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Thrilled to share our paper now out @NatureBiotech! High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails
nature.com/articles/s4158…
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Vivasvan Vykunta
27 posts
Vivasvan Vykunta
@VivaVykunta
MD-PhD Student @UCSF_MSTP with @MaxKrummel | Previously @MarsonLab @GladstoneInst and Zikherman Lab @UCSF | @PDSoros Fellow '26 | Immuno-engineering and biking
California Katılım Eylül 2021
126 Takip Edilen96 Takipçiler
Vivasvan Vykunta retweetledi
Nature research paper: Submicrometre sampling of living cells by macrophages
go.nature.com/4cZs2Gv
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Vivasvan Vykunta retweetledi
Excited to announce our study (w/ @RukmanThota & @MaxKrummel) published today @Nature:
Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells.
nature.com/articles/s4158…
#immunology #cellbiology @immunox @ucsf
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I'm honored to be among this year's @PDSoros Fellows! Check out the new cohort and all they've accomplished: pdsoros.org/meet-the-class…
Immensely grateful to @MaxKrummel, Alex Marson, @brshy, Julie Zikherman and many many more mentors who took a chance on me early in my training!
PD Soros Fellowships@PDSoros
Today, we announced the 2026 Fellows—we hope you will read their incredible stories and learn about their work! Selected from 3,000+ applications, it was the most competitive year in our history. pdsoros.org/meet-the-class…
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Vivasvan Vykunta retweetledi
Excited to present the first major work after starting our lab at Stanford and the Arc this year: CRISPR-All, a unified genetic perturbation language for programming any major type of genetic perturbation simultaneously, in any combination, at genome scale, in human cells.
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Vivasvan Vykunta retweetledi
🚨Excited to share our latest work, now out in @NatureBiotech ! We introduce SEED-Selection, a powerful method that enables high-efficiency enrichment of T cells edited at multiple loci in a single step 🧵👇
🔗 nature.com/articles/s4158…
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Vivasvan Vykunta retweetledi
SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci go.nature.com/4gBnaqY
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Excited to share this new piece!
From taking art classes together back in grade school and visiting colleges together in high school to now being co-first authors, I'm looking forward to continue working and learning with @rishabrama in our future training and careers!
Rishab Ramapriyan, MD@rishabrama
Excited to share our new review on altered cancer metabolism and implications for next-generation CAR T-cell therapies-- written with @VivaVykunta @GustVandeca @LGKRichardson @WTCNeuroscience @BryanDChoi @MGHNeurosurg Full Paper: authors.elsevier.com/a/1j8rTbEXZb8Dd
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Vivasvan Vykunta retweetledi
New research in mice indicates that #MastCells secrete an essential metabolite in Peyer’s patches needed for the production of for intestinal #immunoglobulin A. scim.ag/65C #IgA @MarcoDegiov89 @UCSF
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Vivasvan Vykunta retweetledi
Intestinal IgA production depends on GPR35-expressing cDC2 positioning guided by mast cells within Peyer’s patches @MarcoDegiov89 @jason_cyster @SciImmunology
science.org/doi/10.1126/sc…
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First paper from my time in @UCSF_MSTP is out today @SciImmunology! Had a blast learning from and working with @MarcoDegiov89 and the whole Cyster Lab @UCSF -- looking forward to seeing how the De Giovanni Lab continues this work!
De Giovanni Lab@MarcoDegiov89
Excited to share our latest results published in @SciImmunology unravelling how mast cells control dendritic cell positioning to sustain intestinal IgA production #Cysterlab @ArmeniseHarvard @SanRaffaeleMI @UCSF science.org/doi/10.1126/sc…
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Vivasvan Vykunta retweetledi
🚨 New study for the lab!
We developed SEED selection, a method to purify KnockIns at multiple loci in a single step. Better, It takes no space in the donor template, can be easily multiplexed and its all through negative selection!
👏👏 @ChrisRChang
biorxiv.org/content/10.110…
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Vivasvan Vykunta retweetledi
Ultra-high efficiency T cell reprogramming at multiple loci with SEED-Selection
ift.tt/cMkL5pG
#biorxiv_synbio
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Sister’s doing a lot of big science on the other side of campus! 👏🏽
RaleighLab@LabRaleigh
Akshara (proudly too cool for Twitter/X/whatever) presenting her honors thesis research from @LabRaleigh at @UCBerkeley. Look for her graduate school application in 2024, folks! @UCSFGradDiv @UCSFCancer @UCSF @NeurosurgUCSF
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Vivasvan Vykunta retweetledi
Zikherman and colleagues describe a new mechanism by which B cells recognize virus-like antigen display as a stand-alone danger signal that does not rely exclusively on avidity and BCR cross-linking. Read it here: rdcu.be/dlGBQ
#Abs1" target="_blank" rel="nofollow noopener">nature.com/articles/s4159…
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Vivasvan Vykunta retweetledi
I am so glad someone finally published on the mechanism by which high valency antigens induce better B cell responses than soluble ones
rdcu.be/dlvFO
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Great to see this published and thankful to have played a small part in this story during my time with @MarsonLab! Enjoyed working with my previous roommate, Dan, to develop ideas together -- Excited to see how this new tech impacts the genome engineering space!!
Ross Wilson@RossWilsonLab
I’m excited to share our report - out now in @natBME - of a new approach to CRISPR delivery that is poised to transform the way engineered T cell therapies are manufactured. Visit tinyurl.com/CRISPR-PERC for “how to” details. It’s threadin’ time! (1/11) nature.com/articles/s4155…
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Vivasvan Vykunta retweetledi
Molecular basis for potent B cell responses to antigen displayed on particles of viral size biorxiv.org/cgi/content/sh… #biorxiv_immuno
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Vivasvan Vykunta retweetledi
Authored by Andrew G. Soerens et al, we show that #Tcells are capable of proliferating in response to iterative stimulation for over 10yrs! And produce enough progeny to occupy a volume 30,000x the Earth's volume! @Nature nature.com/articles/s4158…
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Vivasvan Vykunta retweetledi
Combinations of single-stranded DNA repair templates and small molecules markedly enhance genome editing go.nature.com/3dS9NYC
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Vivasvan Vykunta retweetledi
I am very grateful for this fantastic paper and this incredible opportunity to collaborate with so many amazing authors. One more step for #CARTcells #mmsm and patients! Thanks @MarsonLab @brshy
@VivaVykunta @j_eyquem @TomBmt133 @UCSFMedicine @GladstoneInst
Tweetorial here: 👇
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