year, sales of the plant based milks fell. Roughly eleven million Americans now drink it raw, states from Oklahoma to Arkansas have torn up the rules that held it back, and the biggest raw dairy farmer in the country says that whatever the FDA tells his customers not to do, they go and do the opposite. Here is the tell. In the middle of all this warning, the agencies sounding the alarm quietly cut their main food safety network from tracking eight germs to two, and two of the ones they stopped counting are the exact bugs they say make raw milk dangerous. Understand what you are watching, because it is bigger than milk. This is the generation switched from butter to margarine by experts who later shrugged, told eggs would stop its heart and then told they were fine, frightened of the fat on a steak for forty years. It has done the arithmetic on how often the warning was the actual mistake, and stopped waiting for permission. The man now in charge of American health drinks his milk raw. The public looked at the men still standing after every other warning collapsed, and started buying it by the gallon. One video sold out a Cheshire dairy. The warnings stopped working the day the people issuing them ran out of credibility.

Kan açlık insülininizi ve HOMA-IR değerinizi değerlendirmeden, yalnızca LDL düzeyinize bakarak: “Kolesterol ilacını almazsan ölürsün.” şeklinde yapılan kesin yargılardan uzak durun. Kardiyovasküler risk belirlemede LDL’nin olumsuz nerdeyse hiç bir katkısı yoktur!! Yüksek kolesterol düşürülmesi gereken bir şey değildir!!!

Dave - @realDaveFeldman and @nicknorwitz have shown that you can move LDL-C up and down based on carbs in the diet. You've replicated their findings. Whether it has any effect on health outcomes is unknown, except with carb addition you may lose benefits of the keto diet. IMO, there's no empirical evidence to justify lowering LDL no matter how high it is.

@LDLSkeptic David, I went low carb previously for general health 2021-25 and LDL-C went to ~ 250 mg/dL. I since reintroduced whole food carbs, reduced fat, and LDL-C dropped to 130 mg/dL. If I have good health either way then mixed macros seems to make sense. Thoughts?

@NeilXJohnson @ApoDudz @CRYPT0N1TE @realDaveFeldman @MurseDarius @trikomes Neil - That certainly is possible and is related to Harlan et al's finding in 1966 of a normal lifespan for FH people.

I'm curious for the opinion from those who advocate that environmental / PUFA explain 100% of the FH susceptibility to heart disease. E.g. Seed oil, leaded gasoline, smoking, heavy metals, trans fatty PUFA (Enig Kummerow) etc.. Soy and canola are high in TFA PUFA. @trikomes @TuckerGoodrich

Austin - If the non-statistical ACM effect was based on a statin-induced reduction in CVD mortality I would agree. But Mundal et al also showed a significant CVD mortality in FH which persisted into their 60's. So there is no evidence statins reduced CVD FH mortality and therefore did not influence ACM. Also, the 20-year pediatric work is useless to me because it compares modern FH children's deaths to adult deaths from decades before, as overall CVD deaths declined in the general population.

David — wouldn’t you surmise some of the contribution to these trends are a product of LLT given this registry was in the statin era? To be clear, I’m not making this claim but it seems plausible, no? Any feedback welcome. Curious how you weigh the long-term FH statin trials (e.g., the 20-year pediatric data) against the registry limitations? I don’t want to discount the catastrophic nature of smoking, HTN, IR in the context of FH but it seems LLT likely has some benefits and contribution to the trends your cited data, no? And unfortunately, despite my best efforts 🤣 , not everyone wants to change their lifestyle and in those circumstances or even with those who changed their lifestyle, LLT is reasonable if the patient is agreeable with close monitoring, no?

You ate this morning one of these two breakfasts. Your doctor told you the wrong one would kill you. He had it backwards for 50 years. The breakfast on the left causes Type 2 diabetes. Type 2 diabetes carries 10x the heart attack risk of the cholesterol he watches. The breakfast on the right does not move your blood sugar. He fed you the heart attack diet and told you it was heart-healthy.

If this reached you, send it to someone who needs it. Someone on a statin. Someone on metformin. Someone injecting GLP-1 once a week. Someone whose doctor has never tested their fasting insulin. The root cause is measurable. Treatable. And almost entirely ignored. Our medical doctors and science community Dr. Philip Ovadia, Cardiac Surgeon @ifixhearts Dr. Aseem Malhotra, Cardiologist @DrAseemMalhotra Dr. Robert Cywes, PhD Metabolic Surgeon @carbaddictiondr Prof. Tim Noakes, Head of Science @ProfTimNoakes David Diamond, PhD @LDLSkeptic Nina Teicholtz, PhD @bigfatsurprise The truth heals

New RCT: Vitamin K2 (MK-7), 360 mcg/day for 2 yrs, slowed coronary artery calcification ~29% vs placebo. Effects were seen at both 1 & 2 yrs, in both calcium score & calcium mass. They should be doing RCT's exploring higher doses as well--One serving of natto has 500 mcg.

