Jason Spence

Mapping mesenchymal diversity in the human small intestine and organoids @NatureCellBio @TheSpenceLab @UMich nature.com/articles/s4155…

We have hundreds of PanINs in our pancreas, especially after age 40. They are a pre-cancerous lesion, but it is fortunately rare for one to progress to cancer (PDAC). Now we know a reason for that. The microenvironment. @umichmedicine @UMRogelCancer aacrjournals.org/cancerdiscover… @CD_AACR

Our paper is out in @ScienceMagazine Here we describe how stem cell retain epigenetic inflammatory memory long-term. Full text in the link below! Congratulations @chris_cowley14 @SairajSajjath @LFSoto12 and everyone else involved! science.org/doi/10.1126/sc…

It’s well known that inflammation increases cancer risk, but how? The answer: the epigenome "remembers" inflammation and primes stem cells for cancer. Here is our paper: nature.com/articles/s4158… And a special shoutout to the lead author @snaga13 A 🧵

@TanentzapfLab @TanentzapfLab - I was inspired by this post, and just sent my first email reply (of many?) saying that the document looked good and feel free to sign on my behalf!

For academics how much time is spent & how many emails are sent just to get documents signed? If we eliminated tomorrow the need for signatures on everything what will be the -ve consequences? I strongly believe time saved & reduced cognitive load outweighs these consequences.

Villi and its microvilli

🚨Don't forget to secure your place at our new conference! 3rd Stem Cell - Niche Interactions in the Gastrointestinal Tract 📆 Date: 10 Jul - 13 Jul 2026 📍 Location: Lisbon, Portugal 📢Early Bird & Talk Submission: 07th May 2026 Don't miss out, Register now: bit.ly/4k4B7Rr #FusionDevBio #FusionStemCells

@ChanZuckerberg We identified two transcriptional states for alveolar AT2 cells. Using spatial transcriptomics, we found that AT2 cell states reside in specific niches (neighborhoods), interact with distinct alveolar fibroblast subtypes and are driven by inflammatory/anit-inflammatory signals.

Excited to share our newest preprint, "Clinical Interventions and Inflammatory Signaling Shape the Transcriptional and Cellular Architecture of the Early Postnatal Lung". Led by Tristan Frum with funding from the @ChanZuckerberg Pediatric Network. biorxiv.org/content/10.110…

@biorxivpreprint Clinical Interventions and Inflammatory Signaling Shape the Transcriptional and Cellular Architecture of the Early Postnatal Lung biorxiv.org/content/10.110… @TheSpenceLab @UMichMedSchool

New #organoid preprint from the Spence Lab, the Translational Tissue Modeling Laboratory (UmichTTML.org) in collab with @jonnysexton @SextonLabUM A scalable long-term in vitro model of human colonic epithelium with continuous barrier function biorxiv.org/content/10.110…

Human-mouse cross-species comparison identifies common and unique aspects of intestinal mesenchyme development biorxiv.org/content/10.110… A companion piece to our recent work from my colleague Kate Walton, led by Kelli Johnson and Xiangning Dong!

@KrishnaswamyLab @Yale @YaleEngineering @YaleMed @YaleGenetics @YALECS Congrats Smita!

Today marks my 10th year anniversary of joining @Yale @YaleEngineering @YaleMed @YaleGenetics @YALECS ... its been an amazing ride that only keeps getting more exciting! (me ten years ago below)!

Impaired stromal-epithelial cross-talk in Hirschsprung disease highlights the risk of epithelial damage, suggesting a therapeutic option science.org/doi/10.1126/sc… @ScienceTM

Excited to share our latest preprint led by Kelli Johnson- Mapping mesenchymal diversity in the developing human intestine and organoids! We defined 5 mesenchymal populations occupying discrete anatomical locations within the human intestine. biorxiv.org/content/10.110…

🔬Advances in Precision Medicine underscore the importance of 🧬biomarker-informed care in NSCLC. Learn how upfront NGS testing can provide the most comprehensive biomarker information, while also reducing overall cost and time to results: e.lilly/3FiWnDe

Diet/microbes place the gut epithelium as a nexus for evolutionary change. With @TheSpenceLab @genomeCraig, we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @ScienceMagazine #evodevo 🧵1/11 science.org/doi/10.1126/sc…

Recent evolution of the developing human intestine affects metabolic and barrier functions @ScienceMagazine @GrayCampLab @TheSpenceLab science.org/doi/10.1126/sc…

We are very excited to officially launch our single cell proteomics service!! Please, check out our website if you want to work with us! sidolilab.org/single-cell

So honored to receive a BWF CAMS and thankful to all of my mentors and supporters along the way! BWF Announces 2025 Career Awards for Medical Scientists bwfund.org/news/bwf-annou…