Sudha Mishra

Delighted to share this amazing collaborative study involving our laboratory @IITKanpur now published in @Nature! This was spearheaded by David Baker's lab @UWproteindesign with contributions from several labs across the globe! Link: nature.com/articles/s4158…

The dream of every cell is to become two cells.” François Jacob This is what cell division of algae looks like, this is a Micrasterias rotata algae cell dividing

Chemistry writes the story of life. Every cell, every second, it tells it again - powered by molecular design. At the core of this process lies the citric acid cycle, the central hub of metabolism. Here, acetyl-CoA derived from carbohydrates, fats, or proteins enters a precise series of reactions that convert fuel into energy. Each step transfers electrons, drives ATP synthesis, and sustains the continuous renewal of life at the cellular level. What may seem invisible is, in fact, the most constant motion in existence; the quiet rhythm of biochemistry that powers everything we do.

Thrilled to share our new study on CXCR7/ACKR3! Using cryo-EM, we reveal a unique activation mechanism for CXCR7/ACKR3, including how it serves as an atypical opioid receptor. Read the full open-access article here: biorxiv.org/content/10.110…

Excited 🎉to share our new study that dives deep into CXCR7/ACKR3, showing atypical activation mechanism of this receptor and its role as an atypical opiod receptor. Read the article here 👇🏻

Molecular mechanism of naturally-encoded signaling-bias at the complement anaphylatoxin receptors biorxiv.org/content/10.110… #biorxiv_biochem

Excited to share our new preprint online. We uncover how an intrinsically biased chemokine receptor undergoes atypical activation through a molecular glue–like dimerization mechanism. biorxiv.org/content/10.110…

Thrilled to share my first PhD paper on intrinsically biased receptor CXCR7 is now live on bioRxiv🎉 This milestone would not have been possible without the constant guidance and encouragement of my mentor @arshukla. Grateful for constant support ✨ biorxiv.org/content/10.110…

Delighted to share our comprehensive study elucidating the intrinsic-bias encoded in the complement anaphylatoxin receptor system 😎!!! Molecular mechanism of naturally-encoded signaling-bias at the complement anaphylatoxin receptors biorxiv.org/content/10.110…

How do complement anaphylatoxin receptors encode signaling bias? Our new bioRxiv preprint deciphers the molecular mechanism underlying naturally biased signaling at these complement GPCRs. biorxiv.org/content/10.110…

Delighted to share our latest study on atypical activation and dimerization of an intrinsically-biased chemokine receptor, CXCR7! Atypical activation and molecular glue-like dimerization mechanism of an intrinsically-biased chemokine receptor biorxiv.org/content/10.110…

✅✅ A reminder by Dr. Rahaf Ajaj: She wasn’t on the Stanford list… but she made it to the Nobel stage. 🏅 Mary E. Brunkow, one of this year’s Nobel Prize winners in Medicine, has only 34 published papers and an H-index of 21. She never appeared in Stanford’s ranking of the world’s top 2% of scientists. She didn’t chase citations, metrics, or the spotlight. Yet, she became part of a discovery that changed how humanity understands the immune system. Today, while many are busy chasing numbers, titles, and rankings — she reminds us what truly matters in science: the question. 🔹 She wasn’t running after the lists. 🔹 She was running after the truth. Because in the end, it’s not about how many papers you publish… It’s about how deeply your idea can reshape the world. Focus on your idea, not your ranking.

🚀 New from our lab! A genetically encoded nanobody sensor (Ib32) reveals that different GPCRs sculpt β-arrestin into distinct conformations, offering receptor-specific fingerprints of signaling. pnas.org/doi/10.1073/pn…

It was such an incredible learning experience with this phenomenal team @ParishmitaSarm2 @SudhsM7 @NashrahZaidi 🙌 And to my guide- the incredible, truly inspiring, one and only @arshukla 🌟 forever grateful for your mentorship & support! 🚀✨

@IITKanpur @LazarLab @IOCBPrague Many thanks to @IndiaDST for supporting this work through a joint Indo-Czech project! We are also immensely thankful to @India_Alliance @ANRFIndia @DBTIndia @ICMRDELHI @EMBO_YIP @CSIR_IND for supporting the research program in our laboratory over the years!

Many congratulations to all involved including amazing students and fellows from our laboratory @IITKanpur and from the laboratory of our collaborator @LazarLab @IOCBPrague !

Delighted to share our latest study on a nanobody-based sensor of GPCR activation and signaling! A genetically encoded nanobody sensor reveals conformational diversity in β-arrestins orchestrated by distinct seven transmembrane receptors | PNAS pnas.org/doi/10.1073/pn…

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard

Potato evolved from tomato 9 million years ago. cell.com/cell/fulltext/… @NHM_London Sandra Knapp @UBC Loren H. Rieseberg @SCUCN Jianquan Liu #CAAS Sanwen Huang @cellcellpress

7/n In order to understand the fascinating pharmacology and biology of these incredibly versatile receptors, we reconstituted a broad set of agonist-receptor-G-protein ternary complexes in various combinations, and determined a total of seventeen cryo-EM structures😎.