Nick Tschernia, MD

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Nick Tschernia, MD

Nick Tschernia, MD

@NickTscherniaMD

Doctor of Hematology/Oncology • Physician-Scientist Early Investigator at NIH • Tweets are my own. He/him #Immunotherapy #CellTherapy #Cancer

Washington, DC Katılım Eylül 2020
470 Takip Edilen313 Takipçiler
Nick Tschernia, MD
Nick Tschernia, MD@NickTscherniaMD·
With ⬆️ healthcare costs, exp access to - & indications for - cell tx, and growing longitudinal data - we ask what duration of followup is scientifically reasonable? Proud to have been part of this academic, industry, & gov collaborative. @jitcancer doi.org/10.1136/jitc-2…
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Nick Tschernia, MD
Nick Tschernia, MD@NickTscherniaMD·
@AppleHelix A point lost in this debate is these are faster (wks not 5-6 months) to make w/o egg adapted muts weakening efficacy. In the event of a strong, unanticipated, ag drift ala this last season (H3N2 subclade K) we can pivot. If they're equiv to superior in ILI reduction, fantastic.
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Jing Liang 🇺🇦
Jing Liang 🇺🇦@AppleHelix·
Please think more before tweeting: Both arms were vaccinated. Not seeing deaths from a >40K head-to-head trial is a good thing! You can not use the fact that vaccines WORKED (in both arms) and use low number of hospitalizations and NO DEATHS to criticize the relative effectiveness of vaccines. A head-to-head trial powered to show stat sig difference in deaths will be impossibly big! The data from this trial demonstrated that. To satisfy Venk, he wants to see a >300K trial powered to show stat sig mortality differences in a SINGLE flu season. And he definitely doesn't want to see placebo as a comparator (if he agrees with VP's position that proper comparator should be HD)
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Nick Tschernia, MD
Nick Tschernia, MD@NickTscherniaMD·
@matthewherper This concern about comparators would have more credibility if there was any expressed interest in this past flu season where we had quality CDC and UK data that the std dose egg-based shots were poorly matched & the recombinant/cell based were superior shots this season
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Matthew Herper
Matthew Herper@matthewherper·
As several people have noted: Moderna DID run an immunogenicity study with the high dose flu vaccine. But they did not do this in the pivotal trial as the FDA requested. I think the point still stands. Here is the study they did run: clinicaltrials.gov/study/NCT05827… (And yes, I also think the existence of that study does matter with regard to whether FDA should at least have reviewed Moderna's application.)
Matthew Herper@matthewherper

I have questions for both sides on the Moderna/FDA story. (1) FDA/Vinay Prasad defenders: Even if you think Moderna should have used a higher dose comparator for people over 65, don't you think its wrong to deny an effective vaccine to people aged 50-64? (2) Moderna defenders: Don't you think Moderna should have compared to the best vaccine for people ages 65 and up? Bonus question: Are these questions that should result in the application not being reviewed, or issues the FDA should have grappled with in the review process? $MRNA $PFE

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Nick Tschernia, MD
Nick Tschernia, MD@NickTscherniaMD·
@DrEricDing Largely agree but one big caveat, the UK program prioritizes the recomb & cell based flu shots which have sup neutralization of subclade K. US largely get egg based as 1st line (2024 Medicare FFS data show 0.19% and 0.04% were cell & recomb). Not readily comparable this season.
Nick Tschernia, MD tweet mediaNick Tschernia, MD tweet media
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Eric Feigl-Ding
Eric Feigl-Ding@DrEricDing·
🧪FLU VACCINE EFFECTIVENESS—Everyone is asking if flu vaccine works this year or not… short answer is YES. Long answer—UK Health Security Agency (UKHSA) report that the 2025/26 formulated vaccine is currently ~75% effective at preventing Emergency Room visits and 73% hospital admission in children aged 2 to 17 years, while 30 to 40% effective in adults for ER and hospital admissions. Not perfect but still decent for adults, and great for kids. But why is there a vaccine-flu partial mismatch? New H3N2 VARIANT of Subclade K. So… at the end of the southern hemisphere (SH) 2025 influenza season and the start of the northern hemisphere (NH) 2025/26 season (ie too late to remake this year’s vaccine formula), a rapid increase in influenza A(H3N2) subclade K (formerly J.2.4.1) incidence was observed, with subclade K projected to dominate among H3N2 viruses during the 2025/26 season [1-3]. This marks a notable A(H3N2) virus evolution after the current seasonal 2025-26 vaccine strains were selected (based on the J.2 subclade). ➡️Do not let anti vaxxers try to tell you vaccines don’t work at all. They do by LOWERING YOUR RISK, even with mismatch it still lowers your risk by a lot, especially for kids! Get your flu shot. Tell your family and friends. 🙏 #html_fulltext" target="_blank" rel="nofollow noopener">eurosurveillance.org/content/10.280…
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Tatiana Prowell, MD
Tatiana Prowell, MD@tmprowell·
So much respect for this family. Every year they educate the public about the risks of the #flu. What a courageous & generous response to the #grief of losing their toddler. Jude is still raising awareness & saving other kids. 🙏❤️‍🩹 Please RT. #GetVaccinated #ForJudeForEveryone
Jill Promoli@jillpromoli

