S.Zhang Lab

Spring is finally here! 🌱 Looking forward to a new season of fresh ideas, focused writing, and productive days ahead in the lab. Let's make it count. 🔬✨

I am totally impressed by analemma.ai/fars the best part of this that AI researcher is honest and hardworking 😂

We mapped gene interactions across different environmental conditions (GxGxE) at scale for the first time in human cells. These maps lead to the realization that many genes function in a context dependent manner which provides insight into how humans have relatively few genes but many cell types. Congratulations Ben! Paper: cell.com/molecular-cell…

An imaging-free spatial transcriptomics method facilitates high-throughput barcode array generation up to centimeter scale go.nature.com/3QYfSDd rdcu.be/e4Db0

Revealing a coherent cell-state landscape across single-cell datasets with CONCORD go.nature.com/4jsNxSL

Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment go.nature.com/4qFvMlG

Pooled genetic CRISPR screening is improved in complex models through leveraging internal controls go.nature.com/4giANvD rdcu.be/eRy4P

Gene context drift identifies drug targets to mitigate cancer treatment resistance dlvr.it/TMyBWv

The creative process in science has its thinking tools, which we all learn eventually. Here are the 12 articles that Martin and I wrote about them, including "It takes two to think" and "A hypothesis is a liability". night-science.org/home/learn/rea… @nightsciencepod @MartinJLercher

Excited to share our review on metabolic adaptations in brain metastasis in @NatureRevCancer!! 👉rdcu.be/exHzY A pleasure to co-write with Pravat @CMTLab_IISERBPR and appreciate the support Daniela @DaniS2911 @utswcancer @UTSWCancerBio @UTSW_Pathology @UTSWMedCenter

A generative artificial-intelligence tool has designed a synthetic CRISPR system that successfully edits human DNA go.nature.com/3JadkRy

📢 Introducing Biomni - the first general-purpose biomedical AI agent. Biomni is built on the first unified environment for biomedical agent with 150 tools, 59 databases, and 106 software packages and a generalist agent design with retrieval, planning, and code as action. This enables Biomni to perform a wide range of research tasks - from literature review, hypothesis generation, protocol design, data analysis, clinical reasoning, and much more - across subfields like genomics, microbiome, physiology, and beyond. Some key results: 🔬 Designed a molecular cloning experiment validated in wet lab, matching the performance of a >5-year expert in a blinded test 📊 Completed a wearable bioinformatics analysis across 458 messy files in 35 min vs. 3 weeks by a human 🧠 Uncovered novel transcription factor hypotheses driving skeletal lineage regulation We built a web platform where biomedical scientists can immediately delegate their tasks to the agent today, completely free! 🧪 Try it now: biomni.stanford.edu 📄 Paper: biomni.stanford.edu/paper.pdf 💻 Code: github.com/snap-stanford/… (will be fully open-sourced very soon!) 💬Join the community: tinyurl.com/biomni-slack Biomni is an open-source initiative: we invite the community to build on it and advance biomedical research at scale. With amazing collaborators @StanfordAILab @StanfordMed @StanfordCancer @genentech @arcinstitute @UCSF @UW @PrincetonAInews @serena2z @hcwww_ @YuanhaoQ @mintaylu @yusufroohani @RyanLi0802 @LinQiu0128 Gavin Junze Di Shruti Jennefer Xin Zhou @MWheelerMD Jon Bernstein @MengdiWang10 @PengHeAtlas @SnyderShot @lecong Aviv Regev @jure

Congrats to our recent Pathology @UTSWGradSchool students for receiving their PhDs! 🎓 Dr. Ryan Kowash – Cancer Bio (Mentor: Esra Akbay) Dr. Samantha Golomb – Cancer Bio (Mentor: Siyuan Zhang) Dr. David Sanchez – Genetics, Development & Disease (Mentor: Diego Castrillon)

Why I teach my students about scientific failure | Science | AAAS science.org/content/articl…

Thank you Elina and Dmitry for highlighting our study and its impact on advancing our knowledge of TAM regulation and myeloid therapeutics. cell.com/cancer-cell/fu…

The Department of Pathology at UT Southwestern (@UTSWMedCenter) is looking to recruit exceptional tenure-track/tenured basic science and translational investigators at all career levels! Please spread the word and see link below for more information. jobs.sciencecareers.org/job/670469/ten…

Worked on this for a long time and happy to publish what is hopefully just the beginning stages of an interesting sub-field of brain metastasis research! Thank you to @SZhang_Lab, co-authors and labmates🤓🍀🤠 @NDBios @UTSWCancerBio tinyurl.com/yh6wb9wt

Temporal dynamics of immune cell transcriptomics in brain metastasis progression influenced by gut microbiome dysbiosis @CellReports @sam_golomb cell.com/cell-reports/f…

@LabWaggoner @CellReports @sam_golomb Thank you for tweeting our study :D