Brandon Pratt

Review @J_Immunol @JSRustenhoven @AucklandUni Skull bone marrow immunity in brain health and disease: mechanisms and models academic.oup.com/jimmunol/artic…

🧵Excited to share my thesis work out today in @NeuroCellPress from @kipnislab and @TheColonnaLab: "Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Properties." 🧠🦴 sciencedirect.com/science/articl…

New @ScienceMagazine Engineering the brain's astrocytes to clear amyloid plaque! "CAR-A," in mouse model science.org/doi/10.1126/sc… science.org/doi/10.1126/sc…

🕰️🚆🦠 Excited to share our new preprint: “Optimal transport fate mapping resolves T cell differentiation dynamics across tissues”! We use OT to infer realistic CD8 T cell differentiation and migration trajectories from scRNA-seq timecourses. biorxiv.org/content/10.648… 1/

@biorxivpreprint Optimal transport fate mapping resolves T cell differentiation dynamics across tissues biorxiv.org/content/10.648… @JJMilnerLab @UNC_Lineberger @natstann

New in Nature Neuroscience: we identify a previously unrecognized barrier at the choroid plexus–brain-CSF interface. nature.com/articles/s4159… 🧵👇

A framework for reparative CAR T engineering in the CNS biorxiv.org/content/10.648… #biorxiv_immuno

@biorxivpreprint Harnessing Inflammatory Monocytes to Overcome Resistance to Anti-PD-1 Immunotherapy biorxiv.org/content/10.648… @UNC

Excited to share our new paper out in PNAS today: we developed amyloid-β–targeting CD4 CAR-T cells and demonstrate their ability to alter amyloid pathology and immune dynamics in an Alzheimer’s disease models. pnas.org/doi/10.1073/pn…

More direct evidence from T cells for the Epstein-Barr virus playing a fundamental role in multiple sclerosis @NatImmunol nature.com/articles/s4159…

Atlas-guided discovery of transcription factors for T cell programming @Nature @salkinstitute @Tcellogic @UCSD nature.com/articles/s4158…

Congrats @HKayChung1 on this incredible work!

I am excited to share our latest research out today @NatureGenet; here we discovered childhood brain tumours instruct cranial hematopoiesis and identify a clinically relevant mechanism to re-educate the skull bone marrow. nature.com/articles/s4158…

Precision CRISPR annotation of the functional enhancer landscape in primary human T cells biorxiv.org/content/10.648… #biorxiv_immuno

⚠️ If you’re reading this, you’ve been infected* ⚠️ *~95% the human population has been infected by the Epstein-Barr Virus (EBV). Today in @Nature with @nyeo_sherry, @EMC22381830, @RyanDhindsa @SlavePetrovski, we shed some light on what happens next. nature.com/articles/s4158…

Excited to share our new @NatImmunol paper mapping the immune microenvironment and TCR repertoire in the border of the human degenerating brain using scRNA/TCR-seq and spatial proteomics @RyanMHobson @bradshaw2280 nature.com/articles/s4159…

CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer biorxiv.org/content/10.648… #biorxiv_immuno

Thrilled to share our first iteration of IL-12–armored CAR T cells targeting tumor associated macrophages (TAM) to treat metastatic cancer. Led by the fantastic @jaimemateustique as a collaboration between @brown_lab1 and my lab @sinaiimmunology. authors.elsevier.com/a/1mUUD5TA51lD… (1/4)

@biorxivpreprint Latent Regulatory Programs Generate Synthetic T Cell States with Enhanced Therapeutic Potential @JJMilnerLab @Pratt__Brandon @UNC_Lineberger biorxiv.org/content/10.648…

One-step generation of TCR knock-in mice targeted to the TCRβ locus results in functional mature T lymphocytes biorxiv.org/content/10.648… #biorxiv_immuno