Walid Khaled

I am pleased to share the final version of our Human Breast Cell Atlas with @MarioniLab now out @NatureGenet. There are important new additions, which I will leave to @Dr_SaraPensa and @AustinDReed to mention👇 . Couple of points i want to highlight 👇: nature.com/articles/s4158…

In 1999, Tom Maniatis discovered something remarkable: neurons achieve self-avoidance via stochastic methylation of the protocadherin gene cluster. We've just discovered this locus is an evolvable in-vivo barcode across the human tissues: biorxiv.org/cgi/content/sh… 🧵

Thrilled to share the latest paper from our lab @MunozEspin_Lab @EarlyCancerCam, done in close collaboration with Prof James Brenton’s and Prof Masashi Narita’s laboratories @Narita_lab @CRUK_CI, and published in @NatureAging nature.com/articles/s4358…

Fantastic opportunity to share our work at @SCICambridge. Thanks @WTKLAB for the invitation to disccuss science and enjoy beautiful Cambridge sunshine and immersive College dinner.

Ladies and gentlemen - Our Atlas of Human Inflammation today out in @NatureMedicine 💫 Welcome on stage: The Cell as a Living Biomarker🩸 We Built an Inflammation Atlas of Circulating Immune Cells. By profiling more than 6.5 million peripheral blood mononuclear cells from 1,047 patients across 19 inflammatory and immune-mediated diseases using single-cell RNA sequencing, we generated a unified, high-resolution reference of immune cell states in human disease. Despite decades of research, our understanding of Inflammation has largely remained fragmented, studied one disease at a time and often confined to specific tissues. We set out to take a different approach: to ask whether inflammation leaves a shared, measurable fingerprint at the systems level of circulating immune cells and whether this signal could be leveraged for Diagnostics and ultimately Precision Medicine. Blood, unlike tissue biopsies, is accessible, repeatable, and scalable, making it an ideal substrate for liquid biopsy approaches. The key question was whether it also contains sufficient biological signal to capture disease-driving inflammatory mechanisms❓ Using interpretable machine learning approaches, specifically gradient boosted decision trees (GBDT) combined with SHAP explanations, we asked whether single cells, and ultimately patients, could be classified based solely on their blood immune transcriptomes. !!! Disease-associated gene expression signatures enabled accurate classification within the study cohort, reinforcing the concept that immune cells in circulation function as “Living Biomarkers”🩸 We are now working toward a diagnostic prototype that brings these concepts closer to clinical reality. Together with hospital and industry partners, we aim to develop Foundation Models of immune cell plasticity that can operate across diseases and settings, enabling patient stratification, therapy monitoring, and outcome prediction from blood alone. Our long-term vision is a future in which a simple blood draw provides a systems-level readout of immune health, guiding diagnosis and treatment across inflammatory diseases. Immune cells are already doing the sensing. The challenge and opportunity is to learn how to listen. Please find the Nature Medicine Paper here: lnkd.in/eYV7pwrN

@MahataBidesh @JustGiving I’m very sorry to hear about this Bidesh.

I lost my son this year. On his 21st birthday, I made an oath: Fulfil his last wish. I'm raising funds for Mental Health Research UK in his memory. Please read his story, share, talk about mental health & donate if you can. 💙 @JustGiving Thank you! justgiving.com/page/samay-mah…

Thrilled our study on anti-progestin therapy for breast cancer prevention is out! A pleasure to be part of the team led by Bruno Simões, @RobClarkeLab + @DrSachaHowell, @MCRBreastCentre w @rmkhokha @WTKLAB. Team science moving us towards cancer prevention! nature.com/articles/s4158…

PAPER OUT!! 🥳🥳🥳 Clinical potential of WGS data linked to mortality statistics in patients with breast cancer in England #shout out to #DaniellaBlack ⁦@GenomicsEngland⁩ ⁦ And all the patients that shared samples across @NHS 1/n sciencedirect.com/science/articl…

Could PARP inhibitors, targeted drugs already used to treat cancer, also help prevent it? We're part of a coalition of charities that believes the answer could be yes. And we're calling for urgent research to find out. breastcancernow.org/about-us/media…

Excited to share our new preprint introducing CenSegNet, a deep learning framework for high-throughput, spatially resolved, single-cell centrosome profiling in heterogeneous tissues. Co-led by brilliant PhD students, Jiaoqi Cheng & Keqiang Fan. 1/3 biorxiv.org/content/10.110…

@LabKissil @Dan_Lester8 @aventura71 @psalmotoxin @ShelleyBuffens1 @KYTsaiLab @LabElsaFlores @CD_AACR Congrats Joe on team on this very important paper!

Congratulations to the team on all their hard work on developing this first of its kind model! @Dan_Lester8 @aventura71 @psalmotoxin @WTKLAB @ShelleyBuffens1 @KYTsaiLab @LabElsaFlores @CD_AACR

Thrilled that our paper is finally in press @ScienceMagazine!! *Platelets sequester cell free DNA, including free fetal and tumour-derived DNA* Tweetorial from @l_cmurphy below. Check out the news feature science.org/content/articl… and terrific editorial from Dennis Lo

We are recruiting….Any clinician interested in doing a PhD in London on lymphoma and mechanisms of transformation/ TME….please apply (and get in touch with us)

(1/12) Over a year ago, we launched a new project to explore whether the tissue microenvironment could predict cellular behaviour and whether reprogramming might unlock new therapeutic avenues. 🧬 Spatial transcriptomics provides deep insights into tissue organisation. We wanted to take this further by building a model that predicts how the tissue microenvironment rewires cells, and in silico predict how reprogramming influences the diseased microenvironment. Today, in collaboration with @Muzz_Haniffa at @sangerinstitute we’re excited to share the preprint for Mintflow, including two novel disease datasets. Link to preprint: shorturl.at/alFUO 🧵

Today saw our final year PhD students and MPhil students give talks on their research, whilst 2nd years presented posters of their progress so far 😀 A great day showing the diversity of research in the Department - congratulations to poster and talk prize winners!

We’re thrilled to share our latest publication in @Cancer_Cell, and very proud of C. Rozalén for this tour de force uncovering how TIM3⁺ breast cancer cells drive immune evasion during micrometastasis. #CancerImmunology #BreastCancer #Metastasis cell.com/cancer-cell/fu…

@RahmanLab 👏👏👏

welcoming rain!

Not long left to apply! Join us at the Stem cells and Cancer conference in Malta. Deadline 31st July!

Could this be the future of cancer prevention? Walid Khaled @Cambridge_Uni, a new ERC Advanced Grant recipient, will work on a preventive vaccine for breast cancer. 👉 europa.eu/!WPxYgx #ERCAdG #CancerResearch #FrontierResearch

@DrWilliamHill @CharlesSwanton @CRUK_MI Congrats Will!

Thrilled to announce I'm moving to the @CRUK_MI to lead the Cancer Origins group! If you're interested in how mutations and exposures drive tumourigenesis—come join the adventure. cruk.manchester.ac.uk/careers/