@SamaHoole Looks like Ancel Keys, purveyor of misinformation, second from the right

In 1948 the American Heart Association was a small, broke society of cardiologists, the kind of outfit that struggles to pay for the room it meets in. Within a decade it would be the most powerful voice on the American dinner table, the body whose blessing decided what a nation spread on its bread. The thing that lifted it happened on the radio, and it came from a soap company. The soap company was Procter and Gamble, and it had a product to move. In 1911 it had launched Crisco, and Crisco was cottonseed oil, which until then had been an industrial waste, a throwaway of the cotton mills fit for making soap and lamp fuel and little else. P&G took that waste, forced hydrogen through it until it set into a white grease that looked like lard, and sold it to housewives as cleaner and more modern than the butter and dripping their mothers had used. A hardened factory oil, a chemistry trick, the birthplace of the artificial trans fat that would later be found to wreck the very hearts in question. That was the product hunting a friendly authority. The show was Truth or Consequences, a national hit, and its host Ralph Edwards ran a contest that spring, the Walking Man, sponsored by Procter and Gamble. More than two million letters came in. The pot came to around one and three quarter million dollars, something like twenty million today, and Procter and Gamble named who got it. The American Heart Association. By the AHA's own history that was the making of them. The bang of big bucks, one insider called it. Overnight the empty coffers were full, seven chapters opened inside a year, and the newly mighty body went on to spend the next half century telling Americans to put down the butter and reach for the vegetable oil. The charity that taught a nation to fear animal fat was built by the men selling the hydrogenated waste that replaced it. The science was bought before the first study was ever run.

RFK Jr: "In a million years, I would not take the flu shot—and I'll tell you why." "The flu shot primes you for flu, 36% pathogenic priming for COVID & increases non-flu infections like pneumonia 440%." Here’s the evidence—ingredients, studies & stats that demand your attention. 🧪 Toxic Ingredients in Flu Shots: • Formaldehyde – known carcinogen • Fall Armyworm ovary - growth medium & allergen. • Polysorbate 80 – crosses blood-brain barrier, linked to infertility. • Neomycin – antibiotic that triggers severe allergies • Egg proteins & dog kidney cells – allergens + foreign DNA fragments • Squalene M59(in adjuvanted shots) – tied to Gulf War Syndrome autoimmune reactions 🔬 Key Studies Exposing the Harms: • Cochrane Review & Cowling et al. (2012): Flu shot increased non-flu respiratory infections 4.4X of COVID & pneumonia, that's a 440% increase! • Pentagon Study (2017–2018): Flu-vaccinated troops had 36% higher odds of coronavirus. • Skowronski et al. (2009): Confirmed vaccine enhanced disease. • Multiple meta-analyses (2022): Show interference & heightened risk for certain strains. 📊 Shocking Statistics: • VAERS (as of 2025): 235,818 adverse events, 1,024 hospitalizations, massive underreporting. • Guillain-Barré Syndrome: 1 in 1 million doses (WHO) • Vaccinated kids: 4.4X more likely to catch other respiratory viruses. • Military personnel: 36% increased coronavirus risk after flu shot. Your immune system is smarter than Big Pharma’s guesses. Build it with nutrition, not needles.

I see from your posts that you're completely devoted to the lipid hypothesis - that LDL causes CVD. Not sure why - maybe you're a drug rep. Once you pull the curtain away from relative risk benefits of lipid lowering and realize there's barely any absolute risk benefit despite massive LDL reduction, you should start thinking about how you've been misled.

@LDLSkeptic An adjusted effect says nothing about whether an interaction exists. Adjustment removes confounding, not interaction. That the effect vanished when adjusted for means fibrinogen is likely a marker. Interaction is a different q & it's tested in a different way (stratification).

@CRYPT0N1TE @realDaveFeldman @MurseDarius thanks BTC but it's not correct that 50% of FH die before 30 - actually the % that die before 30 is low and not statistically significant

@realDaveFeldman @LDLSkeptic @MurseDarius His point is valid. By all laws of logic you can not have FH patients with lifelong >350 LDL and 50% die before 30 and the other 50% live without CVD to 80+. It CAN'T be the LDL. If people get shot in the head with a 9mm, do 50% of them not even get a scratch? NO not how it works

Fructose is the only sugar that raises uric acid the moment it hits the liver. No other food does this. Not glucose, not fat, not protein. Fructose gets phosphorylated by an enzyme called fructokinase, and unlike glucose, that reaction has no brake on it. It burns through the cell’s energy so fast that ATP drops, and that drop is what triggers the breakdown of purines into uric acid. This is not a side effect. It is the direct, immediate metabolic signature of fructose and nothing else. For most of human history fruit was seasonal, available for a few weeks a year at most. Now it is available fresh, dried, juiced, and concentrated, every single day, all year round. The body still runs the same fructokinase pathway every time, uric acid rising with it, regardless of season. Nobody mentions this when handing out the advice to eat more fruit.