In response to these children's deaths, I've seen people refuse to believe they died from flu, suggest the children had comorbidities, or blamed parents for not seeking care. In 2016 my perfectly healthy 2yo woke up with a low-grade fever and died hours later. Flu can kill fast.

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Nick Tschernia, MD retweetledi
NEJM
NEJM@NEJM·
Original Article: Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia nej.md/48wiyQL #ASH25 | @ASH_hematology
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Majzner_Lab
Majzner_Lab@Majzner_Lab·
@drjgauthier Anakinra definitely gets into the CNS. It's recombinant IL1Ra so pretty small (cytokine sized, smaller than IL-6). It's detectable by ELISA/Luminex for IL1Ra. We found it at ~10% of systemic levels in brain tumor pts treated with CAR T. nature.com/articles/s4158…
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Jordan Gauthier
Jordan Gauthier@drjgauthier·
One small clarification for the record, in light of Dr. DiPersio's comment that anakinra does not penetrate into the CNS. While anakinra is a large molecule, measurable CSF penetration and CNS biologic activity have been demonstrated in multiple settings of neuroinflammation when high dose of anakinra are administered, including SAH and autoinflammatory CNS disease. A very good example supporting CNS penetration of anakinra is its high efficacy in Neonatal-Onset Multisystem Inflammatory Disease (NOMID), which typically manifests with leptomeningeal inflammation; Left panel, shows brain MRI before anakinra; right panel, after anakinra treatment. From: nejm.org/doi/full/10.10… #neuroinflammation #anakinra
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Jordan Gauthier@drjgauthier

Dr. @emilyliangmd expertly presenting at #ASH25 the largest study to date diving into the use of anakinra for refractory/severe ICANS (n=101). We benchmark key clinical outcomes, and identify potential predictive biomarkers of anakinra efficacy. Prospective comparative studies critically needed! #CARTx #anakinra #CARTOX @OHSUNews

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Nick Tschernia, MD
Nick Tschernia, MD@NickTscherniaMD·
@Papa_Heme -Marsigliano's on West Sahara -Brooklyn's best (couple locations) -Lucinos pizza on East trop is a decent Philly spot for pizza -Pizza rock is solid for Detroit style -And there's something about the margherita slice at pin up pizza with these blistered salted cherry tomatoes
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Papa Heme
Papa Heme@Papa_Heme·
Ok anyone know the best pizza place in Las Vegas. I need some good pizza
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Nick Tschernia, MD
Nick Tschernia, MD@NickTscherniaMD·
@Dr_RShatsky Agreed, we've seen those w/o insurance get roped into these false hopes. Unfortunately had to take a pt off trial after they started them (despite counseling) and developed acute transaminitis. Now in nearly every consult this comes up now, far more prevalent than 5+yrs ago.
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Rebecca Shatsky, MD
Rebecca Shatsky, MD@Dr_RShatsky·
I have been seeing an epidemic of patients presenting to the hospital in critical condition with Stage IV now incurable cancer because they are listening to people like this and trying to treat their cancer with ivermectin and fenbendazole. They are dying because they missed their chance at cure by doing this. Please don't be this naive. If someone is telling you something that is contradictory to what the entire international oncology community tells you about your cancer it’s not because these charlatans know something miraculous that the rest us of who have dedicated our entire lives to cancer research don't. Remember, if it sounds too good to be true, it likely is. Also please remember there is no single treatment that would treat all cancers, there are hundreds of different types of cancer and they are all different. Why would the same treatment works for all cancer??? It doesn't. Cancer isn’t one disease and there is no treatment that just works for everything.
Joe Tippens@JoeTippen

