Saloni Sharma

We study the cooperation between Molecular Machines. Work by Vita Vidmar and @borde_celine in collaboration with @OlivierEspeli and @valeroche looking at the interplay of #Transcription and DNA topology is out: nature.com/articles/s4159… 1/7

Very excited to share our recent study on the chemokine receptors, highlighting the dual-agonism in CXCR3-CXCR7 system. Many congratulations to all involved! @arshukla @saha_shirsha ✨✨ nature.com/articles/s4146…

Delighted to share our latest study on chemokine receptors, now published in @NatureComms !!! Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system | Nature Communications nature.com/articles/s4146…

Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2 dlvr.it/TJP3VS

Very excited to share our latest work on the molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2: Molecular Cell!!! cell.com/molecular-cell…

Very excited to share our recent study on the promiscuous ligand binding at the chemokine receptor, CXCR2! @arshukla @saha_shirsha Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2. cell.com/molecular-cell…

Delighted to share our study on promiscuous chemokine binding at a chemokine receptor, now published in @MolecularCell!!! Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2: Molecular Cell cell.com/molecular-cell…

Delighted to share our latest work on a unique 7TMR out in Cell now!! Read more to find out about the functional divergence encoded within the 7TM fold! Enlightening the DARC! cell.com/cell/fulltext/…

Excited to share a recent study from our lab highlighting the structure of enigmatic human Duffy antigen receptor (DARC). Many congratulations to @saha_shirsha @the_rarejm and our amazing mentor @arshukla for his constant support and motivation. cell.com/cell/fulltext/…

Delighted to share our study on structure and function of a unique 7TMR, now published in Cell @CellCellPress! Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor: Cell cell.com/cell/fulltext/…

Very delighted to share our recent paper in cell!! many many congratulations to @saha_shirsha and our amazing mentor @arshukla cell.com/cell/fulltext/…

Glad to share our recently published article, which focuses on the structure and signaling-bias of the niacin receptor. A big shout-out to our mentor @arshukla for his unwavering support and guidance in molding the story into its final shape. nature.com/articles/s4146…

Delighted to share our study on niacin receptor structure & signaling-bias published in @NatureComms !! Spearheaded by our amazing team including @manish31247914, @ParishmitaSarm2, @RamanujBanerje5 and several other members in our laboratory @IITKanpur !! nature.com/articles/s4146…

Delighted to share our study on probing the conformational diversity in GPCR-beta-arrestin complexes !!! A genetically-encoded nanobody sensor reveals conformational diversity in beta-arrestins orchestrated by distinct seven transmembrane receptors biorxiv.org/content/10.110…

Congratulations to all the authors involved! @ParishmitaSarm2 @SudhaMi10975835 @NashrahZaidi @ANNUDALAL7 @GargiM09 @manish31247914 @arshukla

Excited to share a recent study from our lab about a genetically-encoded nanobody sensor Ib32 which can detect GPCR-encoded different beta-arrestin conformations. biorxiv.org/content/10.110…

@arshukla @saha_shirsha Thanks a lot Sir! 😇

What an incredible feeling as a mentor to witness that when the senior student spearheading a project is about to graduate, another student seamlessly eases into the leadership role on the project. So proud of you @saha_shirsha and @_SaloniSharma_ ! #Amazing#Students#Proud#Mentor

A special note of thanks to @saha_shirsha for her constant support throughout the experiments and making everything more fun and easy to understand! Looking forward to more of this companionship! 🥂

Congratulations to all involved @saha_shirsha @gangulymoni @Sayantanxahas @NashrahZaidi @SudhaMi10975835 @ANNUDALAL7 @SamanwitaMohap1 @manish31247914 @RamanujBanerje5 and thanks to our amazing mentor @arshukla for supporting us throughout!

Excited to share our recent work highlighting the selectivity & promiscuity of two C-X-C type chemokine receptors, CXCR2 & CXCR3! biorxiv.org/content/10.110…

@shihoya1 @LIH_Luxembourg @VU_Science @IITKanpur @saha_shirsha @_salonisharma @gangulymoni @Sayantanxahas @NashrahZaidi @ANNUDALAL7 @SudhaMi10975835 @SamanwitaMohap1 @manish31247914 @RamanujBanerje5 @SudarRajagopal This work would not have been possible without the funding and infrastructure support from @India_Alliance @IndiaDST @DBTIndia @serbonline and @IITKanpur !!! Thank you!!! #Fund#Basic#Science #Team#Science

@shihoya1 @LIH_Luxembourg @VU_Science @IITKanpur @saha_shirsha @_salonisharma @gangulymoni @Sayantanxahas @NashrahZaidi @ANNUDALAL7 @SudhaMi10975835 @SamanwitaMohap1 @manish31247914 @RamanujBanerje5 @SudarRajagopal So, in summary, our study provides molecular insights into ligand promiscuity and signaling bias at CXCRs, and also demonstrates a proof-of-principle that naturally-encoded structural mimicry can be recapitulated using synthetic pharmacophores.