Wes

Want to visualise multivariable MR analyses using GWAS summary data and identify outlier SNPs in MVMR? Our new preprint introducing radial MVMR is now available, and with accompanying software for R. doi.org/10.1101/2023.0… github.com/WSpiller/RMVMR @ECSanderson @jack_bowdenjack

Our new paper on weak instruments in multivariable MR is now available online! This is joint work with @WesSpiller and @jack_bowdenjack. Short thread below... onlinelibrary.wiley.com/doi/full/10.10…

Our new preprint outlining how gene-by-covariate interactions can be used to evaluate instrument validity is now available online! Thanks to Fernando, Eleanor, George and Jack for great comments and contributions 😀 medrxiv.org/content/10.110…

Assessing the causal impact of adiposity variation on rates of hospital admission: Application of Mendelian randomization medrxiv.org/cgi/content/sh… #medRxiv

@emgm2020 @HamshereMarian @jack_bowdenjack @ECSanderson @iTomRichardson @Nin0nM Youtube tutorials are already online covering summary MR and related software, so if you missed registration and can't wait to get started you can check them out at tinyurl.com/EMGMYT 😁

@HamshereMarian @jack_bowdenjack @ECSanderson @iTomRichardson @Nin0nM @WesSpiller We'd love to have everyone with us but unfortunately we've reached the capacity all around 😔 however, we're recording the workshop, as well as the other sessions and will be sharing with the permission of our speakers!

Mendelian Randomisation Workshop to start in 30 minutes! Joining us are @jack_bowdenjack @ECSanderson @iTomRichardson @Nin0nM @WesSpiller to teach us about pleiotropy robust MR, multivariate-MR, applications to molecular traits and we can hardly wait 💻🤩!

Just such terrible news. Harvey was brilliant, modest, committed to equality in every domain of life, and great company. He leaves whilst still at the height of his powers, with open projects that will continue, and inspiring others. The world is diminished by his passing.

Our Wellcome Trust 4-year PhD in Molecular, Genetic and Lifecourse Epidemiology is now live! findaphd.com/phds/program/m…

Findings from MR suggest alcohol consumption is causally associated with risk of hyperuricemia in Korean men. Great working with @mrc_ieu and @yonsei_u on this project! doi.org/10.1111/1756-1…

Our paper that uses Mendelian randomization to assess whether antihypertensive drugs can be repurposed for the prevention of Alzheimer's disease is now online @IJEeditorial @ProfPatKehoe @richard36418277 @nm_davies doi.org/10.1093/ije/dy…

#mrconf19 highly relevant paper (IMHO) just published on the assumptions required by 2SMR "Two-Sample Instrumental Variable Analyses Using Heterogeneous Samples" @DeborahLawlor2 #STROBE_MR dx.doi.org/10.1214/18-STS…

@mrcieu #mendelianrandomisation conference update. All entries featuring in Friday's MR data challenge session have been made available at tinyurl.com/mrdatachallenge. Thanks to @WesSpiller Come and see @mvholmes @VerenaZuber @QingyuanZhao @ECSanderson and many more in action!

A great day @karolinskainst preaching the MR gospel, we smashed it @WesSpiller! Thanks @Elistif for the invite!

Please circulate widely among your research groups and peers if planning to attend the conference, and encourage them to take part! We look forward to seeing you in Bristol in the summer! Further information on the MR conference is available at mendelianrandomization.org.uk.

Dear Epi-Twitter The MR Data Challenge is an opportunity to explore and develop innovative approaches to causal inference using a rich source of genetic association data taken from Kettunen et al europepmc.org/articles/PMC48…

Ever wondered what Multivariable Mendelian Randomisation actually is? Our new paper explains it all in detail. academic.oup.com/ije/advance-ar…

Use of “no relevance point” in Mendelian randomization as a bias check used for many years journals.plos.org/plosmedicine/a…, and in effect estimation nature.com/articles/srep1… Now @WesSpiller and @jack_bowdenjack formalize this approach and explore the assumptions academic.oup.com/ije/advance-ar…

Come by poster 3373T today to discuss variable selection in Mendelian randomization for correlated risk factors with shared genetic predictors, or anything else Mendelian randomization related! Look forward to productive discussions! #ASHG18

Superpower: the ability to *think* like an economist, yet *not write as one*. The concepts are so useful, just don't use the jargon.

Most talks so far use either UKBB or publicly available summarized data. This enables powerful analyses without requiring genetic epidemiologists to interact with data generators. However, have we gone too far in separating ourselves from medical colleagues? #IGES18