Bret & Heather Weinstein recommend Ivermectin and fasting over traditional Cancer treatments like Chemo and radiation. #Ivermectin #Fenbendazole #Cancercure

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Nick Tschernia, MD
Nick Tschernia, MD@NickTscherniaMD·
@mcuban Went to a public med school, I was on the student board. The school began raising the med tuition 10-20%/yr. But we knew the numbers, out of the University the med school was in the black. Asked why raise tuition, the answer? A more expensive tuition = a more valuable education
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Ben Derman
Ben Derman@bdermanmd·
Is your center allowing for BCMA CAR T-cell therapy in patients with myeloma on dialysis for renal failure? We describe our early experience with ide-cel/cilta-cel in patients on dialysis. Bottom line: - Don't let ESKD be a barrier! - Reducing fludarabine + dialyzing each day afterward worked well - Note: there may be a signal for increased risk of IEC-HS
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Nick Tschernia, MD
Nick Tschernia, MD@NickTscherniaMD·
@tmprowell Admittedly some selection & availability bias on my part, but the # of anxious pts posting on forums (eg reddit) img reports or raw labs asking for interp has ⏫. More fam/friends asking for curbsides. Ideally we'd prep what to expect in adv & see in clinic qkly, otherwise opt-in
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Tatiana Prowell, MD
Tatiana Prowell, MD@tmprowell·
This is an interesting patient perspective on viewing results in the electronic health record immediately versus waiting to receive results from clinicians. I have seen evolution in a given patient in both directions. What do you think? #OncTwitter #MedTwitter #PatientExperience
Katie Coleman@kaydaustin

Scan results this morning. First time in several years, I’m headed into my appt blind, without having read or looked at my scans. The further out I get from my diagnosis, the more I’m convinced “what do patients want” is a moving target. I used to read my reports the second

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Pashtoon Kasi MD, MS
Pashtoon Kasi MD, MS@pashtoonkasi·
🆕🗞️Hot off the press! @NatureMedicine #KRAS Vaccine💉for patients with RAS➕cancers🎯. Benefit➡️durable.🙌🏽 More to come with the randomized study📚✔️! Opens to doors to off the shelf vaccine for so many patients with KRAS/NRAS mutations. @OncoAlert 🔗nature.com/articles/s4159…
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Waggoner Lab
Waggoner Lab@LabWaggoner·
T cell are critical for anti-tumor immunity reprogramming by radiotherapy, but tumor cell derived protein C receptor-driven IL-6 inhibits this nature.com/articles/s4146… @NatureComms
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Yaneer Bar-Yam
Yaneer Bar-Yam@yaneerbaryam·
Breakthrough study: COVID-19 reactivates dormant breast cancer, triggering deadly metastasis (shown in mice). In humans, cancer survivors who got COVID had 4.5× higher cancer-related deaths—and 1.4× greater breast cancer. nature.com/articles/s4158…
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Al-Ola A Abdallah MD (USMIRC)
Al-Ola A Abdallah MD (USMIRC)@Abdallah81MD·
🚨🚨Phase 2 trial on itacitinib for CRS/ICANS prevention in CAR T-cell therapy Highly recommended to read as this could be applicable for CAR-T in myeloma and BiTes as well 🧵1/ Groundbreaking update in CAR T-cell therapy: Can we prevent CRS and ICANS, rather than just react to them? 💊 New study shows prophylactic itacitinib (JAK1 inhibitor) significantly reduces CRS without compromising CAR T efficacy. #ICE_T #mmsm #MedEd #myeloma #MedTwitter #USMIRC @USMIRCNEWS @OncoAlert #سرطان_الدم #المايلوما
Al-Ola A Abdallah MD (USMIRC) tweet media
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Kai Rejeski
Kai Rejeski@KRejeski·
🚨 New in Nature Medicine: “Noncanonical and mortality-defining toxicities of CAR T cell therapy” As CAR-T moves beyond heme malignancies, we need a deeper understanding of rare & long-term toxicities. 🔗 nature.com/articles/s4159… PDF: rdcu.be/ewqLH
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