Lyssiotis Lab

🚨New @LyssiotisLab paper led by Dr. Megan Radyk in @NatureMetabolism "NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions" 🧵Follow for a tweetorial... and bonus highlight of @LabVousden co-published study and News & Views link from @WellenLab!

Highlighting the work we do everyday in this fight! Thank you, Dr. Rashmi Kumar @timofran1 @Pasca_Lab @LyssiotisLab @UMRogelCancer @UMichSurgery youtu.be/tUxWje2DhoQ?si…

The hill I will die on - we have to rethink graduate training. “Scientists are trained for a world where data speaks for itself. Where misinformation moves slowly. Where scientific expertise naturally rises above noise. That world is gone.” sciencepolitics.org/2026/03/18/wer…

@shouval_lab @SnehaPramod @hagargir and I reflect on the work of the ✨ TME community in a new review re fibroblasts in cancer @NatureCancer. 2025 was my yr to 🩵 the distraction of writing (IYKYK), so thx to all whose discoveries made this so gratifying. nature.com/articles/s4301…

American science continues to shrink despite the story being told to the public. And it’s the long term consequences that will be most devastating.

As a pancreatic cancer doc, cannot understate the gravity of this moment. I get chills at the prospect that we will imminently have something else to offer our patients with real clinical impact. @AACR #AACR26 @RevMedicines

An unprecedented number of US scientists are trading in their lab coats to run for office in the US mid-term elections in November. go.nature.com/3QePI1Q

Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s4155…

Fortunate to share in the visit with translational science superstar, Dr. Jen Jen Yeh, Director, UNC Lineberger Pancreatic Cancer Center of Excellence. Dr. Yeh was the Dept. of Surgery Grand Rounds speaker on April 16th hosted by Dr. Frankel and the Center for Basic and Translational Science (CBATS). @timofran1 @LyssiotisLab @Pasca_Lab @UMichSurgery @Fil_Bednar

Exciting Work! Science driving progress! pancan.org/news/first-ras… @timofran1 @Pasca_Lab @LyssiotisLab @UMRogelCancer

That's right. Inflammation is the big miss for getting ahead of coronary artery disease scientificamerican.com/article/new-ev… My review of this big shift erictopol.substack.com/p/the-big-shif…

What are GLP-1s actually doing? In my latest for the @nytopinion, I explore how patients experience these drugs & why the story may be more complex than many assume. nytimes.com/interactive/20… feat. insights from @DanielJDrucker @seeleyrj @BevTchangMD among many others #glp1

An update from University of Michigan Board of Regents Chair Mark J. Bernstein about the presidential transition.

University of Michigan President-Elect Kent Syverud has been diagnosed with brain cancer and will not be the university's 16th president. He is receiving treatment at the university's hospitals, per statement.

The University of Michigan joins the Forbes New Ivies list, blending a 16% acceptance rate with a world-class research curriculum. From its "Making the Most of Michigan" course to 50 national athletic titles, the university produces the high-achieving graduates employers demand. As a result, they've been listed on the #ForbesNewIvies list: forbes.com/sites/aliciapa…

Our review dissecting the nuanced roles of mitochondria during cancer progression was just published in @AnnualReviews of Cancer Biology. This was driven by grad student David Sokolov, who wrote it in an approachable and entertaining style. Check it out: annualreviews.org/content/journa…

Agree 100% with @BenSasse! "The purpose of a trial is not the individual care of a single patient, but the benefits of getting data to advance the next generation for clinical care." In his case, wonderful to see the striking individual response as well. statnews.com/2026/04/14/ben…

#Throwback REVIEW | C Dibble et al. Coenzyme A biosynthesis: mechanisms of regulation, function and disease dlvr.it/TRzBW1

@JustinPerryPhD @Nature @NIH Sorry Brother 😞 Just keep doing the good work

Step 1: spend startup etc to make new mice, develop new tools, etc Step 2: submit for R01 (x2) - ND & non-funded Step 3: publish paper in @Nature Step 4: get prestigious Foundation grant (more soon!) Step 5: submit similar grant, but as @NIH R01. Result? Not discussed 🤦‍♂️🤷‍♂️

6/ Congrats to leads: @mbah_nneka & Damien Sutton! Thanks to collaborators, supporters, and funders 🙏 @UMICHpancreas, @UMPhysiology, @UMRogelCancer, @YatrikShahLab, @_Hanna_Hong, @Pasca_Lab, @timofran1, @theNCI

6/ In summary, while we potently induced ICD DAMPs in vitro, these did not translate to ICD in vivo. These findings suggest that, on balance, the effects of ferroptotic tumor cell death help to establish a tumor-protective, immune-tolerant microenvironment in murine PDAC.

New study from the lab 🧵 1/ Pancreatic cancer is metabolically rewired and profoundly immunosuppressive. @mbah_nneka asked: can targeting amino acid metabolism trigger immunogenic cell death (ICD) to boost anti-tumor immunity? Key twist: ferroptosis shows ICD-like signals in vitro, but is largely tumor-protective in vivo. rdcu.be/fc55T